Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yuichi Aiba"'
Autor:
Kohei Kometani, Masaki Nakahara, Shinji Sakamoto, Yoshihiro Watanabe, Soichi Sano, Yoshiteru Sasaki, Shigeo Murata, Kazuhiro Iwai, Tomohiro Kurosaki, Yuichi Aiba, Keiji Tanaka
Publikováno v:
The EMBO Journal. 32:2463-2476
The linear ubiquitin chain assembly complex (LUBAC) plays a crucial role in activating the canonical NF-κB pathway, which is important for B-cell development and function. Here, we describe a mouse model (B-HOIP(Δlinear)) in which the linear polyub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414403ab1f4955bd621e53061b2fd7fa
https://doi.org/10.1038/emboj.2013.184
https://doi.org/10.1038/emboj.2013.184
Publikováno v:
Immunological Reviews. 237:104-116
Memory antibody responses are typically seen to T-cell-dependent antigens and are characterized by the rapid production of high titers of high-affinity antigen-specific antibody. The hallmark of T-cell-dependent memory B cells is their expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8f5ebfc16af81b6a3588d3b4b0b6f0
https://doi.org/10.1111/j.1600-065x.2010.00939.x
https://doi.org/10.1111/j.1600-065x.2010.00939.x
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
Publikováno v:
Blood. 111:1497-1503
Despite the importance of phosphoinositide 3-kinase (PI3K) in B-cell development, its activation mechanism still remains elusive. In this study, we show that deletion of both BCAP and CD19 leads to an almost complete block of BCR-mediated Akt activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04eae8db913fa05bae32b1a21a252d29
https://doi.org/10.1182/blood-2007-08-109769
https://doi.org/10.1182/blood-2007-08-109769
Autor:
Takanori Kanai, Taeko Dohi, Koji Uraushihara, Yuichi Aiba, Mamoru Watanabe, Motomi Yamazaki, Tetsuya Higuchi, Ryoichi Iiyama, Tetsuya Nakamura, Teruji Totsuka, Takeshi Tsubata, Takahiro Kawamura, Chikara Taneda
Publikováno v:
The Journal of Immunology. 172:6388-6397
Several studies indicate that CD4+ T cells, macrophages, and dendritic cells initially mediate intestinal inflammation in murine models of human inflammatory bowel disease. However, the initial role of B cells in the development of intestinal inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cce677dfdd1ea4c913c44a4a0220c9
https://doi.org/10.4049/jimmunol.172.10.6388
https://doi.org/10.4049/jimmunol.172.10.6388
Differentiation in Culture of Murine Primitive Lymphohematopoietic Progenitors Toward T-Cell Lineage
Publikováno v:
Blood. 93:4187-4195
Earlier, we described a stromal cell-free two-step clonal culture system in which murine primitive lymphohematopoietic progenitors produce myeloid and B-lymphoid lineage cells. In the same culture T-cell potential of the progenitors was maintained. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01635628a8ae79b3ac82a63bf9d77c76
https://doi.org/10.1182/blood.v93.12.4187
https://doi.org/10.1182/blood.v93.12.4187
Autor:
Yuichi Aiba, Makio Ogawa
Publikováno v:
Blood. 90:3923-3930
We have recently established a clonal culture system that supports the growth of immature natural killer (NK) cells from murine fetal thymocytes. We now describe a culture system for mixed NK cell colony formation from single lymphohematopoietic prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280e76470a7df06641e40914186210af
https://doi.org/10.1182/blood.v90.10.3923
https://doi.org/10.1182/blood.v90.10.3923
Publikováno v:
Blood. 89:4005-4012
We have established a clonal cell culture system that supports the proliferation of committed natural killer (NK) cell progenitors of mice to investigate the pathway and cytokine regulation of NK cell development. Day 14 fetal thymocytes cultured in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc2b18cadc70ddfc6d9a5d3f1902802
https://doi.org/10.1182/blood.v89.11.4005
https://doi.org/10.1182/blood.v89.11.4005
Publikováno v:
Cellular Immunology. 177:18-25
We compared the T cell generation from progenitors (T-progenitors) in the fetal liver (FL) with those in the fetal thymus (FT) and adult bone marrow (BM) by culturing these T-progenitors with hematopoietic cell-depleted FT lobes. As has previously be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33a74136a813393029583716598765f
https://doi.org/10.1006/cimm.1997.1094
https://doi.org/10.1006/cimm.1997.1094
Publikováno v:
Mechanisms of Ageing and Development. 87:99-114
The changes in the T cell repertoire of aging BALB/c mice include an increase of V beta 8 + T cells, most of which have a relatively low density of T cell receptors (TCR). We investigated the response of V beta 8 + T cells to staphylococcal enterotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1ece50633448c7d71505e065fe76fa
https://doi.org/10.1016/0047-6374(96)01700-9
https://doi.org/10.1016/0047-6374(96)01700-9
Publikováno v:
International Immunology. 6:1475-1483
The role of antigen presenting cells (APC) in T cell clonal deletion was investigated by culturing murine thymic lymphocytes with the superantigen staphylococcal enterotoxin B (SEB) in the absence or presence of APC. As the APC, we used B lymphoma ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf4634b31a6c62ac04510bbe616a89c
https://doi.org/10.1093/intimm/6.10.1475
https://doi.org/10.1093/intimm/6.10.1475