Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Yujin, Hoshida"'
Autor:
Atish Mukherji, Frank Jühling, Yogy Simanjuntak, Emilie Crouchet, Fabio Del Zompo, Yuji Teraoka, Alexandre Haller, Philippe Baltzinger, Soumith Paritala, Fahmida Rasha, Naoto Fujiwara, Cloé Gadenne, Nevena Slovic, Marine A. Oudot, Sarah C. Durand, Clara Ponsolles, Catherine Schuster, Xiaodong Zhuang, Jacinta Holmes, Ming-Lun Yeh, Hiromi Abe-Chayama, Mathias Heikenwälder, Angelo Sangiovanni, Massimo Iavarone, Massimo Colombo, Steven K. H. Foung, Jane A. McKeating, Irwin Davidson, Ming-Lung Yu, Raymond T. Chung, Yujin Hoshida, Kazuaki Chayama, Joachim Lupberger, Thomas F. Baumert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Chronic liver disease and cancer are global health challenges. The role of the circadian clock as a regulator of liver physiology and disease is well established in rodents, however, the identity and epigenetic regulation of rhythmically exp
Externí odkaz:
https://doaj.org/article/faee0116ddb14568af297762b93cc7d2
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In in situ capturing-based spatial transcriptomics, spots of the same size and printed at fixed locations cannot precisely capture the randomly-located single cells, therefore inherently failing to profile transcriptome at the single-cell le
Externí odkaz:
https://doaj.org/article/05ac996894544bf4b2709ed745cccfe3
Autor:
Szu-Yu Zoe Kao, Kinpritma Sangha, Naoto Fujiwara, Yujin Hoshida, Neehar D. Parikh, Amit G. Singal
Publikováno v:
EClinicalMedicine, Vol 75, Iss , Pp 102755- (2024)
Summary: Background: Hepatocellular carcinoma (HCC) surveillance is currently performed using a one-size-fits-all strategy with ultrasound plus AFP (US + AFP). There is increasing interest in risk-stratified and precision surveillance strategies inco
Externí odkaz:
https://doaj.org/article/c0e0811210bc4a7695121be427d3ff13
Autor:
David Hsiehchen, Muhammad S. Beg, Radhika Kainthla, Jay Lohrey, Syed M. Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K. Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A. Brekken, Chul Ahn, Amit G. Singal, Hao Zhu, Yujin Hoshida, Adam C. Yopp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Immune checkpoint inhibitors targeting PD-1/L1 have modest efficacy in hepatocellular carcinoma as single agents. Targeting membranous phosphatidylserine may induce pro-inflammatory and -immune stimulating effects that enhance immunotherapy
Externí odkaz:
https://doaj.org/article/742b5357d52e4634b5aea175a59e7fba
Autor:
Kenneth K. Tanabe, David Zahrieh, Carrie A. Strand, Yujin Hoshida, Thomas J. Flotte, Gary Della’Zanna, Asad Umar, Kenneth D. Chavin, Sean Cleary, Naoto Kubota, Josep M. Llovet, Tushar Patel, Christopher Siegel, Paul J. Limburg
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 3, Pp 426-439 (2024)
Background and Aims: Effective approaches for prevention of hepatocellular carcinoma (HCC) will have a significant impact on HCC-related mortality. There are strong preclinical data and rationale to support targeting epidermal growth factor receptor
Externí odkaz:
https://doaj.org/article/b566872f2fe84a5480b71b71604039a4
Autor:
Chiara Rocha, Erin H. Doyle, Chip A. Bowman, M‐Isabel Fiel, Ashley E. Stueck, Nicolas Goossens, Kian Bichoupan, Neal Patel, James F. Crismale, Jasnit Makkar, Sara Lewis, Ponni V. Perumalswami, Thomas D. Schiano, Yujin Hoshida, Myron Schwartz, Andrea D. Branch
