Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Yuichi Ohwaki"'
1
Evaluation for effect of hypothermia on the disposition of 4-nitrophenol in rats by in-vitro metabolism study and rat liver perfusion system
Autor: Hirotaka Miyamoto, Yuichi Ohwaki, Satoshi Matsueda, Shintaro Fumoto, Kenta Shimokawa, Kotaro Komori, Mikiro Nakashima, Naoki Yoshikawa, Koyo Nishida, Haruna Hirata
Publikováno v: Journal of Pharmacy and Pharmacology. 65:1536-1540
Objectives The aim of this study was to evaluate the effect of hypothermia on the in-vivo pharmacokinetics of 4-nitrophenol (4NP) using rat liver homogenate and rat liver perfusion system. Methods Rat liver homogenate was incubated with 4NP, which is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6743f128122bcf130957ba7bafdb86f
https://doi.org/10.1111/jphp.12130
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2
Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system†
Autor: Junzo Nakamura, Koyo Nishida, Hirotaka Miyamoto, Yuichi Ohwaki, Hitoshi Sasaki, Haruna Hirata, Hideaki Miyake, Shintaro Fumoto, Naoki Yoshikawa
Publikováno v: Journal of Pharmacy and Pharmacology. 64:848-854
Objectives The aim of this study was to determine the factor changing the hepatic disposition of a drug during hypothermia using a rat liver perfusion system. Methods The livers of male Wistar rats were perfused at 37, 32 or 28°C in the single-pass
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5804433c66805a48917d447d8fcdb81
https://doi.org/10.1111/j.2042-7158.2012.01478.x
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3
Influence of calcium channel blockers in patients with gastrointestinal disease in Japanese community pharmacies
Autor: C. Miyazaki, A. Hamada, T. Hamada, Kenichiro Nakashima, J. Ishii, R. Akiyoshi, Yuichi Ohwaki, Mitsuhiro Wada, N. Hamada, Rie Ikeda
Publikováno v: Journal of Clinical Pharmacy and Therapeutics. 37:74-77
Summary What is known and Objective: Calcium channel blockers (CCBs), which have been widely used for the treatment of hypertension and angina pectoris, decrease lower oesophageal sphincter pressure and, as a result, can exacerbate gastrointestinal d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b887330c684da458b59ca9d1b3d1bf98
https://doi.org/10.1111/j.1365-2710.2011.01253.x
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4
Study on Use of Antisecretory Drugs following Treatment with Calcium Channel Blockers among Non-elderly Patients in Community Pharmacies
Autor: Mitsuhiro Wada, Akihiro Hamada, Kenichiro Nakashima, Choichiro Miyazaki, Yuichi Ohwaki, Rie Ikeda, Ryuji Akiyoshi, Noriko Hamada, Tetsuya Hamada, Jun Ishii
Publikováno v: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 37:203-208
Calcium channel blockers (CCBs) decrease lower esophageal sphincter pressure,which may result in gastrointestinal disease.In a previous study,we observed an increased risk of gastrointestinal disease following treatment with CCBs in elderly patients.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de8dfc9cc4c0ea38f7c812b2ae421c1a
https://doi.org/10.5649/jjphcs.37.203
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5
Increased risk of exacerbating gastrointestinal disease among elderly patients following treatment with calcium channel blockers
Autor: N. Hamada, J. Ishii, Yuichi Ohwaki, T. Hamada, A. Hamada, Mitsuhiro Wada, Kenichiro Nakashima, C. Miyazaki, K. Doi
Publikováno v: Journal of Clinical Pharmacy and Therapeutics. 33:619-624
Summary Background and objective: Calcium channel blockers (CCBs) have been widely used for the treatment of hypertension and angina pectoris. It is presumed that CCBs decrease the lower esophageal sphincter pressure and as a result, the risk of gast
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0518d5b4d9d7fc79531caa4eba0535ac
https://doi.org/10.1111/j.1365-2710.2008.00958.x
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6
Interaction study of aspirin or clopidogrel on pharmacokinetics of donepezil hydrochloride in rats by HPLC-fluorescence detection
Autor: Yuichi Ohwaki, Tomoko Yamane, Junichiro Nishiwaki, Mitsuhiro Wada, Kenichiro Nakashima, Hassan Y. Aboul-Enein
Publikováno v: Biomedical Chromatography. 21:616-620
The present study aims to investigate the possibility of interaction of aspirin (Asp) or clopidogrel (CG) on donepezil (DP) hydrochloride in rats by HPLC-fluorescence detection. The separation of DP was achieved in ca. 13 min without interference of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42376c28549f8dc7b9fa34e8b09fe1f
https://doi.org/10.1002/bmc.794
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8
Semi-micro column high-performance liquid chromatography with UV detection for quantification of aspirin and salicylic acid and its application to patients' sera administered with low-dose enteric-coated aspirin
Autor: Takashi Ishimatsu, Yuichi Ohwaki, Mitsuhiro Wada, Kenichiro Nakashima, Tomoko Yamane
Publikováno v: Biomedical chromatography : BMC. 21(3)
A simultaneous determination of aspirin (ASA) and its metabolite, salicylic acid (SA), in human serum by a semi-micro column HPLC-UV was developed. A relatively small size of serum sample (100 microL) containing ASA and SA was cleaned up by a simple
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679eea89e47cda0041086bec11024abf
https://pubmed.ncbi.nlm.nih.gov/17221906
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