Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Yuki Hitomi"'
Autor:
Yuki Hitomi, Yoshihiro Aiba, Kazuko Ueno, Nao Nishida, Yosuke Kawai, Minae Kawashima, Makoto Tsuiji, Chisato Iwabuchi, Sanami Takada, Noriko Miyake, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-12 (2022)
Abstract Background Ligation of CD28 with ligands such as CD80 or CD86 provides a critical second signal alongside antigen presentation by class II major histocompatibility complex expressed on antigen-presenting cells through the T cell antigen rece
Externí odkaz:
https://doaj.org/article/42bb9750cc5441d69b03584f5773a006
Autor:
Seik-Soon Khor, Kazuko Ueno, Nao Nishida, Minae Kawashima, Yosuke Kawai, Yoshihiro Aiba, Yuki Hitomi, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Primary biliary cholangitis (PBC) is a rare autoimmune disease with a clear predisposition for human leukocyte antigen (HLA)-DR/DQ-associated loss of immune tolerance for the E2 component of the pyruvate dehydrogenase complex. Three-field-resolution
Externí odkaz:
https://doaj.org/article/5083101fae4c4d3e8bfcee12a4a3bd7c
Autor:
Saeideh Ashouri, Seik-Soon Khor, Yuki Hitomi, Hiromi Sawai, Nao Nishida, Masaya Sugiyama, Yosuke Kawai, Nawarat Posuwan, Pisit Tangkijvanich, Piyawat Komolmit, Makoto Tsuiji, Vorasuk Shotelersuk, Yong Poovorawan, Masashi Mizokami, Katsushi Tokunaga
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
To identify novel host genetic variants that predispose to hepatitis B virus (HBV) persistence, we performed the first genome-wide association study in the Thai population involving 318 cases of chronic hepatitis B and 309 healthy controls after qual
Externí odkaz:
https://doaj.org/article/16879bbd6c0b48ecab9b35bd4103e08e
Autor:
Yosuke Kawai, Yuki Hitomi, Mayumi Ueta, Seik-Soon Khor, Ken Nakatani, Chie Sotozono, Shigeru Kinoshita, Masao Nagasaki, Katsushi Tokunaga
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract Stevens–Johnson syndrome (SJS) and its severe condition with extensive skin detachment and a poor prognosis, toxic epidermal necrolysis (TEN), are immunologically mediated severe cutaneous reactions of the skin and mucous membranes such as
Externí odkaz:
https://doaj.org/article/27bec4b4ac454684b32bc1932294c468
Autor:
Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno, Nao Nishida, Minae Kawashima, Olivier Gervais, Seik-Soon Khor, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, Makoto Tsuiji
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which intrahepatic bile ducts are destroyed by an autoimmune reaction. Our previous genome-wide association study (GWAS) identified chromosome 11q23.1 a
Externí odkaz:
https://doaj.org/article/cb5d749009044cbb96285ad674364512
Autor:
Yuki Hitomi, Minoru Nakamura
Publikováno v:
Genes, Vol 14, Iss 2, p 405 (2023)
Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which the small intrahepatic bile ducts are destroyed by autoimmune reactions. Among autoimmune diseases, which are polygenic complex traits caused by the combin
Externí odkaz:
https://doaj.org/article/ea71ed7b40644b15b6c51f10fc10630c
Autor:
Olivier Gervais, Kazuko Ueno, Yosuke Kawai, Yuki Hitomi, Kazuharu Misawa, Shunsuke Teraguchi, Yen-Yen Wang, Katsushi Tokunaga, Masao Nagasaki
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 7, Pp 2221-2228 (2020)
Over the past few decades, obesity has become a public health issue of global concern. Even though disparities exist between human populations, e.g., the higher liver fat content of the Japanese despite a lower body mass index (BMI), studies on the g
Externí odkaz:
https://doaj.org/article/38002075b3db491fab8d7425f64f5b81
Autor:
Kazuko Ueno, Yoshihiro Aiba, Yuki Hitomi, Shinji Shimoda, Hitomi Nakamura, Olivier Gervais, Yosuke Kawai, Minae Kawashima, Nao Nishida, Seik‐Soon Kohn, Kaname Kojima, Shinji Katsushima, Atsushi Naganuma, Kazuhiro Sugi, Tatsuji Komatsu, Tomohiko Mannami, Kouki Matsushita, Kaname Yoshizawa, Fujio Makita, Toshiki Nikami, Hideo Nishimura, Hiroshi Kouno, Hirotaka Kouno, Hajime Ohta, Takuya Komura, Satoru Tsuruta, Kazuhiko Yamauchi, Tatsuro Kobata, Amane Kitasato, Tamotsu Kuroki, Seigo Abiru, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi, Kiyoshi Migita, Hiromasa Ohira, Atsushi Tanaka, Hajime Takikawa, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, PBC‐GWAS Consortium in Japan
Publikováno v:
Hepatology Communications, Vol 4, Iss 5, Pp 724-738 (2020)
Genome‐wide association studies (GWASs) in European and East Asian populations have identified more than 40 disease‐susceptibility genes in primary biliary cholangitis (PBC). The aim of this study is to computationally identify disease pathways,
Externí odkaz:
https://doaj.org/article/fe46dbbb09334b3f85f5095abc8398e3
Autor:
Teruaki Oku, Yutaka Kaneko, Rie Ishii, Yuki Hitomi, Makoto Tsuiji, Satoshi Toyoshima, Tsutomu Tsuji
Publikováno v:
Biochemistry and Biophysics Reports, Vol 27, Iss , Pp 101041- (2021)
Coronin-1, a hematopoietic cell-specific actin-binding protein, is thought to be involved in the phagocytic process through its interaction with actin filaments. The dissociation of coronin-1 from phagosomes after its transient accumulation on the ph
Externí odkaz:
https://doaj.org/article/a75e3a510a054fb7aee433fe299c5a6d
Autor:
Yuki Hitomi, Ken Nakatani, Kaname Kojima, Nao Nishida, Yosuke Kawai, Minae Kawashima, Yoshihiro Aiba, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 515-532 (2019)
Background & Aims: Primary biliary cholangitis (PBC) is a chronic and cholestatic liver disease that eventually leads to cirrhosis and hepatic failure. We recently identified several susceptibility genes included NFKB1 and MANBA for PBC in the Japane
Externí odkaz:
https://doaj.org/article/7d139b2e085d4d1b96217aa1a699886e