Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yuichi Mishima"'
Autor:
Ryota Mizushima, Ju Yaen Kim, Isao Suetake, Hiroaki Tanaka, Tomoyo Takai, Narutoshi Kamiya, Yu Takano, Yuichi Mishima, Shoji Tajima, Yuji Goto, Kenji Fukui, Young-Ho Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98554 (2014)
MutL is a multi-domain protein comprising an N-terminal ATPase domain (NTD) and C-terminal dimerization domain (CTD), connected with flexible linker regions, that plays a key role in DNA mismatch repair. To expand understanding of the regulation mech
Externí odkaz:
https://doaj.org/article/aca89f16ab304fe4bed2c0498c10bed4
Autor:
Junji Otani, Hironobu Kimura, Jafar Sharif, Takaho A Endo, Yuichi Mishima, Toru Kawakami, Haruhiko Koseki, Masahiro Shirakawa, Isao Suetake, Shoji Tajima
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82961 (2013)
Hydroxymethylcytosine in the genome is reported to be an intermediate of demethylation. In the present study, we demonstrated that maintenance methyltransferase Dnmt1 scarcely catalyzed hemi-hydroxymethylated DNA and that the hemi-hydroxymethylated D
Externí odkaz:
https://doaj.org/article/ef986fcf7d7a4be3be0499679d302662
Autor:
Isao Suetake, Kazunobu Sato, Tomoaki Sugishita, Yuichi Mishima, Toshiki Takei, Toshimichi Fujiwara, Risa Mutoh, Akira Shinohara, Takeji Takui, Makoto Miyata, Hironobu Hojo, Toshiaki Arata
Publikováno v:
Applied Magnetic Resonance. 54:119-141
Publikováno v:
hamon. 32:33-37
Autor:
Shigeaki Nakazawa, Kazunobu Sato, Isao Suetake, Norio Sakai, Toshiaki Arata, Takeji Takui, Toshiki Takei, Yuichi Mishima, Mikio Watanabe, Makoto Miyata, Hironobu Hojo, Toshimichi Fujiwara, Toru Kawakami, Risa Mutoh, Akira Shinohara
Publikováno v:
Biochemical and biophysical research communications. 567
The structural dynamics of the chromo-shadow domain (CSD) and chromodomain (CD) of human HP1 proteins essential for heterochromatin formation were investigated at the nanosecond and nanometer scales by site-directed spin labeling electron paramagneti
Publikováno v:
Biophysical Journal. 114:2336-2351
Heterochromatin protein 1 (HP1), associated with heterochromatin formation, recognizes an epigenetically repressive marker, trimethylated lysine 9 in histone H3 (H3K9me3), and generally contributes to long-term silencing. How HP1 induces heterochroma
Autor:
Kyohei Arita, J. Otani, Toru Kawakami, Masahiro Shirakawa, Yuichi Mishima, Laura Brueckner, Akira Shinohara, Hironobu Hojo, Saori Takahashi, Isao Suetake, Shota Oka, Mikio Watanabe
Publikováno v:
FEBS Journal. 284(20):3455-3469
DNA methylation in promoter regions represses gene expression and is copied over mitotic divisions by Dnmt1. Dnmt1 activity is regulated by its replication foci targeting sequence (RFTS) domain which masks the catalytic pocket. It has been shown that
Publikováno v:
Journal of Peptide Science. 23:532-538
Post-translational modifications of histone proteins, which form nucleosome cores, play an important role in gene regulation. Ubiquitin modification is one such modification. We previously reported on the use of a thiirane linker to introduce a 1,2-a
Chemical synthesis of the ubiquitinated form of histone H3 and its effect on DNA methyltransferase 1
Publikováno v:
Journal of Peptide Science. 25
Posttranslational modifications of histone proteins, which form nucleosome cores, play an important role in gene regulation. Ubiquitination is one such modification. We previously reported on the synthesis of ubiquitinated histone H3 with an isopepti
Autor:
Mikio Watanabe, Hideyuki Takeshima, Kyohei Arita, Toru Kawakami, Makoto Nakanishi, Yuichi Mishima, Kohei Takeshita, Laura Brueckner, Akira Shinohara, J. Otani, Charlotte Nachtegael, Norio Sakai, Hironobu Hojo, Kinichi Nakashima, Saori Takahashi, Isao Suetake, Atsuya Nishiyama, Ronald Garingalao Garvilles
Publikováno v:
Genes to cells
Genes to cells, 25
Genes to cells, 25
DNA methylation controls gene expression, and once established, DNA methylation patterns are faithfully copied during DNA replication by the maintenance DNA methyltransferase Dnmt1. In vivo, Dnmt1 interacts with Uhrf1, which recognizes hemimethylated