Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Yujiang Geno Shi"'
Autor:
Mandi Mu, Xinze Li, Li Dong, Jin Wang, Qingqing Cai, Yajun Hu, Duanduan Wang, Peng Zhao, Lei Zhang, Daixuan Zhang, Siyi Cheng, Li Tan, Feizhen Wu, Yujiang Geno Shi, Wenqi Xu, Yang Shi, Hongjie Shen
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113116- (2023)
Externí odkaz:
https://doaj.org/article/8e226f0b52f349c694af8319a77a848e
Publikováno v:
Protein & Cell, Vol 11, Iss 4, Pp 304-307 (2019)
Externí odkaz:
https://doaj.org/article/1f3b3814cf1b43bf8ec0f00152e258e2
Autor:
Jiuxing Feng, Shujing Chen, Shuangqi Li, Baitong Wu, Jiacheng Lu, Li Tan, Jiamin Li, Yuanlin Song, Guoming Shi, Yujiang Geno Shi, Jinjun Jiang
Publikováno v:
Translational Oncology, Vol 13, Iss 12, Pp 100865- (2020)
Monocytic myeloid-derived suppressor cells (M-MDSCs), granulocytic MDSC (G-MDSCs) and regulatory T cells (Tregs) inhibit adaptive anti-tumor immunity and undermine the efficacy of anti-PD-1 therapy. However, the impact of anti-PD-1 treatment on these
Externí odkaz:
https://doaj.org/article/ef4e04a403c84fb8a2e8b213fe611712
Publikováno v:
Cancers, Vol 13, Iss 9, p 2207 (2021)
Activation of PD-1/PD-L1 checkpoint is a critical step for the immune evasion of malignant tumors including breast cancer. However, the epigenetic mechanism underlying the aberrant expression of PD-L1 in breast cancer cells remains poorly understood.
Externí odkaz:
https://doaj.org/article/8af7a8f2eaf94d6bb6a372dc69f24153
Autor:
Chun Ma, Violetta Karwacki-Neisius, Haoran Tang, Wenjing Li, Zhennan Shi, Haolin Hu, Wenqi Xu, Zhentian Wang, Lingchun Kong, Ruitu Lv, Zheng Fan, Wenhao Zhou, Pengyuan Yang, Feizhen Wu, Jianbo Diao, Li Tan, Yujiang Geno Shi, Fei Lan, Yang Shi
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 997-1007 (2016)
Nono is a component of the para-speckle, which stores and processes RNA. Mouse embryonic stem cells (mESCs) lack para-speckles, leaving the function of Nono in mESCs unclear. Here, we find that Nono functions as a chromatin regulator cooperating with
Externí odkaz:
https://doaj.org/article/7748b79881e6457c87da8bdf760bfc13
Autor:
Chenxi He, Jing Wen, Honghui Ma, Yang Shi, Yujiang Geno Shi, Jiahui Li, Jiahua Wang, Jianbo Diao, Liyong Wang, Li Tan, Feizhen Wu, Bowen Rong, Hongjie Shen, Wenqi Xu
Publikováno v:
Nature. 591:317-321
METTL3 (methyltransferase-like 3) mediates the N6-methyladenosine (m6A) methylation of mRNA, which affects the stability of mRNA and its translation into protein1. METTL3 also binds chromatin2,3,4, but the role of METTL3 and m6A methylation in chroma
Autor:
Wenjing Li, Feizhen Wu, Li Tan, Yang Shi, Yujiang Geno Shi, Violetta Karwacki-Neisius, Chun Ma
Publikováno v:
Nucleic Acids Research
NONO is a DNA/RNA-binding protein, which plays a critical regulatory role during cell stage transitions of mouse embryonic stem cells (mESCs). However, its function in neuronal lineage commitment and the molecular mechanisms of its action in such pro
Publikováno v:
Biochemical and Biophysical Research Communications. 515:214-221
Small cell lung carcinoma (SCLC) is one of the deadliest cancer types, with a 5-year survival rate less than 10%. Kdm1a/Lsd1 has recently been implicated as a potential therapeutic target for SCLC. However, the underlying molecular mechanism by which
Autor:
Peng-Fei Zhang, Guo-Ming Shi, Qing-Nan Meng, Jian Zhou, Yujiang Geno Shi, Ying-Hao Shen, Xiao-Yong Huang, Jia Fan, Ai-Wu Ke, Ying-Hong Shi, Rui-Zhao Dong, Hui-Chuan Sun, Haiying Zeng, Chao Gao, Jia-Bing Cai, Liu-Xiao Yang, Jia-Cheng Lu, Chuan-Yuan Wei, Xuan Yang, Rui Peng, Qiman Sun
Publikováno v:
Theranostics
Rationale: PD1/PD-L1 immune checkpoint inhibitors have shown promising results for several malignancies. However, PD1/PD-L1 signaling and its therapeutic significance remains largely unknown in intrahepatic cholangiocarcinoma (ICC) cases with complex
Autor:
Wenqi Xu, Chenxi He, Emily G. Kaye, Jiahui Li, Mandi Mu, Geoffrey M. Nelson, Li Dong, Jiahua Wang, Feizhen Wu, Yujiang Geno Shi, Karen Adelman, Fei Lan, Yang Shi, Hongjie Shen
Publikováno v:
Molecular Cell. 82:1156-1168.e7
N6-methyladenosine (m6A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m6A on transcription remains poorly understood. Here, we demonstrate that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) is localized