Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Yukari Shigemoto-Mogami"'
Publikováno v:
Frontiers in Neuroanatomy, Vol 18 (2024)
The blood–brain barrier (BBB) blocks harmful substances from entering the brain and dictates the central nervous system (CNS)-specific pharmacokinetics. Recent studies have shown that perivascular astrocytes and microglia also control BBB functions
Externí odkaz:
https://doaj.org/article/f8d7c493500b43c0b72bc45205182e0f
Autor:
Kimiko Nakayama-Kitamura, Yukari Shigemoto-Mogami, Hiroko Toyoda, Ikue Mihara, Hiroyuki Moriguchi, Hitoshi Naraoka, Tomomi Furihata, Seiichi Ishida, Kaoru Sato
Publikováno v:
Regenerative Therapy, Vol 22, Iss , Pp 192-202 (2023)
Microphysiological system (MPS), a new technology for in vitro testing platforms, have been acknowledged as a strong tool for drug development. In the central nervous system (CNS), the blood‒brain barrier (BBB) limits the permeation of circulating
Externí odkaz:
https://doaj.org/article/3a7be36fbabe4fde848f665ea305901f
Autor:
Marie Piantino, Dong-Hee Kang, Tomomi Furihata, Noriyuki Nakatani, Kimiko Kitamura, Yukari Shigemoto-Mogami, Kaoru Sato, Michiya Matsusaki
Publikováno v:
Materials Today Bio, Vol 15, Iss , Pp 100324- (2022)
The blood-brain barrier (BBB), a selective barrier regulating the active and passive transport of solutes in the extracellular fluid of the central nervous system, prevents the delivery of therapeutics for brain disorders. The BBB is composed of brai
Externí odkaz:
https://doaj.org/article/91879e6a664447e7a2da6afe505e0ac9
Autor:
Marie Piantino, Fiona Louis, Yukari Shigemoto-Mogami, Kimiko Kitamura, Kaoru Sato, Tomoko Yamaguchi, Kenji Kawabata, Syunsuke Yamamoto, Shinji Iwasaki, Hideki Hirabayashi, Michiya Matsusaki
Publikováno v:
Materials Today Bio, Vol 14, Iss , Pp 100232- (2022)
The blood-brain barrier (BBB), a selective barrier formed by brain microvascular endothelial cells (BMEC), represents a major challenge for the efficient accumulation of pharmaceutical drugs into the brain. The receptor-mediated transcytosis (RMT) ha
Externí odkaz:
https://doaj.org/article/59de46fe30574805a1f2d16bcb8a2d57
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Severe neuroinflammation is associated with blood brain barrier (BBB) disruption in CNS diseases. Although microglial activation and the subsequent changes in cytokine/chemokine (C/C) concentrations are thought to be key steps in the development of n
Externí odkaz:
https://doaj.org/article/7090aa3f9aca471abb07912bea94c91a
Autor:
Koki Fujimori, Junpei Takaki, Yukari Shigemoto-Mogami, Yuko Sekino, Takeshi Suzuki, Kaoru Sato
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 1, Pp 145-149 (2015)
The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We th
Externí odkaz:
https://doaj.org/article/425aecdcfcbb4c968d7ad72c5651b6ae
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
The in vitro use of neurons that are differentiated from human induced pluripotent stem cells (hiPSC-neurons) is expected to improve the prediction accuracy of preclinical tests for both screening and safety assessments in drug development. To achiev
Externí odkaz:
https://doaj.org/article/c20a356e49754ec9935bd3d89a09c592
Autor:
Kaoru Sato, Yukari Shigemoto-Mogami
Publikováno v:
YAKUGAKU ZASSHI. 141:359-368
Microglia are immune cells resident in the central nervous system (CNS). It has been gradually clarified that microglia play various roles at the developmental stage of the CNS. From embryonic to early postnatal age, microglia remove apoptotic cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20eac939ee349215b3e5e9490cbef026
https://doi.org/10.1248/yakushi.20-00198-4
https://doi.org/10.1248/yakushi.20-00198-4
Autor:
Marie, Piantino, Fiona, Louis, Yukari, Shigemoto-Mogami, Kimiko, Kitamura, Kaoru, Sato, Tomoko, Yamaguchi, Kenji, Kawabata, Syunsuke, Yamamoto, Shinji, Iwasaki, Hideki, Hirabayashi, Michiya, Matsusaki
Publikováno v:
Materials today. Bio. 14
The blood-brain barrier (BBB), a selective barrier formed by brain microvascular endothelial cells (BMEC), represents a major challenge for the efficient accumulation of pharmaceutical drugs into the brain. The receptor-mediated transcytosis (RMT) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f17a592ca27a10477925dd9c986d7c59
https://pubmed.ncbi.nlm.nih.gov/35308041
https://pubmed.ncbi.nlm.nih.gov/35308041
Autor:
Yukari, Shigemoto-Mogami, Kaoru, Sato
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 141(3)
Microglia are immune cells resident in the central nervous system (CNS). It has been gradually clarified that microglia play various roles at the developmental stage of the CNS. From embryonic to early postnatal age, microglia remove apoptotic cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7760d40bf2c1bcddb4322db7c866eb8f
https://pubmed.ncbi.nlm.nih.gov/33642504
https://pubmed.ncbi.nlm.nih.gov/33642504