Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yuka Machida"'
Autor:
Sowmiya Palani, Yuka Machida, Julia R. Alvey, Vandana Mishra, Allison L. Welter, Gaofeng Cui, Benoît Bragantini, Maria Victoria Botuyan, Anh T. Q. Cong, Georges Mer, Matthew J. Schellenberg, Yuichi J. Machida
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. Missense mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic disorders with developmental defects. Despite the enzyme’
Externí odkaz:
https://doaj.org/article/04b6d5d1449d4892b6e3d297c8272f1f
Autor:
Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication for
Externí odkaz:
https://doaj.org/article/e9822e13f0724bd0b06193f6b527c895
Autor:
Scott H. Kaufmann, Thomas R. Caulfield, Sowmiya Palani, Yuka Machida, Yuichi J. Machida, Evette S. Radisky, Yusuke Kojima
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a r
Autor:
Kazuhiko Ohashi, Tomohiro Okagawa, Satoru Konnai, Shiro Murata, Naoya Maekawa, Yuka Machida, Masayoshi Isezaki
Publikováno v:
Virology Journal
Background Marek’s disease virus (MDV) causes malignant lymphomas in chickens (Marek’s disease, MD). MD is currently controlled by vaccination; however, MDV strains have a tendency to develop increased virulence. Distinct diversity and point muta
Autor:
Akira Taneno, Shiro Murata, Kazuhiko Ohashi, Ayumi Matsuyama-Kato, Satoru Konnai, Masayoshi Isezaki, Eishi Sakai, Yuka Machida
Publikováno v:
Journal of Veterinary Medical Science. 79:115-122
Gallid herpesvirus 2 (GaHV-2) causes malignant lymphomas in chickens (Marek's disease, MD). Although MD is controlled through vaccination efforts, field isolates of GaHV-2 have increased in virulence worldwide and even cause MD in vaccinated chickens
Autor:
Hyun Ja Nam, Yusuke Kojima, Reeja S. Maskey, Thomas C. Smyrk, Annyoceli Santiago, Yuka Machida, Scott H. Kaufmann, Cynthia J. Sieben, Myoung Shin Kim, Yuichi J. Machida, Karen S. Flatten, Jan M. van Deursen, Darren J. Baker, Kevin L. Peterson
Publikováno v:
Nucleic Acids Research, 45, 8, pp. 4564-4576
Nucleic Acids Research, 45, 4564-4576
Nucleic Acids Research
Nucleic Acids Research, 45, 4564-4576
Nucleic Acids Research
Contains fulltext : 174445.pdf (Publisher’s version ) (Open Access) Germline mutations in SPRTN cause Ruijs-Aalfs syndrome (RJALS), a disorder characterized by genome instability, progeria and early onset hepatocellular carcinoma. Spartan, the prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c28aa5b4b0a228b7586252dcd78dd2e
https://doi.org/10.1093/nar/gkx107
https://doi.org/10.1093/nar/gkx107
Autor:
Ajay A. Vashisht, Myoung Shin Kim, James A. Wohlschlegel, Yuan Ping Pang, Yuichi J. Machida, Yuka Machida
Publikováno v:
Nucleic Acids Research
Translesion synthesis (TLS) employs low fidelity polymerases to replicate past damaged DNA in a potentially error-prone process. Regulatory mechanisms that prevent TLS-associated mutagenesis are unknown; however, our recent studies suggest that the P
Publikováno v:
Cell Cycle. 9:3977-3983
Genome maintenance pathways correct aberrations in DNA that would be deleterious to the organism. A crucial element of many genome maintenance processes is the ability to degrade DNA that either contains errors or obscures useful substrates for recom
Publikováno v:
Molecular Biology of the Cell. 17:4837-4845
Differences in the genetic and epigenetic make up of cell lines have been very useful for dissecting the roles of specific genes in the biology of a cell. Targeted comparative RNAi (TARCOR) analysis uses high throughput RNA interference (RNAi) agains
Autor:
Anindya Dutta, Yuichi J. Machida, Yuka Machida, Alan D. D'Andrea, Yuefeng Chen, Allan M. Gurtan, Gary M. Kupfer
Publikováno v:
Molecular Cell. 23(4):589-596
The Fanconi anemia pathway is required for the efficient repair of damaged DNA. A key step in this pathway is the monoubiquitination of the FANCD2 protein by the ubiquitin ligase (E3) composed of Fanconi anemia core complex proteins. Here, we show th