Výsledky vyhledávání - "Yuichi Kawanishi"

Akademický článek

Tumor cell enrichment by tissue suspension improves sensitivity to copy number variation in diffuse gastric cancer with low tumor content

Autor: Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Hiroyuki Ichida, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Sumiko Ohnami, Shumpei Ohnami, Koji Maruyama, Akane Naruoka, Hirotsugu Kenmotsu, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract The detection of copy number variations (CNVs) and somatic mutations in cancer is important for the selection of specific drugs for patients with cancer. In cancers with sporadic tumor cells, low tumor content prevents the accurate detection

Externí odkaz: https://doaj.org/article/3803f9f730f74fb287285c07c11200a5

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Akademický článek

Tumor cell enrichment by tissue suspension enables detection of mutations with low variant allele frequency and estimation of germline mutations

Autor: Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Hirotsugu Kenmotsu, Tohru Mochizuki, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)

Abstract Targeted sequencing offers an opportunity to select specific drugs for cancer patients based on alterations in their genome. However, accurate sequencing cannot be performed in cancers harboring diffuse tumor cells because of low tumor conte

Externí odkaz: https://doaj.org/article/6695e80cba474b6392ca70861efa1b00

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Akademický článek

Soft coral Sarcophyton (Cnidaria: Anthozoa: Octocorallia) species diversity and chemotypes.

Autor: Satoe Aratake, Tomohiko Tomura, Seikoh Saitoh, Ryouma Yokokura, Yuichi Kawanishi, Ryuichi Shinjo, James Davis Reimer, Junichi Tanaka, Hideaki Maekawa

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30410 (2012)

Research on the soft coral genus Sarcophyton extends over a wide range of fields, including marine natural products and the isolation of a number of cembranoid diterpenes. However, it is still unknown how soft corals produce this diverse array of met

Externí odkaz: https://doaj.org/article/3b339e14956b4178b788c7460f02243b

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Tumor cell enrichment by tissue suspension enables detection of mutations with low variant allele frequency and estimation of germline mutations

Publikováno v: Scientific reports. 12(1)

Targeted sequencing offers an opportunity to select specific drugs for cancer patients based on alterations in their genome. However, accurate sequencing cannot be performed in cancers harboring diffuse tumor cells because of low tumor content. We pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc51c85fae32d5474a826d6df7d7997
https://pubmed.ncbi.nlm.nih.gov/35194076

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Defective repair capacity of variant proteins of the DNA glycosylase NTHL1 for 5-hydroxyuracil, an oxidation product of cytosine

Autor: Hisami Kato, Hong Tao, Masanori Goto, Yuichi Kawanishi, Katsuhiro Yoshimura, Satoki Nakamura, Haruhiko Sugimura, Kazuya Shinmura, Kiyoshi Misawa

Publikováno v: Free Radical Biology and Medicine. 131:264-273

The NTHL1 gene encodes DNA glycosylase, which is involved in base excision repair, and biallelic mutations of this gene result in NTHL1-associated polyposis (NAP), a hereditary disease characterized by colorectal polyposis and multiple types of carci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b553ada233cb66563bbf925147161d3
https://doi.org/10.1016/j.freeradbiomed.2018.12.010

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Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation

Autor: Hisami Kato, Kazuhito Funai, Hideya Kawasaki, Kimihide Kusafuka, Hiroyuki Mineta, Haruhiko Sugimura, Kazuo Tsuchiya, Takahiko Hariyama, Kiyoshi Misawa, Kazuya Shinmura, Yuichi Kawanishi

Publikováno v: The Journal of pathologyReferences. 254(5)

Primary cilia (PC) are non-motile, antenna-like structures on the cell surface. Many types of neoplasms exhibit PC loss, whereas in some neoplasms PC are retained and involved in tumourigenesis. To elucidate the PC status and characteristics of major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce9ec0dc8d79bca6e59156255d8ba15
https://pubmed.ncbi.nlm.nih.gov/33931860

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Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma

Autor: Yusuke Inoue, Hong Tao, Hisaki Igarashi, Haruhiko Sugimura, Masanori Goto, Hiroshi Furuse, Kazuya Shinmura, Yuichi Kawanishi, Kimio Yoshimura, Hisami Kato, Seiichiro Ozono, Takayuki Sugiyama

Publikováno v: Molecular Carcinogenesis. 56:781-788

8-Hydroxyguanine (8OHG), a major oxidative DNA lesion, is known to accumulate in prostate cancer; however, the status of one of its repair enzymes, MUTYH, in prostate cancer remains to be elucidated. In this study, we showed that the expression level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85fe8c7065bbe1f39261c5d34797ed50
https://doi.org/10.1002/mc.22509

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SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer

Autor: Kiyotaka Kurachi, Hisami Kato, Takaharu Kamo, Chunping Du, Toshio Nakamura, Kiyoko Nagura, Yusuke Okubo, Yusuke Inoue, Yuichi Kawanishi, Kazuya Shinmura, Nobuya Kurabe, Moriya Iwaizumi, Haruhiko Sugimura

Publikováno v: Oncology Reports. 34:727-738

Spindle assembly abnormal protein 6 homolog (SASS6) plays an important role in the regulation of centriole duplication. To date, the genetic alteration of SASS6 has not been reported in human cancers. In the present study, we examined whether SASS6 e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cf64b8fa994ce4f638ca9a994c917d
https://doi.org/10.3892/or.2015.4014

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A novel cluster of mariner-like elements belonging to mellifera subfamily from spiders and insects: implications of recent horizontal transfer on the South-West Islands of Japan

Autor: Raj Deep Gurung, Takeshi Sasaki, Akinori Yamada, Yuichi Kawanishi, Yumiko Nakajima, Kaori Yamada, Hideaki Maekawa, Gaku Tokuda

Publikováno v: Genetica. 142:149-160

Mariner-like elements (MLEs) have been isolated from various eukaryotic genomes and they are divided into 15 subfamilies, including main five subfamilies: mauritiana, cecropia, mellifera/capitata, irritans, and elegans/briggsae. In the present study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2ca0ab0c602533b993b9574706d930
https://doi.org/10.1007/s10709-014-9762-9

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