Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Yuji Ishichi"'
Autor:
Yoshinori Satomi, Nobuyuki Amano, Takafumi Yukawa, Nobuyuki Matsunaga, Tatsuo Oikawa, Kazuki Kubo, Takashi Nakahata, Rei Okamoto, Yasufumi Miyamoto, Yuji Ishichi, Masahiro Kamaura, Satoshi Nishimura, Ryutaro Adachi, Masanori Nakakariya
Publikováno v:
Bioorganicmedicinal chemistry. 28(7)
Sphingomyelin synthase 2 (SMS2) has attracted attention as a drug target for the treatment of various cardiovascular and metabolic diseases. The modification of a high throughput screening hit, 2-quinolone 10, enhanced SMS2 inhibition at nanomolar co
Autor:
Etsuo Kotani, Kazuyoshi Aso, Yohei Kosugi, Mochizuki Michiyo, Takuto Kojima, Takahiko Yano, Maiko Tanaka, Teruaki Okuda, Yuu Sako, Hideyuki Nakagawa, Yuji Ishichi, Naoyuki Kanzaki, Katsumi Kobayashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1556-1570
Compound 1 exhibits potent binding inhibition activity against a corticotropin-releasing factor 1 (CRF1) receptor (IC50=9.5nM) and in vitro antagonistic activity (IC50=88nM) but is rapidly metabolized by human hepatic microsomes (182μL/min/mg). Here
Autor:
Maiko Takiguchi, Hiroyuki Ueno, Yoshihisa Nakada, Masami Yamada, Tomoya Yukawa, Tetsuya Tsukamoto, Hideyuki Nakagawa, Nobuki Sakauchi, Kamei Taku, Ikuo Fujimori, Tomoko Igari, Masako Kuno, Yasushi Fujioka, Izumi Kamo, Yuji Ishichi, Yusuke Ohba
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3716-3726
Peripheral-selective inhibition of noradrenaline reuptake is a novel mechanism for the treatment of stress urinary incontinence to overcome adverse effects associated with central action. Here, we describe our medicinal chemistry approach to discover
Autor:
Eiji Kimura, Naohiro Taya, Katsuaki Oda, Mitsuyoshi Nishitani, Masayuki Yamashita, Toru Yamano, Yuji Ishichi, Jun Terauchi, Tetsuji Kawamoto
Publikováno v:
Tetrahedron: Asymmetry. 26:935-942
The novel triple reuptake inhibitor ( S )-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine monohydrochloride 1 possesses a unique 2-phenyl-2-(piperidin-4-yl)ethanol moiety with a stereogenic center at the benzyl position. To synthesize 1 as the (
Autor:
Hideyuki Nakagawa, Masato Yoshikawa, Eiji Kimura, Yuji Ishichi, Honda Eiji, Jun Terauchi, Yuuichi Arakawa, Hiroyuki Ohta, Atsuko Suzuki, Naoyuki Kanzaki, Takayuki Kawai, Yasuko Terao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3898-3902
A novel series of triple reuptake inhibitors were explored by ligand-based drug design. A cyclic structure was designed from cyclopropane derivative 5 using the core structure of reported monoamine reuptake inhibitors, leading to the formation of the
Autor:
Michiyo, Mochizuki, Takuto, Kojima, Katsumi, Kobayashi, Etsuo, Kotani, Yuji, Ishichi, Naoyuki, Kanzaki, Hideyuki, Nakagawa, Teruaki, Okuda, Yohei, Kosugi, Takahiko, Yano, Yuu, Sako, Maiko, Tanaka, Kazuyoshi, Aso
Publikováno v:
Bioorganicmedicinal chemistry. 25(5)
Compound 1 exhibits potent binding inhibition activity against a corticotropin-releasing factor 1 (CRF
Autor:
Tomoya Yukawa, Ikuo Fujimori, Taku Kamei, Yoshihisa Nakada, Nobuki Sakauchi, Masami Yamada, Yusuke Ohba, Hiroyuki Ueno, Maiko Takiguchi, Masako Kuno, Izumi Kamo, Hideyuki Nakagawa, Yasushi Fujioka, Tomoko Igari, Yuji Ishichi, Tetsuya Tsukamoto
Publikováno v:
Bioorganicmedicinal chemistry. 24(14)
Peripherally selective inhibition of noradrenaline reuptake is a novel mechanism for the treatment of stress urinary incontinence to overcome adverse effects associated with central action. Herein, we describe our medicinal chemistry approach to disc
Autor:
Ikuo Fujimori, Tomoya Yukawa, Taku Kamei, Yoshihisa Nakada, Nobuki Sakauchi, Masami Yamada, Yusuke Ohba, Maiko Takiguchi, Masako Kuno, Izumi Kamo, Hideyuki Nakagawa, Teruki Hamada, Tomoko Igari, Teruaki Okuda, Satoshi Yamamoto, Tetsuya Tsukamoto, Yuji Ishichi, Hiroyuki Ueno
Publikováno v:
Bioorganicmedicinal chemistry. 23(15)
Centrally acting noradrenaline reuptake inhibitor (NRI) is reportedly effective for patients with stress urinary incontinence (SUI) by increasing urethral closure in the clinical Phase IIa study with esreboxetine. Noradrenaline transporters are expre
Publikováno v:
Tetrahedron. 60:4481-4490
A series of novel N-benzylcarboxamide derivatives of bicyclic compounds, 3,4-dihydropyrido[3,2-f][1,4]oxazepin-5(2H)-one and 2,3,4,5-tetrahydro-6H-pyrido[2,3-b][1,5]oxazocin-6-one, were synthesized by cyclization of N-benzyl-2-chloro-N-(2-hydroxyethy
Autor:
Yuji Ishichi, Hiroshi Nagabukuro, Shigemitsu Imai, Yuji Ishihara, Satoshi Okanishi, Takayuki Doi
Publikováno v:
European Journal of Pharmacology. 485:299-305
In the present study, we investigated the effects of 8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802), a novel acetylcholinesterase inhibitor, on distension-induced rhythmic