Publikováno v:
Cancer Medicine, Vol 12, Iss 9, Pp 10175-10186 (2023)
Abstract Background Successful treatment of hepatitis C reduces liver inflammation and fibrosis; however, patients remain at risk of developing hepatocellular carcinoma (HCC). Aims To identify risk factors for new‐onset HCC in patients cured of hep
Externí odkaz:
https://doaj.org/article/5c53f5a2d4cf4920af975aedc19b8cb0
Autor:
Myung‐Ho Kim, Mi‐Young Kim, Shadi Salloum, Tongqi Qian, Lai Ping Wong, Min Xu, Yoojin Lee, Stuti G. Shroff, Ruslan I. Sadreyev, Kathleen E. Corey, Thomas F. Baumert, Yujin Hoshida, Raymond T. Chung
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2581-2593 (2022)
Abstract Lipophilic but not hydrophilic statins have been shown to be associated with reduced risk for hepatocellular carcinoma (HCC) in patients with chronic viral hepatitis. We investigated differential actions of lipophilic and hydrophilic statins
Externí odkaz:
https://doaj.org/article/40cf497b78c3424da7b5b2059d8f1041
Autor:
Nan Lin, Yongping Lin, Jianfeng Xu, Dan Liu, Diange Li, Hongyu Meng, Maxime A. Gallant, Naoto Kubota, Dhruvajyoti Roy, Jason S. Li, Emmanuel C. Gorospe, Morris Sherman, Robert G. Gish, Ghassan K. Abou‐Alfa, Mindie H. Nguyen, David J. Taggart, Richard A. Van Etten, Yujin Hoshida, Wei Li
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1753-1763 (2022)
Abstract The limited performance of guideline‐recommended abdominal ultrasound and serum alpha‐fetoprotein (AFP) highlights the urgent, unmet need for new biomarkers for more accurate detection of early hepatocellular carcinoma (HCC). To this end
Externí odkaz:
https://doaj.org/article/28c10d8ae2014899a358709c88f612fb
Autor:
Cristina Quintavalle, Nathalie Meyer‐Schaller, Stephanie Roessler, Diego Calabrese, Romina Marone, Tobias Riedl, Silvia Picco‐Rey, Orestis A. Panagiotou, Sarp Uzun, Salvatore Piscuoglio, Tuyana Boldanova, Chaoran B. Bian, David Semela, Wolfram Jochum, Gieri Cathomas, Kirsten D. Mertz, Joachim Diebold, Luca Mazzucchelli, Viktor H. Koelzer, Achim Weber, Thomas Decaens, Luigi M. Terracciano, Mathias Heikenwalder, Yujin Hoshida, Jesper B. Andersen, Snorri S. Thorgeirsson, Matthias S. Matter
Publikováno v:
Hepatology Communications, Vol 6, Iss 6, Pp 1467-1481 (2022)
Chronic liver inflammation causes continuous liver damage with progressive liver fibrosis and cirrhosis, which may eventually lead to hepatocellular carcinoma (HCC). Whereas the 10‐year incidence for HCC in patients with cirrhosis is approximately
Externí odkaz:
https://doaj.org/article/baec932dd7004118b6b3ef62cac7625e
Autor:
Romain Desert, Xiaodong Ge, Zhuolun Song, Hui Han, Daniel Lantvit, Wei Chen, Sukanta Das, Dipti Athavale, Ioana Abraham‐Enachescu, Chuck Blajszczak, Yu Chen, Orlando Musso, Grace Guzman, Yujin Hoshida, Natalia Nieto
Publikováno v:
Hepatology Communications, Vol 6, Iss 4, Pp 692-709 (2022)
Osteopontin (OPN) expression correlates with tumor progression in many cancers, including hepatocellular carcinoma (HCC); however, its role in the onset of HCC remains unclear. We hypothesized that increased hepatocyte‐derived OPN is a driver of he
Externí odkaz:
https://doaj.org/article/21459e8d284541748a8e7d90d829445b