Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Yuichiro, Hara"'
Autor:
Okiru Komine, Syuhei Ohnuma, Kunihiko Hinohara, Yuichiro Hara, Mayuko Shimada, Tomohiro Akashi, Seiji Watanabe, Akira Sobue, Noe Kawade, Tomoo Ogi, Koji Yamanaka
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108872- (2024)
Summary: Recent single-cell analyses have revealed the complexity of microglial heterogeneity in brain development, aging, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Disease-associated microglia (DAMs) have been ident
Externí odkaz:
https://doaj.org/article/d7f739989e174708a15aabfdf39bff50
Autor:
Ayuka Murakami, Seiya Noda, Tomoyuki Kazuta, Satoko Hirano, Seigo Kimura, Hirotaka Nakanishi, Koji Matsuo, Koyo Tsujikawa, Madoka Iida, Haruki Koike, Kazuma Sakamoto, Yuichiro Hara, Satoshi Kuru, Kenji Kadomatsu, Teppei Shimamura, Tomoo Ogi, Masahisa Katsuno
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 10, Pp 1602-1615 (2022)
Abstract Objective Sporadic inclusion body myositis (sIBM) is the most common acquired myopathy in patients older than 50 years of age. sIBM is hardly responds to any immunosuppressing theraphies, and its pathophysiology remains elusive. This study a
Externí odkaz:
https://doaj.org/article/3b07e9ffabbe43e98c89603134aaff9c
Autor:
Naoya Yamaguchi, Atsushi Suzuki, Aya Yoshida, Tatsushi Tanaka, Kohei Aoyama, Hisashi Oishi, Yuichiro Hara, Tomoo Ogi, Izuki Amano, Satomi Kameo, Noriyuki Koibuchi, Yasuhiro Shibata, Shinya Ugawa, Haruo Mizuno, Shinji Saitoh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract SLC26A4 is a known iodide transporter, and is localized at the apical membrane of thyrocytes. Previously, we reported that SLC26A7 is also involved in iodide transport and that Slc26a7 is a novel causative gene for congenital hypothyroidism.
Externí odkaz:
https://doaj.org/article/e96f5e5bc5174803af6db215698f5947
Autor:
Yuichiro Hara, Shigehiro Kuraku
Publikováno v:
eLife, Vol 12 (2023)
Functionally indispensable genes are likely to be retained and otherwise to be lost during evolution. This evolutionary fate of a gene can also be affected by factors independent of gene dispensability, including the mutability of genomic positions,
Externí odkaz:
https://doaj.org/article/5b28620b64f24f25b1075db1c69087bf
Autor:
Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C. Saido, Naruhiko Sahara, Makoto Higuchi, Tomoo Ogi, Koji Yamanaka
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Microglia-mediated neuroinflammation has been implicated in the pathogenesis of Alzheimer’s disease (AD). Although microglia in aging and neurodegenerative disease model mice show a loss of homeostatic phenotype and activation of disease-a
Externí odkaz:
https://doaj.org/article/f0f701e9e83d46abbb0f133d94d230a5
Publikováno v:
Open Biology, Vol 11, Iss 7 (2021)
Trehalose is a versatile non-reducing sugar. In some animal groups possessing its intrinsic production machinery, it is used as a potent protectant against environmental stresses, as well as blood sugar. However, the trehalose biosynthesis genes rema
Externí odkaz:
https://doaj.org/article/e9da4dcb719940c182a8e61adee9de24
Autor:
Yuichiro Hara, Miki Takeuchi, Yuka Kageyama, Kaori Tatsumi, Masahiko Hibi, Hiroshi Kiyonari, Shigehiro Kuraku
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-19 (2018)
Abstract Background Conventionally, comparison among amniotes – birds, mammals, and reptiles – has often been approached through analyses of mammals and, for comparison, birds. However, birds are morphologically and physiologically derived and, m
Externí odkaz:
https://doaj.org/article/f0dd76e243a34d6aabbaf210dceca332
Autor:
Mitsutaka Kadota, Yuichiro Hara, Kaori Tanaka, Wataru Takagi, Chiharu Tanegashima, Osamu Nishimura, Shigehiro Kuraku
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The nuclear protein CCCTC-binding factor (CTCF) contributes as an insulator to chromatin organization in animal genomes. Currently, our knowledge of its binding property is confined mainly to mammals. In this study, we identified CTCF homolo
Externí odkaz:
https://doaj.org/article/000f1e4311804be694fb69c2ada280e4
Autor:
Yuichiro Hara, Takuma Kumamoto, Naoko Yoshizawa-Sugata, Kumiko Hirai, Song Xianghe, Hideya Kawaji, Chiaki Ohtaka-Maruyama
During the development of the mammalian cerebral cortex, numerous neurons are arranged in a six-layer structure with an inside-out fashion to form the neocortex and wire neural circuits. This process includes cell proliferation, differentiation, migr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa669c8d653f01da1a9a140aecf6b663
https://doi.org/10.1101/2023.04.12.536360
https://doi.org/10.1101/2023.04.12.536360
Autor:
Takuma Hashimoto, Daiki D. Horikawa, Yuki Saito, Hirokazu Kuwahara, Hiroko Kozuka-Hata, Tadasu Shin-I, Yohei Minakuchi, Kazuko Ohishi, Ayuko Motoyama, Tomoyuki Aizu, Atsushi Enomoto, Koyuki Kondo, Sae Tanaka, Yuichiro Hara, Shigeyuki Koshikawa, Hiroshi Sagara, Toru Miura, Shin-ichi Yokobori, Kiyoshi Miyagawa, Yutaka Suzuki, Takeo Kubo, Masaaki Oyama, Yuji Kohara, Asao Fujiyama, Kazuharu Arakawa, Toshiaki Katayama, Atsushi Toyoda, Takekazu Kunieda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Tardigrades are resistant to extreme environmental conditions including dehydration, radiation and the vacuum of space. Here the authors present a high-quality genome which displays minimal horizontal gene transfer, and identify the unique tardigrade
Externí odkaz:
https://doaj.org/article/29c031cfa4904104a798649f99ba60cf