Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Yujun Hao"'
Autor:
Zhang Lin, Shiyi Yang, Qianqian Qiu, Gaoping Cui, Yanhua Zhang, Meilian Yao, Xiangyu Li, Chengkun Chen, Jun Gu, Ting Wang, Peng Yin, Longci Sun, Yujun Hao
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103286- (2024)
Metabolic reprogramming is a hallmark of human cancer, and cancer-specific metabolism provides opportunities for cancer diagnosis, prognosis, and treatment. However, the underlying mechanisms by which metabolic pathways affect the initiation and prog
Externí odkaz:
https://doaj.org/article/3672e22669e340d2b1995766fb6a0dd8
Publikováno v:
Aerospace, Vol 11, Iss 9, p 755 (2024)
For advanced aircraft, the temperature environment inside the cabin is very severe due to the high flight speed and the compact concentration of the electronic equipment in the cabin. Accurately predicting the temperature environment induced inside t
Externí odkaz:
https://doaj.org/article/0bd6056654624306bcb1658ffaedd87c
Autor:
Ting Wang, Longci Sun, Chengkun Chen, Yingchao Zhang, Baoyu He, Yanhua Zhang, Zhenghe Wang, Hanbing Xue, Yujun Hao
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background PI3K/AKT signaling pathway plays important role in tumorigenesis of human cancer. Protein phosphorylation is crucial for signaling transduction of this pathway. PIK3CA, encoding the catalytic subunit p110α of PI3K complex, is one
Externí odkaz:
https://doaj.org/article/7e2775013f4a4ef3bd9add2c49288dfc
Autor:
Siying Wang, Yangyang Zhou, Ruobing Yu, Jing Ling, Botai Li, Chen Yang, Zhuoan Cheng, Ruolan Qian, Zhang Lin, Chengtao Yu, Jiaojiao Zheng, Xingling Zheng, Qi Jia, Wei Wu, Qiangxin Wu, Mengnuo Chen, Shengxian Yuan, Wei Dong, Yaoping Shi, Robin Jansen, Yujun Hao, Ming Yao, Wenxin Qin, Haojie Jin
Publikováno v:
JHEP Reports, Vol 5, Iss 10, Pp 100843- (2023)
Background & Aims: Exploiting key regulators responsible for hepatocarcinogenesis is of great importance for the prevention and treatment of hepatocellular carcinoma (HCC). However, the key players contributing to hepatocarcinogenesis remain poorly u
Externí odkaz:
https://doaj.org/article/2b9a76a9f8dc434a842fc6f8be8e1f2b
Autor:
Jiayue Lu, Hong Cai, Yujun Hao, Zhang Lin, Shang Liu, Yaping Zhan, Li Ding, Meilan Huang, Zhenyuan Li, Lan Xu, Xiujuan Yan, Li Yang, He Zhang, Wei Zhang, Li Zhao, Junli Zhao, Ting Wang, Leyi Gu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Hemodialysis patients have a high risk of severe/critical COVID-19 and related high mortality, but nirmatrelvir/ritonavir is not recommended for hemodialysis patients with COVID-19 infection because of lack of evidence of safety.Objective
Externí odkaz:
https://doaj.org/article/e84eca5441634495a9817d33f1794fa6
Autor:
Yanhua Zhang, Baoyu He, Dong Zhang, Yifan Zhang, Chengkun Chen, Wenye Zhang, Shiyi Yang, Meilian Yao, Gaoping Cui, Jun Gu, Ting Wang, Zhang Lin, Youben Fan, Zuquan Xiong, Yujun Hao
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112188- (2023)
Summary: PI3K regulatory subunit p85s normally stabilizes and regulates catalytic subunit p110s in the cytoplasm. Recent studies show that p110-free p85s in the nucleus plays important roles in biological processes. However, the mechanisms by which p
Externí odkaz:
https://doaj.org/article/d52e4a4aaa2240ec9875c842368632a0
Publikováno v:
Genes and Diseases, Vol 9, Iss 6, Pp 1391-1393 (2022)
Externí odkaz:
https://doaj.org/article/c45c226648b74f41899c51bff5a0cab5
Autor:
Yujun Hao, Baoyu He, Liping Wu, Yamu Li, Chao Wang, Ting Wang, Longci Sun, Yanhua Zhang, Yangyang Zhan, Yiqing Zhao, Sanford Markowitz, Martina Veigl, Ronald A. Conlon, Zhenghe Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The mechanisms behind the oncogenic role of the PIK3CA helical domain mutant is poorly understood. Here, the authors show that its oncogenic function depends on the release of p85β from mutated p110α, its translocation to the nucleus and the conseq
Externí odkaz:
https://doaj.org/article/87c6c7d00efb4e1c9ad21ebb7b9c170a
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2022)
BackgroundThe past four decades have seen the growing use of tissue or cell transplants in Parkinson’s disease (PD) treatment. Parkinson’s cell therapy is a promising new treatment; however, efficacy of cell transplantation for Parkinson’s dise
Externí odkaz:
https://doaj.org/article/b4e7fa9dd94c4a03a10d3690203dcdf1
Autor:
Ting Wang, Haojie Jin, Jingying Hu, Xi Li, Haoyu Ruan, Huili Xu, Lin Wei, Weihua Dong, Fei Teng, Jianren Gu, Wenxin Qin, Xiaoying Luo, Yujun Hao
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Abstract Background Collagens are the most abundant proteins in extra cellular matrix and important components of tumor microenvironment. Recent studies have showed that aberrant expression of collagens can influence tumor cell behaviors. However, th
Externí odkaz:
https://doaj.org/article/ed138436bf694c419a3b33030f659b7e