Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Yukari TOTSUKA"'
Publikováno v:
Toxins, Vol 16, Iss 8, p 331 (2024)
Pierisin is a DNA-targeting ADP-ribosyltransferase found in cabbage white butterfly (Pieris rapae). Pierisin transfers an ADP-ribosyl moiety to the 2-amino group of the guanine residue in DNA, yielding N2-(ADP-ribos-1-yl)-2′-deoxyguanosine (N2-ADPR
Externí odkaz:
https://doaj.org/article/c5efb7da2679426abe064282b34bee46
Publikováno v:
Toxins, Vol 16, Iss 6, p 270 (2024)
Pierisin-1 was serendipitously discovered as a strong cytotoxic and apoptosis-inducing protein from pupae of the cabbage butterfly Pieris rapae against cancer cell lines. This 98-kDa protein consists of the N-terminal region (27 kDa) and C-terminal r
Externí odkaz:
https://doaj.org/article/9b4c56c50807403d88844b750556d4bb
Autor:
Shugo Suzuki, Min Gi, Masami Komiya, Asuka Obikane, Arpamas Vachiraarunwong, Masaki Fujioka, Anna Kakehashi, Yukari Totsuka, Hideki Wanibuchi
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 36 (2023)
Occupational exposure to aromatic amines (AAs) is an important risk factor for urinary bladder cancer. This study aimed to evaluate the toxicity of AAs and analyze the carcinogenic mechanisms in rat bladder by comprehensive analysis of DNA adducts (D
Externí odkaz:
https://doaj.org/article/5736d78940a84bb2b95745b9e94d7678
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-7 (2020)
Abstract Introduction Kaolin is a clay mineral with the chemical composition Al2Si2O5(OH)4. It is an important industrial material, and is also used as a white cosmetic pigment. We previously reported that fine particles of kaolin have genotoxic pote
Externí odkaz:
https://doaj.org/article/55a1ee4764ec4eebb424f63e0d37d146
Autor:
Masami Komiya, Rikako Ishigamori, Mie Naruse, Masako Ochiai, Noriyuki Miyoshi, Toshio Imai, Yukari Totsuka
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Short-/middle-term and simple prediction studies for carcinogenesis are needed for the safety assessment of chemical substances. To establish a novel genotoxicity assay with an in vivo mimicking system, we prepared murine colonic/pulmonary organoids
Externí odkaz:
https://doaj.org/article/15724e95d15948518b7d967014cde8a5
Autor:
Malla Rao, Robert Hall, Kristina Lu, Robin Mason, Gayle Bernabe, Patrick Brennan, Wolfgang Leitner, Christian Abnet, Kumiko Tsukui, Koji Yahara, Masahiro Yamamoto, Chie Nakajima, Yukari Totsuka
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 11, Pp - (2019)
Externí odkaz:
https://doaj.org/article/a2215bd3ddd244199b6b75cacaad05d0
Autor:
Tatsuya Kato, Tatsushi Toyooka, Yuko Ibuki, Shuichi Masuda, Masatoshi Watanabe, Yukari Totsuka
Publikováno v:
Genes and Environment, Vol 39, Iss 1, Pp 1-10 (2017)
Abstract Background Kaolin is white clay mineral with the chemical composition Al2Si2O5(OH)4, and many varieties of kaolins having different crystal structures are utilized in industrial, cosmetic and medical fields. To evaluate the effect of physico
Externí odkaz:
https://doaj.org/article/0e271159716b4eb1852a72f5189ac1e9
Autor:
Kousuke Ishino, Tatsuya Kato, Mamoru Kato, Tatsuhiro Shibata, Masatoshi Watanabe, Keiji Wakabayashi, Hitoshi Nakagama, Yukari Totsuka
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 2, Pp 3474-3492 (2015)
Nanosized-magnetite (MGT) is widely utilized in medicinal and industrial fields; however, its toxicological properties are not well documented. In our previous report, MGT showed genotoxicity in both in vitro and in vivo assay systems, and it was sug
Externí odkaz:
https://doaj.org/article/a5bf506180994b338498ac30579fb09f
Autor:
Yukari Totsuka, Kousuke Ishino, Tatsuya Kato, Sumio Goto, Yukie Tada, Dai Nakae, Masatoshi Watanabe, Keiji Wakabayashi
Publikováno v:
Nanomaterials, Vol 4, Iss 1, Pp 175-188 (2014)
Nanomaterials are useful for their characteristic properties and are commonly used in various fields. Nanosized-magnetite (MGT) is widely utilized in medicinal and industrial fields, whereas their toxicological properties are not well documented. A s
Externí odkaz:
https://doaj.org/article/3b9e75a2f16e4d07bcf73eb8abdc4595
Autor:
Takahiro Kochi, Masahito Shimizu, Yukari Totsuka, Yohei Shirakami, Takayuki Nakanishi, Tetsushi Watanabe, Takuji Tanaka, Hitoshi Nakagama, Keiji Wakabayashi, Hisataka Moriwaki
Publikováno v:
Toxicology Reports, Vol 1, Iss C, Pp 69-73 (2014)
The benzoazepinoqunolinone derivative, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), which is produced in a mixture of glucose and tryptophan incubated at 37 °C under physiological conditions in the presence or absence of hy
Externí odkaz:
https://doaj.org/article/a5b465d976624acea86af21890986951