Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Yuichiro, Hirayama"'
Autor:
Masanobu Kawanishi, Chiaki Shimohara, Yoshimitsu Oda, Yuuta Hisatomi, Yuta Tsunematsu, Michio Sato, Yuichiro Hirayama, Noriyuki Miyoshi, Yuji Iwashita, Yuko Yoshikawa, Haruhiko Sugimura, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Takashi Yagi, Kenji Watanabe
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-6 (2020)
Abstract Introduction Colibactin is a small genotoxic molecule produced by enteric bacteria, including certain Escherichia coli (E. coli) strains harbored in the human large intestine. This polyketide-peptide genotoxin is considered to contribute to
Externí odkaz:
https://doaj.org/article/6496a12ac1ae42c187cc8a997a882d99
Autor:
Shinji Kishimoto, Kodai Hara, Hiroshi Hashimoto, Yuichiro Hirayama, Pier Alexandre Champagne, Kendall N. Houk, Yi Tang, Kenji Watanabe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds v
Externí odkaz:
https://doaj.org/article/e314b137eb8e447180aa93d7b1b86b62
Publikováno v:
Biochemistry. 61:2782-2790
Recent studies have shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2606e0da4644239ee6b0e975530ec5
https://doi.org/10.1021/acs.biochem.2c00229
https://doi.org/10.1021/acs.biochem.2c00229
Autor:
Yuichiro HIRAYAMA, Kenji WATANABE
Publikováno v:
KAGAKU TO SEIBUTSU. 60:123-130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3714407987fa546675619f6b06e9e04f
https://doi.org/10.1271/kagakutoseibutsu.60.123
https://doi.org/10.1271/kagakutoseibutsu.60.123
Autor:
Yuji Iwashita, Nahoko Uchiyama, Noriyuki Miyoshi, Seiji Tanaka, Michio Sato, Hideki Ishikawa, Haruhiko Sugimura, Tao Zhou, Yuichiro Hirayama, Kenji Watanabe, Nanami Suzuki, Yukihiro Goda, Yuta Tsunematsu, Michihiro Mutoh, Yuko Yoshikawa, Keiji Wakabayashi
Publikováno v:
Journal of the American Chemical Society. 143:5526-5533
Colibactin is a polyketide-nonribosomal peptide hybrid secondary metabolite that can form interstrand cross-links in double-stranded DNA. Colibactin-producing Escherichia coli has also been linked to colorectal oncogenesis. Thus, there is a strong in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d885120780f7226479d0b1513dd8004
https://doi.org/10.1021/jacs.1c01495
https://doi.org/10.1021/jacs.1c01495
Autor:
Fumi Higashiguchi, Hideki Ishikawa, Yuji Iwashita, Haruhiko Sugimura, Yuichiro Hirayama, Kenji Watanabe, Noriyuki Miyoshi, Nobuo Matsuzaki, Michihiro Mutoh, Yuta Tsunematsu, Keiji Wakabayashi, Yuko Yoshikawa, Michio Sato
Publikováno v:
Japanese Journal of Infectious Diseases. 73:437-442
We investigated the relationship between colibactin-producing (clb+) Escherichia coli and colorectal adenocarcinoma. In total, 729 E. coli colonies were isolated from tumor and surrounding non-tumor regions in resected specimens from 34 Japanese pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7636c4b00cc65b2c38dbe1c3d3b87dbc
https://doi.org/10.7883/yoken.jjid.2020.066
https://doi.org/10.7883/yoken.jjid.2020.066
Autor:
Keiji Wakabayashi, Yukari Totsuka, Yuichiro Hirayama, Kumiko Ogawa, Takeji Takamura-Enya, Takeshi Toyoda, Kohei Matsushita, Yuya Tajima, Takanori Yamada, Kenji Watanabe, Noriyuki Miyoshi
Publikováno v:
Chemical Research in Toxicology. 33:1907-1914
o-Toluidine (o-Tol), a monocyclic aromatic amine, causes bladder cancer in humans and experimental animals and is therefore classified as a Group 1 carcinogen (IARC) in which the carcinogenicity of o-Tol is involved in metabolic activation, DNA damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c14f2c5ed33aa36dfd1f32411101331b
https://doi.org/10.1021/acs.chemrestox.0c00098
https://doi.org/10.1021/acs.chemrestox.0c00098
Autor:
Nobuo Matsuzaki, Fumihiko Tanioka, Yuji Iwashita, Michio Sato, Yuta Tsunematsu, Ryota Tamafune, Kenji Watanabe, Michihiro Mutoh, Yuichiro Hirayama, Hideki Ishikawa, Keiji Wakabayashi, Noriyuki Miyoshi, Haruhiko Sugimura, Ippei Ohnishi, Yuko Yoshikawa
Publikováno v:
Organic Letters. 21:4490-4494
While high-colibactin-producing Escherichia coli is thought to be associated with colorectal oncogenesis, this study is complicated part due to an inability to isolate colibactin adequately. Here, we created fluorescent probes activated by ClbP, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd63b1eb57b27ed0af96e0341f87302
https://doi.org/10.1021/acs.orglett.9b01345
https://doi.org/10.1021/acs.orglett.9b01345
Autor:
Takahiro Masuya, Michio Sato, Yuta Tsunematsu, Kenji Watanabe, Yuichiro Hirayama, Hiroshi Noguchi, Takehito Nakazawa
Publikováno v:
Organic & Biomolecular Chemistry. 17:234-239
Use of the ku70-deficient strain of Coprinopsis cinerea enabled confirmation within the native context of the central role the sesquiterpene synthase Cop6 plays in lagopodin biosynthesis. Furthermore, yeast in vivo bioconversion and in vitro assays o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2262f2c637c1ed6b2e641096d90fd9
https://doi.org/10.1039/c8ob02814a
https://doi.org/10.1039/c8ob02814a
Autor:
Takashi Yagi, Yoshimitsu Oda, Michio Sato, Yuuta Hisatomi, Yuta Tsunematsu, Yuko Yoshikawa, Haruhiko Sugimura, Yuichiro Hirayama, Chiaki Shimohara, Yuji Iwashita, Kenji Watanabe, Michihiro Mutoh, Keiji Wakabayashi, Hideki Ishikawa, Masanobu Kawanishi, Noriyuki Miyoshi
Publikováno v:
The Journal of Toxicological Sciences. 44:871-876
Colibactin is a polyketide-peptide genotoxin produced by enteric bacteria such as E. coli, and is considered to contribute to the development of colorectal cancer. We previously isolated E. coli strains from Japanese colorectal cancer patients, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0f5c371796efece3627c794623d0952
https://doi.org/10.2131/jts.44.871
https://doi.org/10.2131/jts.44.871