Výsledky vyhledávání

Efficient and Scalable Asymmetric Total Synthesis of (−)-Emetine with Pharmaceutical Grade Quality; First Multigram Scale Synthesis

Autor: Masatoshi Yamada, Kazuki Azuma, Iori Takizawa, Yuki Ejima, Mitsuhisa Yamano, Kimio Satoh, Takayuki Doi, Hirofumi Ueda, Hidetoshi Tokuyama

Publikováno v: Organic Process Research & Development. 27:343-357

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b550facca8694d46740a6cd3d161defc
https://doi.org/10.1021/acs.oprd.2c00355

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Scale-up Synthesis of (R)- and (S)-N-(2-Benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide Hydrochloride, A Versatile Reagent for the Preparation of Tailor-Made α- and β-Amino Acids in an Enantiomerically Pure Form

Autor: Todd T. Romoff, Toshio Miwa, Hiroki Moriwaki, Christopher J. Creighton, Noel Mansour, Vadim A. Soloshonok, Andrew B. Palmer, Yuki Ejima

Publikováno v: Organic Process Research & Development. 21:732-739

Unusual amino acids are of crucial importance to the synthesis of bioactive peptides and new chemical entities. Innovative methodology is always needed for the preparation of enantiomerically pure amino acids that does not rely on tedious resolution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5447e5ad4691a6b34af68868b3be52f8
https://doi.org/10.1021/acs.oprd.7b00055

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