Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yuichiro Nakaishi"'
Autor:
Emiliano Tamanini, Shin Miyamura, Ildiko M. Buck, Benjamin D. Cons, Lee Dawson, Charlotte East, Takashi Futamura, Shintaro Goto, Charlotte Griffiths-Jones, Tetsuya Hashimoto, Tom D. Heightman, Shunpei Ishikawa, Hideki Ito, Yosuke Kaneko, Tatsuya Kawato, Kazumi Kondo, Naoki Kurihara, James M. McCarthy, Yukiko Mori, Tsuyoshi Nagase, Yuichiro Nakaishi, Judith Reeks, Akimasa Sato, Patrick Schöpf, Kuninori Tai, Taichi Tamai, Dominic Tisi, Alison J.-A. Woolford
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1591-1597
Fragment-based ligand discovery was successfully applied to histone deacetylase HDAC2. In addition to the anticipated hydroxamic acid- and benzamide-based fragment screening hits, a low affinity (∼1 mM) α-amino-amide zinc binding fragment was iden
Autor:
Thale C. Jarvis, Yuichi Ishikawa, Yuichiro Nakaishi, Thomas E. Edwards, Nebojsa Janjic, Chi Zhang, John C. Rohloff, Douglas R. Davies, Jeffrey D. Carter, Shashi Kumar Gupta, Masao Hirota, Amy D. Gelinas
Publikováno v:
The Journal of Biological Chemistry
Background: Traditional aptamers favor polar interactions with protein binding partners. Results: The IL-6·SOMAmer structure reveals an interface rich in hydrophobic interactions that overlap the binding sites of IL-6 receptors. Conclusion: Hydropho
Autor:
Hideaki Tsuge, Goto Fumitaka, Kazumi Kondo, Kenji Watanabe, Yuichiro Nakaishi, Masahiko Bando, Hiroshi Shimizu, Makoto Komatsu
Publikováno v:
FEBS Letters. 583:163-167
Glutamine:fructose-6-phosphate amidotransferase (GFAT) is a rate-limiting enzyme in the hexoamine biosynthetic pathway and plays an important role in type 2 diabetes. We now report the first structures of the isomerase domain of the human GFAT in the
Autor:
Naoyuki Miyazaki, Yuichiro Nakaishi, Khoon Tee Chong, Mamoru Suzuki, Kazunori Namba, Fusamichi Akita, Hideaki Tanaka, Tomitake Tsukihara, Eiki Yamashita, Yasuko Ono, Atsushi Nakagawa
Publikováno v:
Journal of Molecular Biology. 368:1469-1483
Pyrococcus furiosus is a hyperthermophilic archaeal microorganism found near deep-sea thermal vents and its optimal growth temperature of 100 degrees C. Recently, a 38.8-kDa protein from P. furiosus DSM 3638 was isolated and characterized. Electron m
Autor:
Tomitake Tsukihara, Mamoru Suzuki, Fusamichi Akita, K. Nanba, Eiki Yamashita, Naoyuki Miyazaki, Atsushi Nakagawa, Hideaki Tanaka, C.K. Tee, Yuichiro Nakaishi, Y. Ono
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 61:c235-c235
Autor:
Daniel J. Schneider, Steven K. Wolk, Thale C. Jarvis, Chi Zhang, Shashi Kumar Gupta, Nebojsa Janjic, Akira Nagabukuro, Thomas E. Edwards, Alex B. Burgin, Wesley S. Mayfield, Akihiko Hisaminato, Lance Stewart, Takashi Wadatsu, Haretsugu Hishigaki, Bharat Gawande, Sheela Waugh, Amy D. Gelinas, Daniel I. Resnicow, Yuichiro Nakaishi, Douglas R. Davies
Publikováno v:
Structure. (7):1293-1304
SummaryDiscerning the structural building blocks of macromolecules is essential for understanding their folding and function. For a new generation of modified nucleic acid ligands (called slow off-rate modified aptamers or SOMAmers), we previously ob
Autor:
Gelinas, Amy D.1, Davies, Douglas R.2, Edwards, Thomas E.2, Rohloff, John C.1, Carter, Jeffrey D.1, Chi Zhang1, Shashi Gupta1, Yuichi Ishikawa3, Masao Hirota3, Yuichiro Nakaishi3, Jarvis, Thale C.1, Nebojsa Janjic1 njanjic@somalogic.com
Publikováno v:
Journal of Biological Chemistry. 3/21/2014, Vol. 289 Issue 12, p8720-8734. 15p.