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Akademický článek

Thiamine Ameliorates Diabetes-Induced Inhibition of Pyruvate Dehydrogenase (PDH) in Rat Heart Mitochondria: Investigating the Discrepancy Between PDH Activity and PDH E1α Phosphorylation in Cardiac Fibroblasts Exposed to High Glucose

Autor: Yuka Kohda, Masashi Umeki, Tatsuji Kono, Fumio Terasaki, Hitoshi Matsumura, Takao Tanaka

Publikováno v: Journal of Pharmacological Sciences, Vol 113, Iss 4, Pp 343-352 (2010)

The activity of pyruvate dehydrogenase (PDH) is reduced in diabetic patients. Phosphorylation of the PDH E1α subunit by PDH kinase contributes to the suppression of PDH activity. PDH requires thiamine as a coenzyme. We investigated the exact mechani

Externí odkaz: https://doaj.org/article/c8e85ae83d1443c9a31a672abd3fd568

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Akademický článek

Protein O-Glycosylation Induces Collagen Expression and Contributes to Diabetic Cardiomyopathy in Rat Cardiac Fibroblasts

Autor: Yuka Kohda, Miwa Kanematsu, Tatsuji Kono, Fumio Terasaki, Takao Tanaka

Publikováno v: Journal of Pharmacological Sciences, Vol 111, Iss 4, Pp 446-450 (2009)

Diabetic cardiomyopathy may be accompanied by myocardial fibrosis. We have previously reported that cardiac fibrosis and protein O-glycosylation are elevated in diabetes. In this study, we examined if the hexosamine biosynthesis pathway (HBP) was inv

Externí odkaz: https://doaj.org/article/0834f80405904ad0bac246d7128b133c

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Akademický článek

The Effect of Antioxidant on Development of Fibrosis by Cisplatin in Rats

Autor: Yoshiko Kawai, Tomohiko Satoh, Daisuke Hibi, Yukihiro Ohno, Yuka Kohda, Katsuyuki Miura, Munekazu Gemba

Publikováno v: Journal of Pharmacological Sciences, Vol 111, Iss 4, Pp 433-439 (2009)

Cisplatin causes chronic interstitial disease with fibrosis, but the development mechanism of interstitial fibrosis is not yet understood. We examined the effect of an antioxidant, N,N’-diphenyl-1,4-phenylenediamine (DPPD), on development of inters

Externí odkaz: https://doaj.org/article/151f4bc9dcf140889ccd80a870ae2d92

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Akademický článek

Relationship of Intracellular Calcium and Oxygen Radicals to Cisplatin-Related Renal Cell Injury

Autor: Yoshiko Kawai, Takafumi Nakao, Naoshi Kunimura, Yuka Kohda, Munekazu Gemba

Publikováno v: Journal of Pharmacological Sciences, Vol 100, Iss 1, Pp 65-72 (2006)

Abstract.: We investigated the involvement of reactive oxygen species (ROS) and intracellular calcium in nephrotoxicity related to an antitumor agent, cisplatin. In this study, we employed cultured renal epithelial cells (LLC-PK1). Cisplatin at 500 �

Externí odkaz: https://doaj.org/article/41d719a535024b5ba7b49e4a68420f0c

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Akademický článek

Cephaloridine Induces Translocation of Protein Kinase C δ Into Mitochondria and Enhances Mitochondrial Generation of Free Radicals in the Kidney Cortex of Rats Causing Renal Dysfunction

Autor: Yuka Kohda, Munekazu Gemba

Publikováno v: Journal of Pharmacological Sciences, Vol 98, Iss 1, Pp 49-57 (2005)

We have previously reported that the enhancement of free radical generation in mitochondria isolated from the kidney cortex of rats exposed to cephaloridine (CER) is probably mediated by the activation of protein kinase C (PKC). We examined which iso

Externí odkaz: https://doaj.org/article/726b67b693884bfc91519975999f3aaa

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