Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yuk Peng Wong"'
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The CACNA1C (calcium voltage-gated channel subunit alpha 1 C) gene that encodes the CaV1.2 channel is a prominent risk gene for neuropsychiatric and neurodegenerative disorders with cognitive and social impairments like schizophrenia, bipola
Externí odkaz:
https://doaj.org/article/dd73fb88640c468987fe77c0e7a05eb1
Autor:
Dejie Yu, Xiaoyuan Wang, Jiong-Wei Wang, Jia Lin Soon, Zhenyu Hu, Yuk Peng Wong, Tuck Wah Soong, Henry M. Colecraft, Ping Liao, Suet Yen Chong, Guang Li, Mui Cheng Liang, Na Huang
Publikováno v:
Circulation. 138:1431-1445
Background: L-type Ca V 1.2 channels play crucial roles in the regulation of blood pressure. Galectin-1 (Gal-1) has been reported to bind to the I-II loop of Ca V 1.2 channels to reduce their current density. However, the mechanistic understanding fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ced2fa91fcaf6c96a03443ec8708b6e
https://doi.org/10.1161/circulationaha.117.031231
https://doi.org/10.1161/circulationaha.117.031231
Autor:
Ping Liao, Yuk Peng Wong, Uta C. Hoppe, Juejin Wang, Tuck Wah Soong, Mui Cheng Liang, Dejie Yu, Guang Li, Tan Fong Yong, Roger Foo
Publikováno v:
Channels. 12:51-57
Recently, we reported that homozygous deletion of alternative exon 33 of CaV1.2 calcium channel in the mouse resulted in ventricular arrhythmias arising from increased CaV1.2Δ33 ICaL current density in the cardiomyocytes. We wondered whether heteroz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c1ecf0b663bedacd6f4db0f7c40366
https://doi.org/10.1080/19336950.2017.1381805
https://doi.org/10.1080/19336950.2017.1381805
Autor:
Nimmi Baby, Sreedharan Sajikumar, Yuk Peng Wong, Muhammad Hakim, Ananya Dasgupta, Thomas Behnisch, Kumar Krishna, Tuck Wah Soong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(41)
The hippocampal area Cornu Ammonis (CA) CA2 is important for social interaction and is innervated by Substance P (SP)-expressing supramammillary (SuM) nucleus neurons. SP exerts neuromodulatory effects on pain processing and central synaptic transmis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ee0f2003fc054b0ab531eaa0f00575
https://pubmed.ncbi.nlm.nih.gov/28973908
https://pubmed.ncbi.nlm.nih.gov/28973908
Autor:
Juejin, Wang, Guang, Li, Dejie, Yu, Yuk Peng, Wong, Tan Fong, Yong, Mui Cheng, Liang, Ping, Liao, Roger, Foo, Uta C, Hoppe, Tuck Wah, Soong
Publikováno v:
Channels
Recently, we reported that homozygous deletion of alternative exon 33 of CaV1.2 calcium channel in the mouse resulted in ventricular arrhythmias arising from increased CaV1.2Δ33 ICaL current density in the cardiomyocytes. We wondered whether heteroz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eab0dfbd08ea69111895a92dbadb6dd7
https://pubmed.ncbi.nlm.nih.gov/28949795
https://pubmed.ncbi.nlm.nih.gov/28949795
Autor:
Guang, Li, Juejin, Wang, Ping, Liao, Peter, Bartels, Hengyu, Zhang, Dejie, Yu, Mui Cheng, Liang, Kian Keong, Poh, Chye Yun, Yu, Fengli, Jiang, Tan Fong, Yong, Yuk Peng, Wong, Zhenyu, Hu, Hua, Huang, Guangqin, Zhang, Mary Joyce, Galupo, Jin-Song, Bian, Sathivel, Ponniah, Scott Lee, Trasti, Kelvin, See, Roger, Foo, Uta C, Hoppe, Stefan, Herzig, Tuck Wah, Soong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(21)
To directly address in vivo significance of the altered CaV1.2 channel property arising from alternative splicing, we generated CaV1.2 exon 33-specific knockout (exon 33−/−) mice. Here, we showed that the exclusion of alternative exon 33 altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fde7935dc7896b1aa58e14dc2f27262
https://pubmed.ncbi.nlm.nih.gov/28490495
https://pubmed.ncbi.nlm.nih.gov/28490495
Autor:
Yuk Peng Wong, Jin-Song Bian, Mary Joyce Galupo, Sathivel Ponniah, Juejin Wang, Chye Yun Yu, Peter Bartels, Uta C. Hoppe, Guang Li, Dejie Yu, Stefan Herzig, Fengli Jiang, Mui Cheng Liang, Ping Liao, Hua Huang, Guangqin Zhang, Kelvin See, Kian Keong Poh, Hengyu Zhang, Scott L. Trasti, Roger Foo, Tuck Wah Soong, Zhenyu Hu, Tan Fong Yong
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Alternative splicing changes the CaV1.2 calcium channel electrophysiological property, but the in vivo significance of such altered channel function is lacking. Structure-function studies of heterologously expressed CaV1.2 channels could not recapitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e6f1a9511930b1886a4d6771419e5a
https://doi.org/10.1073/pnas.1617205114
https://doi.org/10.1073/pnas.1617205114
Autor:
Sophia S.H. Yang, Yuk Peng Wong, Shengnan Li, Chye Yun Yu, Ping Liao, Dejie Yu, Juejin Wang, Tuck Wah Soong, Sharon S.C. Thio
Publikováno v:
Circulation research. 109(11)
Rationale: Ca V 1.2 channels are essential for excitation–contraction coupling in the cardiovascular system, and alternative splicing optimizes its role. Galectin-1 (Gal-1) has been reported to regulate vascular smooth muscle cell (VSMC) function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f1eae9c51afc558a81b0463d27bf17
https://pubmed.ncbi.nlm.nih.gov/21998324
https://pubmed.ncbi.nlm.nih.gov/21998324
Autor:
Dasgupta, Ananya, Baby, Nimmi, Krishna, Kumar, Hakim, Muhammad, Yuk Peng Wong, Behnisch, Thomas, Tuck Wah Soong, Sajikumar, Sreedharan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 10/10/2017, Vol. 114 Issue 41, pE8741-E8749, 9p
Autor:
Guang Li, Juejin Wang, Ping Liao, Bartels, Peter, Hengyu Zhang, Dejie Yu, Mui Cheng Liang, Kian Keong Poh, Chye Yun Yu, Fengli Jiang, Tan Fong Yong, Yuk Peng Wong, Zhenyu Hu, Hua Huang, Guangqin Zhang, Galupo, Mary Joyce, Jin-Song Bian, Ponniah, Sathivel, Trasti, Scott Lee, See, Kelvin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/23/2017, Vol. 114 Issue 21, pE4288-E4295, 8p