Výsledky vyhledávání

Development and Validation of a Simple Method for Simultaneously Measuring the Concentrations of BCR-ABL and Bruton Tyrosine Kinase Inhibitors in Dried Blood Spot (DBS): A Pilot Study to Obtain Candidate Conversion Equations for Predicting Plasma Concentration Based on DBS Concentration

Autor: Yuji Mukai, Tatsunari Yoshida, Takeshi Kondo, Jun Miura, Nobuo Inotsume, Takaki Toda

Publikováno v: Therapeutic Drug Monitoring. 44:762-770

Dried blood spots (DBSs) are promising candidates for therapeutic drug monitoring. In this study, a simple method for the simultaneous measurement of tyrosine kinase inhibitors (TKIs), including bosutinib, dasatinib, ibrutinib, imatinib, nilotinib, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b19546b48c041d0e916cfb658a3fb7
https://doi.org/10.1097/ftd.0000000000000997

Zobrazit plný text záznamu

An Liquid Chromatography–Tandem Mass Spectrometry Method for the Simultaneous Determination of Afatinib, Alectinib, Ceritinib, Crizotinib, Dacomitinib, Erlotinib, Gefitinib, and Osimertinib in Human Serum

Autor: Tae Hatsuyama, Takaki Toda, Azusa Wakamoto, Yuji Mukai, Hideki Sato, Tatsunari Yoshida, Akihisa Fujita, Nobuo Inotsume

Publikováno v: Therapeutic Drug Monitoring. 43:772-779

Background Routine therapeutic drug monitoring is a promising approach for the rational use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and anaplastic lymphoma kinase (ALK) inhibitors. The purpose of this study was to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d88c635eb5c82dc8d0b7387b1f0125a
https://doi.org/10.1097/ftd.0000000000000895

Zobrazit plný text záznamu

Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids in patients admitted to a cardiovascular center

Autor: Yuka Kato, Asuna Senda, Yuji Mukai, Miki Yamashita, Yuki Sasaoka, Minayo Hanada, Fuminori Hongo, Mitsugu Hirokami, Anders Rane, Nobuo Inotsume, Takaki Toda

Publikováno v: European Journal of Clinical Pharmacology

Purpose Several clinical studies have demonstrated that angiotensin-converting enzyme inhibitors, but not angiotensin II receptor blockers (ARBs), reduce the risk of non-fatal myocardial infarction and cardiovascular mortality. We found that ARBs inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45e5222de5f97c4a790e23125122525
https://doi.org/10.1007/s00228-020-03061-1

Zobrazit plný text záznamu

Simultaneous Quantification of BCR-ABL and Bruton Tyrosine Kinase Inhibitors in Dried Plasma Spots and Its Application to Clinical Sample Analysis

Autor: Takeshi Kondo, Yuji Mukai, Nobuo Inotsume, Yuka Yoshida, Takaki Toda, Tatsunari Yoshida

Publikováno v: Therapeutic drug monitoring. 43(3)

Background Recent reports highlight the importance of therapeutic drug monitoring (TDM) of BCR-ABL and Bruton's tyrosine kinase inhibitors (TKIs); thus, large-scale studies are needed to determine the target concentrations of these drugs. TDM using d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1355ed138d6d4897af6ecde3f1edc249
https://pubmed.ncbi.nlm.nih.gov/33065614

Zobrazit plný text záznamu

Combined effect of telmisartan and fluvastatin on arachidonic acid metabolism in human liver microsomes

Autor: Anders Rane, Nobuo Inotsume, Yuka Kato, Takaki Toda, Yuji Mukai

Publikováno v: Xenobiotica. 48:898-903

1. Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) via cytochrome P450s, have a protective effect on the cardiovascular system involving vasodilation. We have previously demonstrated that telmisartan (TEL) inhibits EETs product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa35517f21c476604f654aa2d1e98450
https://doi.org/10.1080/00498254.2017.1384079

Zobrazit plný text záznamu

The Inhibitory Effect of Telmisartan on the Metabolism of Arachidonic Acid by CYP2C9 and CYP2C8: An in Vitro Study

Autor: Takaki Toda, Yuji Mukai, Nobuo Inotsume, Yuka Kato, Anders Rane

Publikováno v: Biological & Pharmaceutical Bulletin. 40:1409-1415

Epoxyeicosatorienoic acids (EETs) are generated from arachidonic acid (AA) by CYPs. EETs comprise four regioisomers (14,15-, 11,12-, 8,9-, and 5,6-EET). EETs show potent physiological effects, including vasodilation, anti-inflammation, myocardial pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bee9df8e9a74f2b0ba2c35a0e36c3254
https://doi.org/10.1248/bpb.b17-00174

Zobrazit plný text záznamu

Concentration of Sulfate and Glucuronide Conjugates of Ritodrine in Twin Pregnancy

Autor: Hiroshi Yoshida, Yuji Mukai, Satoko Fujieda, Yoichi Sasaki, Mayuko Soma, Nobuo Inotsume, Ainari Konda, Mitsuaki Keira, Takaki Toda

Publikováno v: Biological & Pharmaceutical Bulletin. 40:922-925

Ritodrine, a drug for the treatment of threatened premature labor, is a highly selective beta-2 agonist with the major metabolites of sulfate and glucuronide conjugates. This study investigated the continuous evaluation of the concentration of ritodr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f205071ff3fcb1e1ec45938874cec745
https://doi.org/10.1248/bpb.b16-00818

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání