Výsledky vyhledávání - "Yuichi, Kawai"

Akademický článek

The Cellular Accumulation of Vehicle Exhaust Particulates Changes the Acidic pH Environment of Lysosomes in BEAS-2B Airway Epithelial Cells

Autor: Akira Onodera, Takuya Shimomura, Hirohisa Ochi, Ryuto Sunada, Eiko Fukutomi, Koushi Hidaka, Yuichi Kawai

Publikováno v: Journal of Xenobiotics, Vol 13, Iss 4, Pp 653-661 (2023)

Many people are exposed every day to vehicle exhaust particulates (VEPs), which are thought to be taken up by epithelial cells that are the first barrier in our biological defense. The study aim was to investigate how VEPs are processed in the lysoso

Externí odkaz: https://doaj.org/article/de948f71ba6648e3b0bdfc5b826aa5db

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Akademický článek

Exploring the dynamics of snoring in relation to sleep stages: Implications for gender differences, sleep position, and upper airway collapsibility.

Autor: Masaaki Suzuki, Yuichi Kawai, Yoshihiro Funayama

Publikováno v: PLoS ONE, Vol 19, Iss 1, p e0295232 (2024)

ObjectiveThe purpose of this study was to determine the sleep stage during which isolated snoring occurs in children and adults, and to analyze changes after treatment of obstructive sleep apnea (OSA).MethodsThis retrospective study examined duration

Externí odkaz: https://doaj.org/article/ab627a37eb214a73a57782c1070a0b3e

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Akademický článek

Nanosized Particles of Synthetic Silicon Dioxide Delay the Regeneration of Gastric Ulcers Created by N-Methyl-N′-Nitro-N-Nitrosoguanidine and Induce Hyper-Trophic Gastritis-like Symptoms

Autor: Ayaka Iwasaki, Yuichi Kawai, Akira Onodera

Publikováno v: Scientia Pharmaceutica, Vol 92, Iss 2, p 20 (2024)

Synthetically produced silicon dioxide used as a food additive exhibits nanoparticle size and shape during the early stages of manufacturing. Even when processed into food products, these nanoparticles are detected. Although processing food ingredien

Externí odkaz: https://doaj.org/article/c52c8f7a35644e21a1d495585105f660

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Akademický článek

Reduction of calcium flux from the extracellular region and endoplasmic reticulum by amorphous nano-silica particles owing to carboxy group addition on their surface

Autor: Akira Onodera, Katsutoshi Yayama, Hideto Morosawa, Yukina Ishii, Yasuo Tsutsumi, Yuichi Kawai

Publikováno v: Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 330-334 (2017)

Several studies have reported that amorphous nano-silica particles (nano-SPs) modulate calcium flux, although the mechanism remains incompletely understood. We thus analyzed the relationship between calcium flux and particle surface properties and de

Externí odkaz: https://doaj.org/article/288232343d5c4930a53807507f92e503

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Data from TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models

Autor: Kenichi Matsuo, Shuichi Ohkubo, Renu Wadhwa, Tadashi Shimamura, Yuichi Kawai, Hikari Araki, Kaoru Funabashi, Kenji Tanaka, Hirokazu Ohsawa, Akihiro Hashimoto, Akio Fujioka, Kei Oguchi, Yayoi Fujioka, Kimihiro Ito, Hiroki Irie

Activated HER2 is a promising therapeutic target for various cancers. Although several reports have described HER2 inhibitors in development, no covalent-binding inhibitor selective for HER2 has been reported. Here, we report a novel compound TAS0728

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9557f3e6055579f404ae14fec7e4b96
https://doi.org/10.1158/1535-7163.c.6538552.v1

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Table S2 from TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models

The list of 68 non-kinase targets tested in a panel of binding assays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7624fa0550e00d5951c0a9c8cc00196e
https://doi.org/10.1158/1535-7163.22507003.v1

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Figure S1 from TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models

Synthetic procedures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c90416375724ad01f5f7465a51ff06
https://doi.org/10.1158/1535-7163.22507012.v1

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Akademický článek

Short-term changes in intracellular ROS localisation after the silver nanoparticles exposure depending on particle size

Autor: Akira Onodera, Fumiko Nishiumi, Kisa Kakiguchi, Atsushi Tanaka, Nami Tanabe, Aki Honma, Katsutoshi Yayama, Yasuo Yoshioka, Kumiko Nakahira, Shigenobu Yonemura, Itaru Yanagihara, Yasuo Tsutsumi, Yuichi Kawai

Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 574-579 (2015)

Silver nanoparticles (AgNPs) induce the production of reactive oxygen species (ROS) and apoptosis. These effects are enhanced by smaller particles. Using live-cell imaging, we show that AgNPs induced ROS production rapidly in a size-dependent manner

Externí odkaz: https://doaj.org/article/96aaab99cd97479f8e38e248c4e4ed13

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