Zobrazeno 1 - 10
of 618
pro vyhledávání: '"Yuji GOTO"'
Autor:
Kohei Nagao, Tomoko Otsuzumi, Hitomi Chinone, Takashi Sasaki, Junko Yoshimoto, Makiko Matsuda, Souichirou Kubota, Yuji Goto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract In the Japanese hagfish Eptatretus burgeri, 16 chromosomes (eliminated [E]-chromosomes) have been lost in somatic cells (2n = 36), which is equivalent to approx. 21% of the genomic DNA in germ cells (2n = 52). At least seven of the 12 elimin
Externí odkaz:
https://doaj.org/article/eb5213816d874d91a3f9fa1a96c24215
Autor:
Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Amyloid fibrils of β2-microglobulin (β2m) can cause dialysis-related amyloidosis. Here, the authors show that a decrease in serum albumin levels in long-term dialysis deteriorates the inhibitory effects of serum milieux on supersaturation-limited a
Externí odkaz:
https://doaj.org/article/d80ffdffa03b47a68ce0fdd216dda884
Publikováno v:
Biophysics and Physicobiology, Vol 20 (2023)
Much effort has been devoted to elucidate mechanisms of amyloid fibril formation using various kinds of additives, such as salts, metals, detergents, and biopolymers. Here, we review the effects of additives with a focus on polyphosphate (polyP) on a
Externí odkaz:
https://doaj.org/article/f81e8cb0d96243989c1b241efedf3139
Autor:
Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, Kousuke Baba, Seiichi Nagano, Yuji Goto, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Parkinson’s disease is a neurodegenerative disease characterized by the formation of neuronal inclusions of α-synuclein in patient brains. As the disease progresses, toxic α-synuclein aggregates transmit throughout the nervous system. No
Externí odkaz:
https://doaj.org/article/480865b6dc8d4cbda2fe0989319f86ac
Autor:
Kohei Nagao, Yoshiki Tanaka, Rei Kajitani, Atsushi Toyoda, Takehiko Itoh, Souichirou Kubota, Yuji Goto
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0286941 (2023)
In the Japanese hagfish, Eptatretus burgeri, approximately 21% of the genomic DNA in germ cells (2n = 52) consists of 16 chromosomes (eliminated [E]-chromosomes) that are eliminated from presumptive somatic cells (2n = 36). To uncover the eliminated
Externí odkaz:
https://doaj.org/article/2f111a10ccd9491fbc70f7056c3b1c85
Autor:
Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, Hideki Mochizuki, József Kardos, Daniel E. Otzen, Vittorio Bellotti, Johannes Buchner, Yuji Goto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Noji et al. test link between protein folding and misfolding upon heating and agitation. They show that folding and amyloid formation are separated by the supersaturation barrier of a protein, breakdown of which shifts the protein to the amyloid path
Externí odkaz:
https://doaj.org/article/ed4d8eeda119466189e820b1da445527
Autor:
Koki Furukawa, Cesar Aguirre, Masatomo So, Kenji Sasahara, Yohei Miyanoiri, Kazumasa Sakurai, Keiichi Yamaguchi, Kensuke Ikenaka, Hideki Mochizuki, Jozsef Kardos, Yasushi Kawata, Yuji Goto
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 35-44 (2020)
Proteins in either a native or denatured conformation often aggregate at an isoelectric point (pI), a phenomenon known as pI precipitation. However, only a few studies have addressed the role of pI precipitation in amyloid formation, the crystal-like
Externí odkaz:
https://doaj.org/article/a67334422dc445e68557bcef82563693
Autor:
Yi Zhang, Konosuke Otomaru, Kazunaga Oshima, Yuji Goto, Ichiro Oshima, Susumu Muroya, Mitsue Sano, Sanggun Roh, Takafumi Gotoh
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
We hypothesized that maternal low or high nutrition would give unique effects to morphological and molecular dynamics in adipose tissue of fetus of fatty breed Wagyu (Japanese Black) cattle which produce highly marbled beef. This study aimed to deter
Externí odkaz:
https://doaj.org/article/12a6411833454160b6ad36af2d47505c
Publikováno v:
Molecules, Vol 27, Iss 14, p 4588 (2022)
The supersaturation of a solution refers to a non-equilibrium phase in which the solution is trapped in a soluble state, even though the solute’s concentration is greater than its thermodynamic solubility. Upon breaking supersaturation, crystals fo
Externí odkaz:
https://doaj.org/article/9e513c6f7a014eb89f0e384634bd9735
Autor:
Yuki Yoshikawa, Keisuke Yuzu, Naoki Yamamoto, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Tetsushi Iwasaki, Masatomo So, Yuji Goto, Atsuo Tamura, Eri Chatani
Publikováno v:
Molecules, Vol 27, Iss 13, p 3964 (2022)
Amyloid fibrils have been an important subject as they are involved in the development of many amyloidoses and neurodegenerative diseases. The formation of amyloid fibrils is typically initiated by nucleation, whereas its exact mechanisms are largely
Externí odkaz:
https://doaj.org/article/38b66ab5c6674483a5ad5271480a0da0