Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yuk Pheel Park"'
Autor:
Minghao Gong, Seung-Chul Choi, Yuk Pheel Park, Xueyang Zou, Ahmed S. Elshikha, Valerie A. Gerriets, Jeffrey C. Rathmell, Mansour Mohamazadeh, Laurence Morel
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106774- (2023)
Summary: The expansion of follicular helper T (Tfh) cells, which is tightly associated with the development of lupus, is reversed by the inhibition of either glycolysis or glutaminolysis in mice. Here we analyzed the gene expression and metabolome of
Externí odkaz:
https://doaj.org/article/777af55b261642a996bb8a26db066cb2
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1)
Autor:
Chieko Michikawa, Vancheswaran Gopalakrishnan, Amani M. Harrandah, Tatiana V Karpinets, Rekha Rani Garg, Randy A. Chu, Yuk Pheel Park, Sasanka S. Chukkapallia, Nikhita Yadlapalli, Kelly C. Erikson-Carter, Frederico Omar Gleber-Netto, Elias Sayour, Ann Progulske-Fox, Edward K.L. Chan, Xiaogang Wu, Jianhua Zhang, Christian Jobin, Jennifer A. Wargo, Curtis R. Pickering, Jeffrey N. Myers, Natalie Silver
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 31, Iss , Pp 100813- (2022)
Recently, increased number of studies have demonstrated a relationship between the oral microbiome and development of head and neck cancer, however, there are few studies to investigate the role of oral bacteria in the context of the tumor microenvir
Externí odkaz:
https://doaj.org/article/974eabb64e8544b885cd3daac2802a36
Autor:
Wei Li, Minghao Gong, Yuk Pheel Park, Ahmed S. Elshikha, Seung-Chul Choi, Josephine Brown, Nathalie Kanda, Wen-I Yeh, Leeana Peters, Anton A. Titov, Xiangyu Teng, Todd M. Brusko, Laurence Morel
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Estrogen-related receptor γ (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls Tregs through mitochondria homeostasis. Esrrg deficiency impaired the maintenance and function of Tregs,
Externí odkaz:
https://doaj.org/article/50322e943b384bb5b68296e20da82369
Autor:
Georges Abboud, Seung-Chul Choi, Xiaojuan Zhang, Yuk Pheel Park, Nathalie Kanda, Leilani Zeumer-Spataro, Morgan Terrell, Xiangyu Teng, Kirsten Nündel, Mark J. Shlomchik, Laurence Morel
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950).
The activation of lymphocytes in patients with lupus and in mouse models of the disease is coupled with an increased cellular metabolism in which glucose plays a major role. The pharmacological inhibition of glycolysis with 2-deoxy-d-glucose (2DG) re
Autor:
Xiangyu Teng, Wei Li, Anton A. Titov, Josephine Brown, Leeana D. Peters, Wen-I Yeh, Nathalie Kanda, Minghao Gong, Todd M. Brusko, Yuk Pheel Park, Seung-Chul Choi, Laurence Morel, Ahmed S. Elshikha
Publikováno v:
JCI Insight
Estrogen-related receptor gamma (Esrrg) is a murine lupus susceptibility gene associated with T cell activation. Here, we report that Esrrg controls regulatory T cells (Treg) through mitochondria homeostasis. Esrrg deficiency impaired the maintenance
Publikováno v:
The Journal of Immunology. 208:103.01-103.01
Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which poorly characterized genetic factors lead to the production of autoreactive or inflammatory T cells. Pre-B cell leukemia homeobox 1 (Pbx1) is a transcription factor whose dominant n
Homeodomain protein Pbx1 regulates regulatory T cell development, stability and suppressive function
Publikováno v:
The Journal of Immunology. 208:44.08-44.08
Pre-B cell leukemia transcription factor 1 (Pbx1) regulates multiple processes in various cell types. The Pbx1 gene is located in the Sle1a1 lupus susceptibility locus in the NZM2410 lupus-prone mouse model. The Pbx1-d dominant negative isoform lacki
Autor:
Katie B. Bennett, Edward K. L. Chan, Lung-Ji Chang, Linchun Jin, Jianping Huang, Yuk Pheel Park, Kristianna Fredenburg, Jennifer Tseng, Dunrui Wang
Publikováno v:
Oral Oncology. 78:145-150
Objectives In accordance with the Precision Medicine Initiative, new treatment strategies for head and neck squamous cell carcinoma (HNSCC) are needed to yield better therapeutic outcomes. The purpose of this study was to establish and validate chime
Autor:
Yuk Pheel Park, Sasanka S. Chukkapalli, Rekha Rani Grag, Edward K. L. Chan, Natalie L. Silver, Amani Harrandah, Nikhita Yadlapalli
Publikováno v:
Cancer Research. 80:A10-A10
Objectives: Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide with a poor prognosis of ~40% at 5 years for HPV-negative disease. Recently, immune checkpoint inhibitors (specifically, anti-PD-1 checkpoint inhibitors
Autor:
Do Young Yoon, Jong-Tae Kim, Yuk Pheel Park, Young Yang, Jong-Seok Lim, Hee Gu Lee, Jong Wan Kim
Publikováno v:
Annals of Laboratory Medicine. 28:230-238
Background Mac-2 binding protein (Mac-2BP) is a secreted glycoprotein from the culture fluid of several human cancer cells, especially breast, lung, and gastric cells. Mac-2BP plays a role in immune response and cell adhesion activity in patients wit