Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Yuka Koike"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract In musical ensembles, people synchronise with each other despite the presence of time delays such as those related to sound transmission. However, the ways in which time delays in synchronisation are overcome remain unclear. This study aimed
Externí odkaz:
https://doaj.org/article/c48cf5d4d8514513b5f9bd6d1afe7d8d
Publikováno v:
Frontiers in Psychology, Vol 15 (2024)
We collect various types of information from our environment and organise it to create a coherent representation. Several researchers have suggested that multiple signals within the temporal binding window (TBW) can be integrated into a single cohere
Externí odkaz:
https://doaj.org/article/3a6080a6369e4f178526a450e4173dbe
Autor:
Sarah Pickles, Desiree Zanetti Alepuz, Yuka Koike, Mei Yue, Jimei Tong, Pinghu Liu, Yugui Zhou, Karen Jansen-West, Lillian M. Daughrity, Yuping Song, Michael DeTure, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, Keith A. Josephs, Dennis W. Dickson, Michael E. Ward, Lijin Dong, Mercedes Prudencio, Casey N. Cook, Leonard Petrucelli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Treatments for neurodegenerative disease, including Frontotemporal dementia (FTD) and Amyotrophic lateral sclerosis (ALS), remain rather limited, underscoring the need for greater mechanistic insight and disease-relevant models. Our ability to develo
Externí odkaz:
https://doaj.org/article/f5770006374045b4827be986a2b16eba
Autor:
Sarah Pickles, Tania F. Gendron, Yuka Koike, Mei Yue, Yuping Song, Jennifer M. Kachergus, J. Shi, Michael DeTure, E. Aubrey Thompson, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, Zbigniew K. Wszolek, Keith A. Josephs, Dennis W. Dickson, Leonard Petrucelli, Casey N. Cook, Mercedes Prudencio
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-9 (2022)
Abstract Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) is a neurodegenerative disease primarily affecting the frontal and/or temporal cortices. However, a growing body of evidence suggests that the cerebellum contributes to bioch
Externí odkaz:
https://doaj.org/article/a28be932b8a3484b87ca079966434f0a
Autor:
Yuka Koike, Sarah Pickles, Virginia Estades Ayuso, Karen Jansen-West, Yue A Qi, Ziyi Li, Lillian M Daughrity, Mei Yue, Yong-Jie Zhang, Casey N Cook, Dennis W Dickson, Michael Ward, Leonard Petrucelli, Mercedes Prudencio
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3002028 (2023)
A major function of TAR DNA-binding protein-43 (TDP-43) is to repress the inclusion of cryptic exons during RNA splicing. One of these cryptic exons is in UNC13A, a genetic risk factor for amyotrophic lateral sclerosis (ALS) and frontotemporal dement
Externí odkaz:
https://doaj.org/article/c620da5c535e493fbf35161ed1b10532
Autor:
Yuka Koike, Osamu Onodera
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective degeneration of upper and lower motor neurons. Currently, there are no effective biomarkers and fundamental therapies for this disease. Dysregulat
Externí odkaz:
https://doaj.org/article/f1bcc8e880cb473d829371296c01f276
Autor:
Yuka Koike, Akihiro Sugai, Norikazu Hara, Junko Ito, Akio Yokoseki, Tomohiko Ishihara, Takuma Yamagishi, Shintaro Tsuboguchi, Mari Tada, Takeshi Ikeuchi, Akiyoshi Kakita, Osamu Onodera
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
In order to assess the effects of aging on the autoregulation of TAR DNA-binding protein 43 (TDP-43) and the potential effects of this on the role of TDP-43 in Amyotrophic Lateral Sclerosis (ALS), Koike et al examined post-mortem motor cortex tissue
Externí odkaz:
https://doaj.org/article/b775225155e84a5488bf618023fb3c56
Autor:
Naoki Ito, Ai Takatsu, Hiromi Ito, Yuka Koike, Kiyoshi Yoshioka, Yasutomi Kamei, Shin-ichiro Imai
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111131- (2022)
Summary: Sarcopenia and frailty are urgent socio-economic problems worldwide. Here we demonstrate a functional connection between the lateral hypothalamus (LH) and skeletal muscle through Slc12a8, a recently identified nicotinamide mononucleotide tra
Externí odkaz:
https://doaj.org/article/f1a75ef1c9d54561b570b5339832c901
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating human neurodegenerative diseases. A hallmark pathological feature of both diseases is the depletion of the RNA‐binding protein TDP‐43 from the nucl
Externí odkaz:
https://doaj.org/article/f94bd40d81034c95a10c574f12b94077
Autor:
Koji Kato, Ryo Maemura, Manabu Wakamatsu, Ayako Yamamori, Motoharu Hamada, Shinsuke Kataoka, Atsushi Narita, Shunsuke Miwata, Yuko Sekiya, Nozomu Kawashima, Kyogo Suzuki, Kotaro Narita, Sayoko Doisaki, Hideki Muramatsu, Hirotoshi Sakaguchi, Kimikazu Matsumoto, Yuka Koike, Osamu Onodera, Makiko Kaga, Nobuyuki Shimozawa, Nao Yoshida
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 18, Iss , Pp 1-6 (2019)
Objective: The prognosis of adrenoleukodystrophy (ALD)with neurological involvement is generally dismal; however, allogeneic stem cell transplantation (SCT) is recognized as effective to stabilize or improve the clinical symptoms of ALD. Herein, we r
Externí odkaz:
https://doaj.org/article/2bec548df4fc4e8fbd0c4373239d7c0b