Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Yuka W, Iwasaki"'
Autor:
Hiromi Yamada, Kazumichi M. Nishida, Yuka W. Iwasaki, Yosuke Isota, Lumi Negishi, Mikiko C. Siomi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Siwi-piRISC protects the germline genome from DNA damage caused by selfish movement of transposons by suppressing their expression. Here, the authors show how molecularly Papi, which plays an important role in the production of Siwi-piRISC, cooperate
Externí odkaz:
https://doaj.org/article/25e88a75d92b4be1a12a3a1045ee983f
Autor:
Kodai Abe, Yasuaki Kabe, Susumu Uchiyama, Yuka W. Iwasaki, Hirotsugu Ishizu, Yoshifumi Uwamino, Toshiki Takenouchi, Shunsuke Uno, Makoto Ishii, Takahiro Maruno, Masanori Noda, Mitsuru Murata, Naoki Hasegawa, Hideyuki Saya, Yuko Kitagawa, Koichi Fukunaga, Masayuki Amagai, Haruhiko Siomi, Makoto Suematsu, Kenjiro Kosaki, Keio Donner Project
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Recently, an international randomized controlled clinical trial showed that patients with SARS-CoV-2 infection treated orally with the 3-chymotrypsin-like protease (3CLpro) inhibitor PF-07321332 within three days of symptom onset showed an 8
Externí odkaz:
https://doaj.org/article/8ef1022f02d640c294d513705ddd8c3a
Autor:
Yurika Namba, Yuka W. Iwasaki, Kazumichi M. Nishida, Hidenori Nishihara, Tetsutaro Sumiyoshi, Mikiko C. Siomi
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103914- (2022)
Summary: PIWI-interacting RNAs (piRNAs) bind to PIWI proteins to assemble the piRISC, which represses germline transposons. Maelstrom (Mael) is necessary for piRISC biogenesis in germ cells, but its function remains unclear. Here, we show that Mael i
Externí odkaz:
https://doaj.org/article/db07349de2f149349d5428e9be6ab5fe
Autor:
Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W. Iwasaki
Publikováno v:
Nucleic Acids Research. 50:11580-11599
SummaryTelomeres in Drosophila are composed of sequential non-LTR retrotransposons: HeT-A, TART, and TAHRE. Although they are repressed by the piRNA pathway in the germline, how these retrotransposons are regulated in somatic cells is poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cadc82c98776bc69b03fee7ffd84cc
https://doi.org/10.1093/nar/gkac1034
https://doi.org/10.1093/nar/gkac1034
Autor:
Yuka W. Iwasaki, Hidetoshi Hasuwa, Hiroyuki Sasaki, Harumi Masuda, Wan Kin Au Yeung, Haruhiko Siomi, Kyoko Ishino
Publikováno v:
Nature Cell Biology. 23:1002-1012
Many animals have a conserved adaptive genome defence system known as the Piwi-interacting RNA (piRNA) pathway, which is essential for germ cell development and function. Disruption of individual mouse Piwi genes results in male but not female steril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398df156fbd1d3d7233cd842bf2ee38e
https://doi.org/10.1038/s41556-021-00745-3
https://doi.org/10.1038/s41556-021-00745-3
Autor:
Hirotsugu Ishizu, Yuka W. Iwasaki, Shigeki Hirakata, Haruka Ozaki, Wataru Iwasaki, Haruhiko Siomi, Mikiko C. Siomi
Publikováno v:
Cell Reports, Vol 12, Iss 3, Pp 429-440 (2015)
Primary piRNAs in Drosophila ovarian somatic cells arise from piRNA cluster transcripts and the 3′ UTRs of a subset of mRNAs, including Traffic jam (Tj) mRNA. However, it is unclear how these RNAs are determined as primary piRNA sources. Here, we i
Externí odkaz:
https://doaj.org/article/6fe840c429434b18ba1ef4c962f0d129
Autor:
Kazumichi M. Nishida, Yuka W. Iwasaki, Yukiko Murota, Akihiro Nagao, Taro Mannen, Yumiko Kato, Haruhiko Siomi, Mikiko C. Siomi
Publikováno v:
Cell Reports, Vol 10, Iss 2, Pp 193-203 (2015)
PIWI-interacting RNA (piRNA) biogenesis consists of two sequential steps: primary piRNA processing and the ping-pong cycle that depends on reciprocal Slicer-mediated RNA cleavage by PIWI proteins. However, the molecular functions of the factors invol
Externí odkaz:
https://doaj.org/article/41f41e708c004047b3742b8f78b88269
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2509
Transposable elements (TEs) constitute a large proportion of the genome in multiple organisms. Therefore, anti-transposable element machineries are essential to maintain genomic integrity. PIWI-interacting RNAs (piRNAs) are a major force to repress T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9b51d2c02680bfebc710a95f7422f64
https://pubmed.ncbi.nlm.nih.gov/35796962
https://pubmed.ncbi.nlm.nih.gov/35796962
Autor:
Yukiko Murota, Hirotsugu Ishizu, Shinichi Nakagawa, Yuka W. Iwasaki, Shinsuke Shibata, Miharu K. Kamatani, Kuniaki Saito, Hideyuki Okano, Haruhiko Siomi, Mikiko C. Siomi
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 103-113 (2014)
PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells. piRNA maturation and association with Piwi occur at perinuclear Yb bodies, the centers of piRNA biogenesis. Here, we
Externí odkaz:
https://doaj.org/article/181a8b5f05b140e1aa21178d90b47794
Autor:
Yuka W. Iwasaki, Hitoshi Ohtani
Publikováno v:
Development, Growth & Differentiation. 63:262-273
Transposable elements form a major fraction of the genome in various eukaryotic species. Although deleterious effects of transpositions within the genome have been reported, recent findings suggest that transposable elements can function as novel reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709b00219f1e856b6ed3c18656124c9e
https://doi.org/10.1111/dgd.12735
https://doi.org/10.1111/dgd.12735