Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yuka Ikenaga"'
Autor:
Kosuke Yoshida, Yuki Doi, Norihiko Iwazaki, Hidenori Yasuhara, Yuka Ikenaga, Hidetoshi Shimizu, Tomohisa Nakada, Tomoko Watanabe, Chise Tateno, Seigo Sanoh, Yaichiro Kotake
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 79-91 (2022)
Abstract Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokineti
Externí odkaz:
https://doaj.org/article/f898d1aa8cdb48d087447e2565b57de8
Autor:
Takahiro Oguma, Chiaki Kuriyama, Keiko Nakayama, Yasuaki Matsushita, Kumiko Yoshida, Satoko Kiuchi, Yuka Ikenaga, Yoshinobu Nakamaru, Kumiko Hikida, Akira Saito, Kenji Arakawa, Kozo Oka, Kiichiro Ueta, Masaharu Shiotani
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 4, Pp 456-461 (2015)
To assess the impact of concomitant inhibition of sodium-glucose cotransporter (SGLT) 2 and dipeptidyl peptidase IV (DPP4) for the treatment of type 2 diabetes mellitus (T2DM), the effect of combined treatment with canagliflozin, a novel SGLT2 inhibi
Externí odkaz:
https://doaj.org/article/a6e709c959c5400b8377221d633d3134
Autor:
Akihito Ogasawara, Kei Ogawa, Ryosuke Ide, Yuka Ikenaga, Chie Fukunaga, Satoshi Nakayama, Minoru Tsuda
Publikováno v:
European Journal of Clinical Pharmacology.
Purpose To describe outcomes from the first-in-human study of dersimelagon, an investigational oral selective MC1R agonist, under development for the treatment of erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). Methods In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baea94a56d47c2cc3e0cfda5803e8f8f
https://doi.org/10.1007/s00228-023-03476-6
https://doi.org/10.1007/s00228-023-03476-6
Autor:
Yuki Doi, Hidetoshi Shimizu, Hidenori Yasuhara, Seigo Sanoh, Tomoko Watanabe, Norihiko Iwazaki, Yaichiro Kotake, Chise Tateno, Yuka Ikenaga, Kosuke Yoshida, Tomohisa Nakada
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 79-91 (2022)
Clinical and Translational Science
Clinical and Translational Science
Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokinetics of suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7637d6231eb9d24c530715918ca2fe2e
https://doaj.org/article/f898d1aa8cdb48d087447e2565b57de8
https://doaj.org/article/f898d1aa8cdb48d087447e2565b57de8
Autor:
Hiromi Maune, Junichi Azuma, Masakazu Naohara, Tsuyoshi Fukuda, Kazuhiro Fukuda, Yuko Nishida, Yuka Ikenaga
Publikováno v:
Drug Metabolism and Pharmacokinetics. 20:113-116
The -1584C/G single nucleotide polymorphism (SNP) in the promoter region of CYP2D6 was suggested to have the potential to influence CYP2D6 activity. In this report, we demonstrated the frequencies of -1584C to G substitution-related alleles, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d25932b550dce65adc4c06f5aa03cd
https://doi.org/10.2133/dmpk.20.113
https://doi.org/10.2133/dmpk.20.113
Autor:
K Hoshino, T Ito, Kunio Matsumoto, S Onishi, Tsuyoshi Fukuda, Junichi Azuma, Masako Ohno, Shuichi Fukuen, Yasushi Fujio, K Momiyama, Yuka Ikenaga, A Maihara
Publikováno v:
The Pharmacogenomics Journal. 4:34-39
CYP3A5 expression is regulated by single-nucleotide polymorphisms (SNPs). The CYP3A5 genotype might contribute to a marked interindividual variation in CYP3A-mediated metabolism of drugs. Nifedipine is a typical substrate of CYP3A4 and CYP3A5 in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af2999a2387671fb9fabbc41bc43262
https://doi.org/10.1038/sj.tpj.6500218
https://doi.org/10.1038/sj.tpj.6500218
Autor:
Junichi Azuma, Yuka Ikenaga, Shuichi Fukuen, Isamu Yamamoto, Tadanobu Inaba, Hiromi Maune, Tsuyoshi Fukuda
Publikováno v:
Pharmacogenetics. 12:331-334
In this study, we established useful and reliable methods for the direct detection of the variants of CYP3A5 gene by polymerase chain reaction (PCR) and DdeI restriction analysis. The frequency of CYP3A5 related SNPs in 200 healthy Japanese male subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9000025d16f0e9cedf5de947e11fd2
https://doi.org/10.1097/00008571-200206000-00009
https://doi.org/10.1097/00008571-200206000-00009
Autor:
Alessandro Serretti, Yuka Hosoi, Laura Mandelli, Gaku Okugawa, Tsuyoshi Fukuda, Toshihiko Kinoshita, Masaki Kato, Yoshiteru Takekita, Junichi Azuma, Masataka Wakeno, Yuka Ikenaga
Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Multidrug resistance 1 (ABCB1, MDR1) gene enco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cd2f18bc3fd76524708c1d5bfb0316
http://hdl.handle.net/11585/69443
http://hdl.handle.net/11585/69443
Autor:
Tsuyoshi Fukuda, Megumi Yamashita, Masataka Wakeno, Toshihiko Kinoshita, Yuka Ikenaga, Gaku Okugawa, Kazuhiro Fukuda, Junichi Azuma, Masaki Kato, Kenji Nobuhara, Yoshiteru Takekita
Publikováno v:
Neuropsychobiology. 53(4)
In this study, we tested the influence of the serotonin type 2A, 3A and 3B receptor genes (HTR2A, HTR3A, HTR3B) in addition to a polymorphism in the promoter region of the serotonin transporter (SERTPR), and investigated the different characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690c5ff97b0e38292932133cca9a2c1b
https://pubmed.ncbi.nlm.nih.gov/16874005
https://pubmed.ncbi.nlm.nih.gov/16874005
Autor:
Junichi Azuma, Masakazu Naohara, Hiromi Maune, Yuka Ikenaga, Kazuhiro Fukuda, Tsuyoshi Fukuda
Publikováno v:
Drug metabolism and pharmacokinetics. 20(5)
We encountered DNA samples which showed a positive product using a long PCR-based method for the detection of CYP2D6*5, indicating deletion of the entire CYP2D6 gene, but the samples did not show a band related to CYP2D6*5 in either XbaI- or EcoRI-RF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca27675dad8c29aae30d92fe38bf28d
https://pubmed.ncbi.nlm.nih.gov/16272752
https://pubmed.ncbi.nlm.nih.gov/16272752