Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis

Autor: Chi‐Keung Cheng, Jennifer W. Y. Lai, Yuk‐Lin Yung, Hoi‐Yun Chan, Raymond S. M. Wong, Natalie P. H. Chan, Joyce S. Cheung, Xi Luo, Herbert‐Augustus Pitts, Margaret H. L. Ng

Publikováno v: eJHaem, Vol 3, Iss 1, Pp 184-190 (2022)

Abstract Prefibrotic primary myelofibrosis (Pre‐PMF) has been classified as a separate entity of myeloproliferative neoplasms (MPNs). Pre‐PMF is clinically heterogeneous but a specific prognostic model is lacking. Gene mutations have emerged as u

Externí odkaz: https://doaj.org/article/b0e4e21176b34979a6eda4a1d1430a6e

SPINK2 Protein Expression Is an Independent Adverse Prognostic Marker in AML and Is Potentially Implicated in the Regulation of Ferroptosis and Immune Response

Autor: Ng, Herbert Augustus Pitts, Chi-Keung Cheng, Joyce Sin Cheung, Murphy Ka-Hei Sun, Yuk-Lin Yung, Hoi-Yun Chan, Raymond S. M. Wong, Sze-Fai Yip, Ka-Ngai Lau, Wai Shan Wong, Radha Raghupathy, Natalie P. H. Chan, Margaret H. L.

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9696

There is an urgent need for the identification as well as clinicopathological and functional characterization of potent prognostic biomarkers and therapeutic targets in acute myeloid leukemia (AML). Using immunohistochemistry and next-generation sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::a9a11c0c321bc68de51f929a21a6e5f8

Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis

Autor: Chi‐Keung Cheng, Jennifer W. Y. Lai, Yuk‐Lin Yung, Hoi‐Yun Chan, Raymond S. M. Wong, Natalie P. H. Chan, Joyce S. Cheung, Xi Luo, Herbert‐Augustus Pitts, Margaret H. L. Ng

Publikováno v: eJHaem. 3:184-190

Prefibrotic primary myelofibrosis (Pre-PMF) has been classified as a separate entity of myeloproliferative neoplasms (MPNs). Pre-PMF is clinically heterogeneous but a specific prognostic model is lacking. Gene mutations have emerged as useful tools f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb716eacdd80437a17ec3657032de959
https://doi.org/10.1002/jha2.361

Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action

Autor: Michael Tim-Yun Ong, Kai-Ming Chan, Yuk-Lin Yung, Sai-Chuen Fu, Yau-Chuk Cheuk, Ling Qin, Patrick Shu-Hang Yung

Publikováno v: Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, Vol 7, Iss C, Pp 27-36 (2017)
Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology

Platelet concentrates (PC) generally refers to a group of products that are prepared from autologous blood intended to enhance healing activities. PC therapy is now very popular in treating musculoskeletal injuries; however, inconsistent clinical res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc376b6051ffc04ff2a2379e5d7a930
http://www.sciencedirect.com/science/article/pii/S221468731630293X

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Autor: Yuk-Lin Yung, Chi Keung Cheng, Nelson C N Chan, Margaret H.L. Ng, Terry H. Y. Wong

Publikováno v: Journal of Visualized Experiments.

The bulk of the human genome (~98%) is comprised of non-coding sequences. Cis-regulatory elements (CREs) are non-coding DNA sequences that contain binding sites for transcriptional regulators to modulate gene expression. Alterations of CREs have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3011a607b8b46427e70198f0322737b2
https://doi.org/10.3791/60130-v