Inhibitory effects of local anesthetics on the proteasome and their biological actions

Autor: Udin Bahrudin, Masaki Unno, Kazuya Nishio, Akiko Kita, Peili Li, Masaru Kato, Masashi Inoue, Shunichi Tsujitani, Takuto Murakami, Rina Sugiyama, Yasushi Saeki, Yuji Obara, Keiji Tanaka, Hiroshi Yamaguchi, Isao Sakane, Yasushi Kawata, Toshiyuki Itoh, Haruaki Ninomiya, Ichiro Hisatome, Yukio Morimoto

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibi

Externí odkaz: https://doaj.org/article/f5cdc61bc8ea4f0a8fc5652c9651c68c

Inhibitory effects of local anesthetics on the proteasome and their biological actions

Autor: Yasushi Kawata, Isao Sakane, Keiji Tanaka, Peili Li, Hiroshi Yamaguchi, Udin Bahrudin, Yuji Obara, Masaki Unno, Haruaki Ninomiya, Yasushi Saeki, Toshiyuki Itoh, Kazuya Nishio, Ichiro Hisatome, Akiko Kita, Masashi Inoue, Yukio Morimoto, Takuto Murakami, Rina Sugiyama, Shunichi Tsujitani, Masaru Kato

Publikováno v: Scientific Reports
Bahrudin Udin, Unno Masaki, Nishio Kazuya, et al. Inhibitory effects of local anesthetics on the proteasome and their biological actions. SCIENTIFIC REPORTS. 2017. 7. doi:10.1038/s41598-017-04652-2
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibit its act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a2c8283c265689ba74a2b7c2f58965
https://doi.org/10.1038/s41598-017-04652-2

37.1:Invited Paper: Development of Field-Emission Display

Autor: Kyoko Sakurada, Youhei Fujimura, Tatsuo Yamaura, Yasuyuki Takeya, Mamoru Namikawa, Kubo Yasumoto, Masaki Toriumi, Kiyoshi Tamura, Mitsuru Tanaka, Masa Ishibashi, Takeshi Tonegwa, Fumiaki Kataoka, Haruo Kobayashi, Taniguchi Masateru, Kiyoyuki Deguchi, Kenji Nawamaki, Naito Yasuyuki, Takahiro Niiyama, Satoru Kawata, Kazuyoshi Otsu, Yoshitaka Sato, Shigeo Itoh, Yoshihisa Marushima, Yuji Obara

Publikováno v: SID Symposium Digest of Technical Papers. 38:1297-1300

Mono-color Spindt-type Field Emission Displays(FEDs) have been supplied to the market and color FEDs have been started for the preparation of mass production. FEDs have the potential not only to realize superior expression for video picture image, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::868f5d3d42601d993e427bc719fead14
https://doi.org/10.1889/1.2785549

[Untitled]

Autor: Yuji Obara, Mitsuru Tanaka, Shigeo Itoh

Publikováno v: Shinku. 49:23-28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2f8b513d250da8147d90f55d999fefe
https://doi.org/10.3131/jvsj.49.23

Alkaline transition of pseudoazurin Met16X mutant proteins: protein stability influenced by the substitution of Met16 in the second sphere coordination

Autor: Yuji Obara, Takamitsu Kohzuma, Rehab F. Abdelhamid

Publikováno v: Journal of inorganic biochemistry. 102(5-6)

Several blue copper proteins are known to change the active site structure at alkaline pH (alkaline transition). Spectroscopic studies of Met16Phe, Met16Tyr, Met16Trp, and Met16Val pseudoazurin variants were performed to investigate the second sphere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e698cde00708a97a04589aaada59e373
https://pubmed.ncbi.nlm.nih.gov/18343503