Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Yuji Koseki"'
Publikováno v:
International Journal of Mycobacteriology, Vol 6, Iss 1, Pp 61-69 (2017)
Objective/Background: Mycobacterium tuberculosis thymidine monophosphate kinase (mtTMPK) is a potential enzymatic target for the treatment of tuberculosis (TB). Materials and Methods: In this study, we performed pharmacophore-based in silico screenin
Externí odkaz:
https://doaj.org/article/df5b007248d74cd9974058adc8a68550
Autor:
Kosuke Nakashima, Miho Murahashi, Hiroki Yuasa, Mariko Ina, Norihiro Tada, Akichika Itoh, Shin-ichi Hirashima, Yuji Koseki, Tsuyoshi Miura
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 14529-14542 (2013)
Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yie
Externí odkaz:
https://doaj.org/article/78aa70abb5d8477cadc617f80893c625
Autor:
Koichi Machida, Yuji Koseki, Akira Kotani, Kazuhiro Yamamoto, Tsuyoshi Miura, Hideki Hakamata
Publikováno v:
Analytical Methods. 14:4879-4885
A highly sensitive LC-MS/MS method disclosed that deuterium-labeled brassicasterol in serum was increased in a time-dependent manner, when deuterium-labeled ergosterol was orally administrated to stroke-prone spontaneously hypertensive rats.
Autor:
Hiroshi Akutsu, Hikari Matsumoto, Shin-ichi Hirashima, Tsuyoshi Miura, Yuji Koseki, Kosuke Nakashima
Publikováno v:
Tetrahedron. 75:2431-2435
The asymmetric direct bisvinylogous conjugate addition of 5-benzylfurfural derivatives to nitroalkenes using a thiourea organocatalyst resulted in a corresponding e-regioselective addition products in high yields and up to 95% enantiomeric excess.
Autor:
Masahiro Kawada, Kosuke Nakashima, Yuji Koseki, Tsuyoshi Miura, Toru Sakagami, Shin-ichi Hirashima
Publikováno v:
Chirality. 30:1215-1224
In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20 mol% of a novel thiourea-sulfonamide organocatalyst afforded conjugate adducts in moderat
Publikováno v:
Organic Letters. 20:5569-5572
The use of diaminomethylenemalononitrile (DMM) organocatalyst to promote the challenging 1,2-hydrophosphonylation of simple ketones and enones, which are also called α,β-unsaturated ketones, is proposed and validated. This reaction provided the cor
Publikováno v:
The Journal of Organic Chemistry. 83:2402-2408
A diaminomethylenemalononitrile organocatalyst efficiently catalyzed the asymmetric conjugate addition of α-cyanoketones to vinyl ketones to give the corresponding 1,5-dicarbonyl compounds, which bear an all-carbon quaternary stereogenic center with
Autor:
Kosuke Nakashima, Moeko Kitahara, Yuji Koseki, Shin-ichi Hirashima, Hiroshi Akutsu, Tsuyoshi Miura
Publikováno v:
Tetrahedron Letters. 58:4759-4762
A pyrrolidine–diaminomethylenemalononitrile organocatalyst efficiently promotes the asymmetric direct bisvinylogous Michael addition of 5-benzylfurfural derivatives to nitroalkenes, affording the corresponding e-regioselective addition products in
Publikováno v:
Biochemical and Biophysical Research Communications. 490:849-854
2,3-Butandione 2-monoxime (BDM) is a widely used myosin inhibitor with an unclear mode of action. In this report, we investigated the mechanism of BDM oxime group nucleophilic reactivity on the phosphoester bond of ATP. BDM increased the ATPase activ
Autor:
Akihiro Yoshida, Tsuyoshi Miura, Yuji Koseki, Shin-ichi Hirashima, Kosuke Nakashima, Masahiro Kawada
Publikováno v:
The Journal of Organic Chemistry. 82:6986-6991
The asymmetric conjugate addition of nitroalkanes to α,β-unsaturated ketones in the presence of a catalytic amount of a novel sulfonamide-thiourea organocatalyst resulted in the corresponding γ-nitro carbonyl products in high yields with excellent