Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yuji Morikawa"'
Autor:
Harsh Dweep, Yuji Morikawa, Binsheng Gong, Jian Yan, Zhichao Liu, Tao Chen, Halil Bisgin, Wen Zou, Huixiao Hong, Tieliu Shi, Ping Gong, Christina Castro, Takeki Uehara, Yuping Wang, Weida Tong
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Environmental chemicals exposure is one of the primary factors for liver toxicity and hepatocarcinoma. Thioacetamide (TAA) is a well-known hepatotoxicant and could be a liver carcinogen in humans. The discovery of early and sensitive microRN
Externí odkaz:
https://doaj.org/article/fbe8d2ed9b374448a100bb4a54a29912
Autor:
Sho Kawashima, Yuki Matsui, Takumi Adachi, Yuji Morikawa, Kae Inoue, Shiori Takebayashi, Haruaki Nobori, Masatomo Rokushima, Yuki Tachibana, Teruhisa Kato
Publikováno v:
Biochemical and Biophysical Research Communications. 645:132-136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0903737e4394564589c8f602eedde18
https://doi.org/10.1016/j.bbrc.2023.01.040
https://doi.org/10.1016/j.bbrc.2023.01.040
Autor:
Wei Fan, Yuji Morikawa, Takeshi Higuchi, Yoshihiko Matsui, Tomoe Yamamoto, David Sabens, Brian Kozak
Publikováno v:
MRS Advances. 7:1257-1259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::739e48a92065d3b3bcf520a8949051b4
https://doi.org/10.1557/s43580-022-00406-z
https://doi.org/10.1557/s43580-022-00406-z
Autor:
Rina Sakai1,2 rina.sakai@shionogi.co.jp, Yuji Morikawa1 yuji.morikawa@shionogi.co.jp, Chiaki Kondo1 chiaki.kondou@shionogi.co.jp, Hiroyuki Oka1 hiroyuki.oka@shionogi.co.jp, Hirofumi Miyajima1 hirofumi.miyajima@shionogi.co.jp, Kihei Kubo2 kubokrad@vet.osakafu-u.ac.jp, Takeki Uehara1 takeki.uehara@shionogi.co.jp
Publikováno v:
International Journal of Molecular Sciences. Oct2014, Vol. 15 Issue 10, p17256-17269. 54p. 2 Diagrams, 4 Charts, 2 Graphs.
Autor:
Binsheng Gong, Tieliu Shi, Yuji Morikawa, Tao Chen, Jian Yan, Zhichao Liu, Halil Bisgin, Ping Gong, Weida Tong, Christina J. Castro, Yuping Wang, Harsh Dweep, Takeki Uehara, Wen Zou, Huixiao Hong
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Environmental chemicals exposure is one of the primary factors for liver toxicity and hepatocarcinoma. Thioacetamide (TAA) is a well-known hepatotoxicant and could be a liver carcinogen in humans. The discovery of early and sensitive microRNA (miRNA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f5eecc05d0ab67537126a573373d01
https://doi.org/10.1038/s41598-017-02798-7
https://doi.org/10.1038/s41598-017-02798-7
Autor:
Chiaki Kondo, Kihei Kubo, Hiroyuki Oka, Hirofumi Miyajima, Yuji Morikawa, Takeki Uehara, Rina Sakai
Publikováno v:
International Journal of Molecular Sciences
Volume 15
Issue 10
Pages 17256-17269
International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 17256-17269 (2014)
Volume 15
Issue 10
Pages 17256-17269
International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 17256-17269 (2014)
In vitro mammalian cytogenetic tests detect chromosomal aberrations and are used for testing the genotoxicity of compounds. This study aimed to identify a supportive genomic biomarker could minimize the risk of misjudgments and aid appropriate decisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec194b49e0fe79849a233eecf21a622
https://doi.org/10.3390/ijms151017256
https://doi.org/10.3390/ijms151017256
Autor:
Yuji Morikawa, Mikinori Torii, Takeki Uehara, Keigo Matsuyama, Yuki Kato, Hiroyuki Hanafusa, Yutaka Tonomura, Motonobu Ueno
Publikováno v:
Journal of Applied Toxicology. 35:165-172
Traditional biomarkers such as alanine and aspartate aminotransferase (ALT, AST) and total bilirubin (TBIL) have been widely used for detecting drug-induced liver injury (DILI). Although the Food and Drug Administration (FDA) proposed standardized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19d464ace7a620195467a65bcf63e328
https://doi.org/10.1002/jat.3053
https://doi.org/10.1002/jat.3053
Autor:
Yoko Nishimura, Yutaka Tonomura, Takeki Uehara, Mikinori Torii, Jyoji Yamate, Chiaki Kondo, Yuji Morikawa
Publikováno v:
Journal of Applied Toxicology. 35:173-180
Cardiotoxicity is one of the major safety concerns in drug development. Therefore, detecting and monitoring cardiotoxicity throughout preclinical and clinical studies is important for pharmaceutical companies. The present study was conducted in order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e2035dbac46b064fb6a3a0fa5733d3c
https://doi.org/10.1002/jat.3044
https://doi.org/10.1002/jat.3044
Autor:
Keiichi Minami, Takeki Uehara, Ko Omura, Kunitoshi Mitsumori, Masayuki Kanki, Tetsuro Urushidani, Yuji Morikawa, Hitomi Hayashi, Atsushi Ono, Hiroshi Yamada
Publikováno v:
The Journal of Toxicological Sciences. 39:785-794
We previously reported a toxicogenomics-based prediction model for hepatocarcinogens in which the expression patterns of signature genes following repeated doses of either genotoxic or non genotoxic compounds were similar. Based on the results of our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04f2ba8f864aceed6b02725050658bc
https://doi.org/10.2131/jts.39.785
https://doi.org/10.2131/jts.39.785
Autor:
Keiichi Minami, Hiroshi Yamada, Takeki Uehara, Yuji Morikawa, Yutaka Tonomura, Jyoji Yamate, Tetsuro Urushidani, Atsushi Ono, Akira Horinouchi, Yasuo Ohno
Publikováno v:
Journal of Applied Toxicology. 34:1087-1095
Nephrotoxicity is a common side effect observed during both nonclinical and clinical drug development investigations. The present study aimed to identify metabolomic biomarkers that could provide early and sensitive indication of nephrotoxicity in ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b2169ec9e26af60a899d308243ed45
https://doi.org/10.1002/jat.2933
https://doi.org/10.1002/jat.2933