Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yuichi Oshida"'
Autor:
Masanobu Yoshioka, Shigeyuki Chaki, Yoshihisa Toda, Yuichi Oshida, Kaori Hamamoto, Yoshiaki Yamano, Isao Morishima
Publikováno v:
Journal of Veterinary Medical Science. 66:1323-1327
We investigated the effects of electrical foot shock stress on the melanocortin signaling cascade and the hypothalamus-pituitary-adrenal (HPA) system by observing levels of mRNA expression of corticotropin releasing factor (CRF), pro-opiomelanocortin
Autor:
Kazuyuki Tomisawa, Yuichi Oshida, Shigeyuki Chaki, Toshihito Kumagai, Yuko Hamajima, Atsuro Nakazato, Taketoshi Okubo, Yoko Ikeda, Shigeru Okuyama
Publikováno v:
European Journal of Pharmacology. 371:205-211
We investigated pharmacological properties of CRA1000 (2-(N-(2-methylthio-4-isopropylphenyl)-N-ethylamino-4-(4-(3-fluorophenyl)-1,2,3,6-tetrahydropyridin-1-yl)-6-methylpyrimidine) and CRA1001 (2-(N-(2-bromo-4-isopropylphenyl)-N-ethylamino-4-(4-(3-flu
Autor:
Yoshihisa Toda, Yuichi Oshida, Yoshiaki Yamano, Rio Kamon, Isao Morishima, Takao Yoshimizu, Masanobu Yoshioka, Shigeyuki Chaki
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 68:1369-1371
We constructed several mutant human MC4R cDNAs by site directed mutagenesis and expressed these receptors in COS-1 cells. The conserved DRY motif among GPCRs was mutated to generate eight mutants. While no MC4R ligand binding was detected in any of t
Autor:
Taketoshi Okubo, Takeo Funakoshi, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato, Toshiharu Shimazaki, Shin-ichi Ogawa, Yuichi Oshida
Publikováno v:
Pharmacology, biochemistry, and behavior. 82(4)
In the present study, we examined the anxiolytic and antidepressant effects of MCL0042, a novel compound showing activity in both MC4 receptor antagonism and serotonin transporter inhibition. MCL0042 showed relatively high affinity for the MC4 recept
Publikováno v:
Life sciences. 74(15)
The full-length complementary DNA (cDNA) of monkey corticotropin-releasing factor type 1 (CRF1) receptor was isolated from a rhesus monkey (Macaca mulatta) amygdala cDNA library. The cloned monkey CRF1 receptor cDNA has 2,374 bp with an open reading
Autor:
Yoko Ikeda, Yuichi Oshida, Shigeyuki Chaki, Tadashi Inagami, Shigeru Okuyama, Chiyo Shiota, Ichiro Miyata
Publikováno v:
Biochemical and biophysical research communications. 256(3)
We have identified and characterized a cDNA encoding a novel isoform of the corticotropin-releasing factor (CRF) receptor, referred to as CRF2alpha-tr, from the rat amygdala cDNA library. The nucleotide sequence of the cloned cDNA has a structure of
Publikováno v:
Journal of bioscience and bioengineering. 88(3)
The complementary DNA (cDNA) and chromosomal DNA encoding the citrate synthase (EC 4.1.3.7) gene (cit1) of Aspergillus niger WU-2223L, a citric acid-producing strain, were cloned. Synthetic oligonucleotide primers were designed according to the amino
Publikováno v:
Japanese Journal of Pharmacology. 79:238