Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Yuichi Sekine"'
Autor:
Yuichi Sekine, Kazuna Kikkawa, Sachie Honda, Yuto Sasaki, Shoya Kawahara, Akihiro Mizushima, Sumihito Togi, Masahiro Fujimuro, Kenji Oritani, Tadashi Matsuda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Signal-transducing adaptor protein-2 (STAP-2) is an adaptor molecule involved in several cellular signaling cascades. Here, we attempted to identify novel STAP-2 interacting molecules, and identified c-Cbl associated protein (CAP) as a bindi
Externí odkaz:
https://doaj.org/article/7bf27e00d121436392bc0ef217fb1824
Autor:
Yuto Sasaki, Shoya Kawahara, Yuichi Sekine, Jun-Ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda
Publikováno v:
Exploration of Immunology, Vol 3, Iss 6, Pp 604-612 (2023)
Adaptor proteins are involved in various immune responses via the modulation of many signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains typical domains such as the pleckstrin homology (PH) domain, Sr
Externí odkaz:
https://doaj.org/article/439caa0b65ef491788b1062cff2a7f16
Autor:
Tadashi Matsuda, Yuto Sasaki, Kota Kagohashi, Kodai Saitoh, Yuichi Sekine, Jun-Ichi Kashiwakura, Kenji Oritani
Publikováno v:
Exploration of Immunology, Vol 2, Iss 6, Pp 771-782 (2022)
Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades. Signal-transducing
Externí odkaz:
https://doaj.org/article/0b3fcf02991c4d808df3b30d876d89c7
Autor:
Maria Teresa Dell’Anno, Xingxing Wang, Marco Onorati, Mingfeng Li, Francesca Talpo, Yuichi Sekine, Shaojie Ma, Fuchen Liu, William B. J. Cafferty, Nenad Sestan, Stephen M. Strittmatter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The optimal type or regional origin of stem cells for regenerative applications in the nervous system has not yet been established. Here the authors show that human neuroepithelial stem cells from the developing spinal cord, but not those from the de
Externí odkaz:
https://doaj.org/article/0c6bf4dc8dc74542a0664aa648168a87
Autor:
Yuichi Sekine, Alexander Lin-Moore, Devon M. Chenette, Xingxing Wang, Zhaoxin Jiang, William B. Cafferty, Marc Hammarlund, Stephen M. Strittmatter
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 415-428 (2018)
Summary: Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult mammals. We used a genome-wide loss-of-function screen for factors limiting axonal regeneration from cerebral cortical neurons in vitro. Knockdown of
Externí odkaz:
https://doaj.org/article/5c89e73ff23d433f812eaf32552d8352
Publikováno v:
Microorganisms, Vol 9, Iss 6, p 1169 (2021)
Kaposi’s sarcoma-associated herpesvirus (KSHV) causes Kaposi’s sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman disease. Although capsid formation and maturation in the alpha-herpesvirus herpes simplex virus 1 are well underst
Externí odkaz:
https://doaj.org/article/37b5d7b27c5448c891479316164e9746
Publikováno v:
Viruses, Vol 12, Iss 12, p 1391 (2020)
Herpes simplex virus-1 (HSV-1) is the causative agent of cold sores, keratitis, meningitis, and encephalitis. HSV-1-encoded ICP5, the major capsid protein, is essential for capsid assembly during viral replication. Ubiquitination is a post-translatio
Externí odkaz:
https://doaj.org/article/55ef9385e0b24e949a5f0f95211fa2c6
Autor:
Alexandra B Byrne, Rebecca D McWhirter, Yuichi Sekine, Stephen M Strittmatter, David M Miller III, Marc Hammarlund
Publikováno v:
eLife, Vol 5 (2016)
The ability of a neuron to regenerate its axon after injury depends in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose) poly
Externí odkaz:
https://doaj.org/article/b7f2b81c9905458f8d36ba102e5a8f23
Publikováno v:
Materials Transactions; 2024, Vol. 65 Issue 8, p977-986, 10p
Autor:
Kodai Saitoh, Jun-ichi Kashiwakura, Kota Kagohashi, Yuto Sasaki, Shoya Kawahara, Yuichi Sekine, Yuichi Kitai, Ryuta Muromoto, Michiko Ichii, Hiroko Nakatsukasa, Akihiko Yoshimura, Kenji Oritani, Tadashi Matsuda
Publikováno v:
The Journal of Immunology. 209:57-68
TCR ligation with an Ag presented on MHC molecules promotes T cell activation, leading to the selection, differentiation, and proliferation of T cells and cytokine production. These immunological events are optimally arranged to provide appropriate r