Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yuichiro Nakaishi"'
Autor:
Emiliano Tamanini, Shin Miyamura, Ildiko M. Buck, Benjamin D. Cons, Lee Dawson, Charlotte East, Takashi Futamura, Shintaro Goto, Charlotte Griffiths-Jones, Tetsuya Hashimoto, Tom D. Heightman, Shunpei Ishikawa, Hideki Ito, Yosuke Kaneko, Tatsuya Kawato, Kazumi Kondo, Naoki Kurihara, James M. McCarthy, Yukiko Mori, Tsuyoshi Nagase, Yuichiro Nakaishi, Judith Reeks, Akimasa Sato, Patrick Schöpf, Kuninori Tai, Taichi Tamai, Dominic Tisi, Alison J.-A. Woolford
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1591-1597
Fragment-based ligand discovery was successfully applied to histone deacetylase HDAC2. In addition to the anticipated hydroxamic acid- and benzamide-based fragment screening hits, a low affinity (∼1 mM) α-amino-amide zinc binding fragment was iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a51f121f3406b6de752dce46b777833
https://doi.org/10.1021/acsmedchemlett.2c00272
https://doi.org/10.1021/acsmedchemlett.2c00272
Autor:
Thale C. Jarvis, Yuichi Ishikawa, Yuichiro Nakaishi, Thomas E. Edwards, Nebojsa Janjic, Chi Zhang, John C. Rohloff, Douglas R. Davies, Jeffrey D. Carter, Shashi Kumar Gupta, Masao Hirota, Amy D. Gelinas
Publikováno v:
The Journal of Biological Chemistry
Background: Traditional aptamers favor polar interactions with protein binding partners. Results: The IL-6·SOMAmer structure reveals an interface rich in hydrophobic interactions that overlap the binding sites of IL-6 receptors. Conclusion: Hydropho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cc870b97c9cf3ca9e218cd101ea0ca
https://doi.org/10.1074/jbc.m113.532697
https://doi.org/10.1074/jbc.m113.532697
Autor:
Hideaki Tsuge, Goto Fumitaka, Kazumi Kondo, Kenji Watanabe, Yuichiro Nakaishi, Masahiko Bando, Hiroshi Shimizu, Makoto Komatsu
Publikováno v:
FEBS Letters. 583:163-167
Glutamine:fructose-6-phosphate amidotransferase (GFAT) is a rate-limiting enzyme in the hexoamine biosynthetic pathway and plays an important role in type 2 diabetes. We now report the first structures of the isomerase domain of the human GFAT in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cf7a493e259191a4421ad13b98d0bd
https://doi.org/10.1016/j.febslet.2008.11.041
https://doi.org/10.1016/j.febslet.2008.11.041
Autor:
Naoyuki Miyazaki, Yuichiro Nakaishi, Khoon Tee Chong, Mamoru Suzuki, Kazunori Namba, Fusamichi Akita, Hideaki Tanaka, Tomitake Tsukihara, Eiki Yamashita, Yasuko Ono, Atsushi Nakagawa
Publikováno v:
Journal of Molecular Biology. 368:1469-1483
Pyrococcus furiosus is a hyperthermophilic archaeal microorganism found near deep-sea thermal vents and its optimal growth temperature of 100 degrees C. Recently, a 38.8-kDa protein from P. furiosus DSM 3638 was isolated and characterized. Electron m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a14fbe43e7dcf496a0c78a13cd3f192
https://doi.org/10.1016/j.jmb.2007.02.075
https://doi.org/10.1016/j.jmb.2007.02.075
Autor:
Tomitake Tsukihara, Mamoru Suzuki, Fusamichi Akita, K. Nanba, Eiki Yamashita, Naoyuki Miyazaki, Atsushi Nakagawa, Hideaki Tanaka, C.K. Tee, Yuichiro Nakaishi, Y. Ono
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 61:c235-c235
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82aa4508390b40db7c7e4183847f4f7c
https://doi.org/10.1107/s010876730508997x
https://doi.org/10.1107/s010876730508997x
Autor:
Daniel J. Schneider, Steven K. Wolk, Thale C. Jarvis, Chi Zhang, Shashi Kumar Gupta, Nebojsa Janjic, Akira Nagabukuro, Thomas E. Edwards, Alex B. Burgin, Wesley S. Mayfield, Akihiko Hisaminato, Lance Stewart, Takashi Wadatsu, Haretsugu Hishigaki, Bharat Gawande, Sheela Waugh, Amy D. Gelinas, Daniel I. Resnicow, Yuichiro Nakaishi, Douglas R. Davies
Publikováno v:
Structure. (7):1293-1304
SummaryDiscerning the structural building blocks of macromolecules is essential for understanding their folding and function. For a new generation of modified nucleic acid ligands (called slow off-rate modified aptamers or SOMAmers), we previously ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a477e0b3779b33cb1fa25f01164ef8b
Publikováno v:
Journal of Membrane Biology; Jun2023, Vol. 256 Issue 3, p229-241, 13p
Autor:
Gelinas, Amy D.1, Davies, Douglas R.2, Edwards, Thomas E.2, Rohloff, John C.1, Carter, Jeffrey D.1, Chi Zhang1, Shashi Gupta1, Yuichi Ishikawa3, Masao Hirota3, Yuichiro Nakaishi3, Jarvis, Thale C.1, Nebojsa Janjic1 njanjic@somalogic.com
Publikováno v:
Journal of Biological Chemistry. 3/21/2014, Vol. 289 Issue 12, p8720-8734. 15p.