Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Yuk-Ching Tse"'
Autor:
Ganesh Khadka, Thirunavukkarasu Annamalai, Kateel G. Shetty, Yuk-Ching Tse-Dinh, Krish Jayachandran
Publikováno v:
Microbiology Research, Vol 14, Iss 3, Pp 1470-1482 (2023)
Microorganisms associated with medicinal plants are of great interest as they are the producers of important bioactive compounds effective against common and drug-resistant pathogens. The characterization and biodiversity of fungal endophytes of the
Externí odkaz:
https://doaj.org/article/ec65b4c319214566b77ec84bda2aced3
Autor:
Kemin Tan, Yuk-Ching Tse-Dinh
Publikováno v:
Cells, Vol 13, Iss 6, p 553 (2024)
Topoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ge
Externí odkaz:
https://doaj.org/article/db0332822e9d4a85a11b827cbfa110d1
Autor:
Pamela K. Garcia, Rosemarie Martinez Borrero, Thirunavukkarasu Annamalai, Esnel Diaz, Steve Balarezo, Purushottam B. Tiwari, Yuk-Ching Tse-Dinh
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Only about half the multi-drug resistant tuberculosis (MDR-TB) cases are successfully cured. Thus, there is an urgent need of new TB treatment against a novel target. Mycobacterium tuberculosis (Mtb) topoisomerase I (TopA) is the only type IA topoiso
Externí odkaz:
https://doaj.org/article/7ae93a9175544128942c71d0bd03e5a0
Autor:
Yunke Wang, Samantha Rakela, Jeremy W. Chambers, Zi-Chun Hua, Mark T. Muller, John L. Nitiss, Yuk-Ching Tse-Dinh, Fenfei Leng
Publikováno v:
ACS Omega, Vol 4, Iss 19, Pp 18413-18422 (2019)
Externí odkaz:
https://doaj.org/article/160a7ee6f656476ca20d7340cea6570e
Autor:
Kevin Jeanne Dit Fouque, Alyssa Garabedian, Fenfei Leng, Yuk-Ching Tse-Dinh, Francisco Fernandez-Lima
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 3619-3626 (2019)
Externí odkaz:
https://doaj.org/article/4e8f38d8c1e44760b5d954fe73f1e74f
Autor:
Ahmed Seddek, Christian Madeira, Thirunavukkarasu Annamalai, Christopher Mederos, Purushottam B. Tiwari, Aaron Z. Welch, Yuk-Ching Tse-Dinh
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 3, p 093 (2022)
Background: Inhibition of human topoisomerase I (TOP1) by camptothecin and topotecan has been shown to reduce excessive transcription of PAMP (Pathogen-Associated Molecular Pattern)-induced genes in prior studies, preventing death from sepsis in anim
Externí odkaz:
https://doaj.org/article/a5a995c5bb174cdc8f76ee83b4112e47
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
In vivo, complex topologies have been identified in proteins and DNA, while their existence in RNA is still unclear. Here, the authors design synthetic topological structures containing single stranded RNA, offering tools for investigating biological
Externí odkaz:
https://doaj.org/article/1c7ba95f4d1044cca451a924ba109076
Autor:
Pamela K Garcia, Thirunavukkarasu Annamalai, Wenjie Wang, Raven S Bell, Duc Le, Paula Martin Pancorbo, Sabah Sikandar, Ahmed Seddek, Xufen Yu, Dianqing Sun, Anne-Catrin Uhlemann, Purushottam B Tiwari, Fenfei Leng, Yuk-Ching Tse-Dinh
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0207733 (2019)
We have previously reported the inhibition of bacterial topoisomerase I activity by a fluoroquinophenoxazine compound (FP-11g) with a 6-bipiperidinyl lipophilic side chain that exhibited promising antituberculosis activity (MIC = 2.5 μM against Myco
Externí odkaz:
https://doaj.org/article/d9bfda57d9f048fe980faa0d20768f76
Publikováno v:
Microorganisms, Vol 9, Iss 1, p 86 (2021)
Infectious diseases are one of the main causes of death all over the world, with antimicrobial resistance presenting a great challenge. New antibiotics need to be developed to provide therapeutic treatment options, requiring novel drug targets to be
Externí odkaz:
https://doaj.org/article/b8623b177f4341dc84be7e5f0ba5c5a4
Publikováno v:
Molecules, Vol 25, Iss 20, p 4769 (2020)
Topoisomerases in the type IA subfamily can catalyze change in topology for both DNA and RNA substrates. A type IA topoisomerase may have been present in a last universal common ancestor (LUCA) with an RNA genome. Type IA topoisomerases have since ev
Externí odkaz:
https://doaj.org/article/a237a29a3624482e95908b163b763b20