Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Yuk Kien Chong"'
Autor:
Melanie Si Yan Tan, Edwin Sandanaraj, Yuk Kien Chong, See Wee Lim, Lynnette Wei Hsien Koh, Wai Hoe Ng, Nguan Soon Tan, Patrick Tan, Beng Ti Ang, Carol Tang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
STAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy.
Externí odkaz:
https://doaj.org/article/d61c46f20a3c44179f855b1383771751
Autor:
Kah-Leong Lim, Carol Tang, Ryosuke Takahashi, Beng-Ti Ang, Joanna D. Holbrook, Edwin Sandanaraj, Charlene S.F. Foong, Lynnette W.H. Koh, Yuk Kien Chong, Geraldene R.H. Koh, Jeanne M.M. Tan, Chou Chai, Felicia S.L. Ng, Calvin W.S. Yeo
Mutations in the parkin gene, which encodes a ubiquitin ligase, are a major genetic cause of parkinsonism. Interestingly, parkin also plays a role in cancer as a putative tumor suppressor, and the gene is frequently targeted by deletion and inactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb9f03b215b799e214de69512817fed
https://doi.org/10.1158/0008-5472.c.6502959.v1
https://doi.org/10.1158/0008-5472.c.6502959.v1
Autor:
Kah-Leong Lim, Carol Tang, Ryosuke Takahashi, Beng-Ti Ang, Joanna D. Holbrook, Edwin Sandanaraj, Charlene S.F. Foong, Lynnette W.H. Koh, Yuk Kien Chong, Geraldene R.H. Koh, Jeanne M.M. Tan, Chou Chai, Felicia S.L. Ng, Calvin W.S. Yeo
PDF file - 64K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe96a3645ea7acb872fd18ed47676d7
https://doi.org/10.1158/0008-5472.22390458
https://doi.org/10.1158/0008-5472.22390458
Autor:
Kah-Leong Lim, Carol Tang, Ryosuke Takahashi, Beng-Ti Ang, Joanna D. Holbrook, Edwin Sandanaraj, Charlene S.F. Foong, Lynnette W.H. Koh, Yuk Kien Chong, Geraldene R.H. Koh, Jeanne M.M. Tan, Chou Chai, Felicia S.L. Ng, Calvin W.S. Yeo
PDF file - 130K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0baf99cb3a4d8497ec067cc57d1b906e
https://doi.org/10.1158/0008-5472.22390461.v1
https://doi.org/10.1158/0008-5472.22390461.v1
Autor:
Kah-Leong Lim, Carol Tang, Ryosuke Takahashi, Beng-Ti Ang, Joanna D. Holbrook, Edwin Sandanaraj, Charlene S.F. Foong, Lynnette W.H. Koh, Yuk Kien Chong, Geraldene R.H. Koh, Jeanne M.M. Tan, Chou Chai, Felicia S.L. Ng, Calvin W.S. Yeo
PDF file - 508K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7d5663fdcdec0d4e5fc3744e2f2dfa
https://doi.org/10.1158/0008-5472.22390464.v1
https://doi.org/10.1158/0008-5472.22390464.v1
Autor:
Lynnette Koh, Wisna Novera, See Wee Lim, Yuk Kien Chong, Qing You Pang, David Low, Beng Ti Ang, Carol Tang
Publikováno v:
Pharmacological research. 182
This review describes recent technological advances applied to glioblastoma (GBM), a brain tumor with dismal prognosis. International consortial efforts suggest the presence of molecular subtypes within histologically identical GBM tumors. This empha
Autor:
Yuk Kien Chong, Edwin Sandanaraj, Beng Ti Ang, Nguan Soon Tan, Wai Hoe Ng, See Wee Lim, Melanie Si Yan Tan, Patrick Tan, Lynnette Koh, Carol Tang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Intratumoral heterogeneity is a hallmark of glioblastoma (GBM) tumors, thought to negatively influence therapeutic outcome. Previous studies showed that mesenchymal tumors have a worse outcome than the proneural subtype. Here we focus on STAT3 as its
Autor:
Shaomeng Wang, Yulun Huang, Ying Xu, Sigal Gery, Ruby Yu-Tong Lin, Tuan Zea Tan, Edwin Sandanaraj, See Wee Lim, John S. Yu, Kassoum Nacro, Moli Huang, Yuk Kien Chong, Anand Mayakonda, Ye Chen, Longchuan Bai, Hiroaki Wakimoto, Xin-Yu Ke, Jianxiang Chen, Liang Xu, Zhengyun Huang, Jeffrey Hill, H. Phillip Koeffler, Carol Tang, Pushkar Dakle, Beng Ti Ang, Lynnette Koh, Markus Müschen, Tseng Tsai Yeo
Publikováno v:
Science Advances
Profiling of active gene-regulatory DNA elements in brain cancer tissues illuminates disease biology and therapeutic targets.
Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylat
Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec6be9888aafd06c8ed01588bb0ced2
https://hdl.handle.net/10356/151048
https://hdl.handle.net/10356/151048
Autor:
Carol Tang, Cheng Lui Daniel Law, Yuk Kien Chong, Beng Ti Ang, Charlie Marvalim, Zhi Yan Jeremy Low, Nguan Soon Tan, Pengcheng Zhu, Hong Sheng Cheng
Publikováno v:
Theranostics
Hypoxic microenvironment is a hallmark of solid tumors, especially glioblastoma. The strong reliance of glioma-propagating cells (GPCs) on hypoxia-induced survival advantages is potentially exploitable for drug development. Methods: To identify key s
Autor:
Elisabetta Dejana, Katharina Hennig, Qingsen Li, Andrea Ghisleni, Tania Dini, Yuk Kien Chong, Michele Crestani, Monica Giannotta, Pascale Monzo, Michael P. Sheetz, Cristina Richichi, Giuliana Pelicci, Nikolaos Kakogiannos, Paolo Maiuri, Beng Ti Ang, Martial Balland, Nils C. Gauthier, Carol Tang
Publikováno v:
Developmental cell. 56(20)
Glioblastoma are heterogeneous tumors composed of highly invasive and highly proliferative clones. Heterogeneity in invasiveness could emerge from discrete biophysical properties linked to specific molecular expression. We identified clones of patien