Výsledky vyhledávání - "Yukako Tachibana-Kondo"

Supplementary Table S3 from Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Autor: Toshiyuki Sakai, Yuko Aoki, Neal Rosen, Poulikos I. Poulikakos, Yoshihiro Sowa, Mikio Arisawa, Nobuo Shimma, Toshihiro Aoki, Hitoshi Iikura, Yukako Tachibana-Kondo, Yasushi Tomii, Yutaka Matsuda, Hiroshi Sakamoto, Takaaki Miura, Kazuhiro Ohara, Eric W. Joseph, Naoki Harada, Nobuya Ishii

Supplementary Table S3 - PDF file 54K, Binding constant between CH5126766 and non-phosphorylated MEK1. Non-phosphorylated His6-MEK1 (WT) was imobilized and affinities between His6-MEK1 and MEK inhibitors were analyzed with SPR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5f67b52f9034817d856805e70d2d99
https://doi.org/10.1158/0008-5472.22395615

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Data from Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Tumors with mutant RAS are often dependent on extracellular signal–regulated kinase (ERK) signaling for growth; however, MEK inhibitors have only marginal antitumor activity in these tumors. MEK inhibitors relieve ERK-dependent feedback inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6d6624da24b766920d5ee7c74276a2
https://doi.org/10.1158/0008-5472.c.6504354.v1

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Supplementary Figure S1 from Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Supplementary Figure S1 - PDF file 70K, Induction of p27Kip1 protein and cell cycle arrest by CH5126766

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b272c3326137d6cf173146780cfce50
https://doi.org/10.1158/0008-5472.22395636.v1

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Supplementary Materials and Methods from Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Supplementary Materials and Methods - PDF file 65K, Antibodies and kinase panel assays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d3675432925f1de4e4eff25dee105c
https://doi.org/10.1158/0008-5472.22395624

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Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Autor: Yasushi Tomii, Hiroshi Sakamoto, Toshihiro Aoki, Kazuhiro Ohara, Poulikos I. Poulikakos, Yoshihiro Sowa, Nobuo Shimma, Yuko Aoki, Neal Rosen, Mikio Arisawa, Yukako Tachibana-Kondo, Nobuya Ishii, Eric W. Joseph, Hitoshi Iikura, Naoki Harada, Toshiyuki Sakai, Takaaki Miura, Yutaka Matsuda

Publikováno v: Cancer Research. 73:4050-4060

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9319805b9b026830a7ef25bec51d707f
https://doi.org/10.1158/0008-5472.can-12-3937

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Abstract 2729: FGFR genetic alterations as a potential predictor of the sensitivity to CH5183284/Debio 1347, a selective FGFR inhibitor with a novel chemical scaffold

Autor: Takehito Isobe, Yasuko Sato, Kenji Morikami, Nobuya Ishii, Hitoshi Sase, Nukinori Akiyama, Yoshito Nakanishi, Yukako Tachibana-Kondo, Hirosato Ebiike, Hidetoshi Shindoh, Toshiyuki Mio, Kiyoaki Sakata, Toshihiko Fujii, Naoki Taka, Yuko Aoki, Toshiyuki Tsukaguchi

Publikováno v: Cancer Research. 74:2729-2729

The fibroblast growth factor receptors (FGFR) are tyrosine kinases that are constitutively activated in a subset of tumors by genetic alterations such as gene amplification, point mutation, or chromosomal translocation/rearrangement. Recently, small-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b11d5dd63c9bf8c616413044a0ad841a
https://doi.org/10.1158/1538-7445.am2014-2729

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Abstract 3606: CH5126766 is a novel allosteric inhibitor of MEK that prevents its phosphorylation by RAF

Autor: Yukako Tachibana-Kondo, Poulikos I. Poulikakos, Toshihiro Aoki, Hitoshi Iikura, Nobuo Shimma, Nobuya Ishii, Yuko Aoki, Yasushi Tomii, Neal Rosen, Hiroshi Sakamoto, Toshiyuki Sakai, Kazuhiro Ohara, Yoshihiro Sowa, Mikio Arisawa, Eric W. Joseph, Takaaki Miura, Yutaka Matsuda, Naoki Harada

Publikováno v: Cancer Research. 71:3606-3606

Tumors with mutant BRAF or RAS are often dependent on the ERK signaling pathway. MEK and RAF inhibitors have significant antitumor activity in patients with BRAF mutant melanoma, but, thus far, MEK inhibitors have little activity in patients whose tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b5ac21e27d393217c21bb4a533d151a
https://doi.org/10.1158/1538-7445.am2011-3606

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Akademický článek

Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity.

Autor: Nobuya Ishii¹, Naoki Harada¹, Joseph, Eric W.², Kazuhiro Ohara¹, Takaaki Miura¹, Hiroshi Sakamoto¹, Yutaka Matsuda¹, Yasushi Tomii¹, Yukako Tachibana-Kondo¹, Hitoshi Iikura¹, Toshihiro Aoki¹, Nobuo Shimma¹, Mikio Arisawa¹, Yoshihiro Sowa³, Poulikakos, Poulikos I.², Rosen, Neal² rosenn@mskcc.org, Yuko Aoki¹, Toshiyuki Sakai³

Publikováno v: Cancer Research. Jul2013, Vol. 73 Issue 13, p4050-4060. 11p.

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