Výsledky vyhledávání - "Yuichi, Deguchi"

Akademický článek

Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

Autor: Daiki Nakatsuka, Takaya Izumi, Tasuku Tsukamoto, Miki Oyama, Kohei Nishitomi, Yuichi Deguchi, Kazuki Niidome, Hidekuni Yamakawa, Hisanori Ito, Koichi Ogawa

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

Disease-modifying therapies, such as neuroprotective and neurorestorative interventions, are strongly desired for Alzheimer’s disease (AD) treatment. Several studies have suggested that histone deacetylase 2 (HDAC2) inhibition can exhibit disease-m

Externí odkaz: https://doaj.org/article/c841b9aef81c4ced98bd22dc7a9a7458

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Akademický článek

A Novel RNA Synthesis Inhibitor, STK160830, Has Negligible DNA-Intercalating Activity for Triggering A p53 Response, and Can Inhibit p53-Dependent Apoptosis

Autor: Akinori Morita, Shintaro Ochi, Hidetoshi Satoh, Shohei Ujita, Yosuke Matsushita, Kasumi Tada, Mihiro Toyoda, Yuichi Nishiyama, Kosuke Mizuno, Yuichi Deguchi, Keiji Suzuki, Yoshimasa Tanaka, Hiroshi Ueda, Toshiya Inaba, Yoshio Hosoi, Shin Aoki

Publikováno v: Life, Vol 11, Iss 10, p 1087 (2021)

RNA synthesis inhibitors and protein synthesis inhibitors are useful for investigating whether biological events with unknown mechanisms require transcription or translation; however, the dependence of RNA synthesis has been difficult to verify becau

Externí odkaz: https://doaj.org/article/226b2bd169514384b437e7a610d97e22

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Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

Autor: Kohei Nishitomi, Tasuku Tsukamoto, Hidekuni Yamakawa, Koichi Ogawa, Daiki Nakatsuka, Miki Oyama, Yuichi Deguchi, Kazuki Niidome, Hisanori Ito, Takaya Izumi

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7949412d45e68d79040b636cebed40f0
https://www.frontiersin.org/articles/10.3389/fnmol.2021.782375/full

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Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors

Autor: Hidetoshi, Satoh, Shintaro, Ochi, Kosuke, Mizuno, Yutaka, Saga, Shohei, Ujita, Miyu, Toyoda, Yuichi, Nishiyama, Kasumi, Tada, Yosuke, Matsushita, Yuichi, Deguchi, Keiji, Suzuki, Yoshimasa, Tanaka, Hiroshi, Ueda, Toshiya, Inaba, Yoshio, Hosoi, Akinori, Morita, Shin, Aoki

Publikováno v: Bioorganic & Medicinal Chemistry. 67:116764

It is known that p53 is an important transcription factor and plays a central role in ionizing radiation (IR)-induced DNA damage responses such as cell cycle arrest, DNA repair and apoptosis. We previously reported that regulating p53 protein is an e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60de33587073ab523c8e9631db1d878
https://doi.org/10.1016/j.bmc.2022.116764

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Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice

Autor: Atsubumi Ogawa, Shuh Narumiya, Yuichi Deguchi, Ryota Shinohara, Yoan Cherasse, Michael Lazarus, Aliza T. Ehrlich, Siho Kitaoka, Akira Sawa, Kentarou Yokogawa, Masayuki Taniguchi, Tomoyuki Furuyashiki, Yoshihiro Urade

Publikováno v: Molecular Psychiatry. 23(8):1717-1730

Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the dysfunction of prefrontal dopamine has been associated with cognitive and emotional deficits in mental illnesses. These findings have led to clinical trials o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16aca66706cea8e4d44d2d4864789625
https://hdl.handle.net/20.500.14094/90005770

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mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety

Autor: Yoan Cherasse, Ryota Shinohara, Masaya Harada, Daisuke Yamada, Yuichi Deguchi, Shuh Narumiya, Michael Lazarus, Dai Watanabe, Tomoyuki Furuyashiki, Masayuki Sekiguchi, Yoshihiro Urade

Publikováno v: Cell Reports. 17(9):2405-2417

Here, we show neuronal inactivation-induced presynaptic remodeling and involvement of the mammalian homolog of Diaphanous (mDia) and Rho-associated coiled-coil-containing kinase (ROCK), Rho-regulated modulators of actin and myosin, in this process. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abe4cfca2ac9e9e69f10a5c01869740
https://tsukuba.repo.nii.ac.jp/records/40189

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Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis

Autor: Yuichi Deguchi, Keizo Takao, Hiroshi Ueda, Tsuyoshi Miyakawa, Keita Sasaki, Atsushi Tajima, Sebok Kumar Halder

Publikováno v: Journal of neurochemistry. 141(1)

Prothymosin alpha (ProTα) is expressed in various mammalian organs including the neuronal nuclei in the brain, and is involved in multiple functions, such as chromatin remodeling, transcriptional regulation, cell proliferation, and survival. ProTα

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9ae4f9471b4040b6f3dc32e5d9d8f1
https://pubmed.ncbi.nlm.nih.gov/28122138

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Temporally matched subpopulations of selectively interconnected principal neurons in the hippocampus

Autor: Ivan Galimberti, Flavio Donato, Pico Caroni, Erik Cabuy, Yuichi Deguchi

Publikováno v: Nature Neuroscience. 14:495-504

The extent to which individual neurons are interconnected selectively within brain circuits is an unresolved problem in neuroscience. Neurons can be organized into preferentially interconnected microcircuits, but whether this reflects genetically def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe5b179660f8c8a264acf19b74c7cda
https://doi.org/10.1038/nn.2768

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D1 receptor subtype mediates acute stress-induced dendritic growth of excitatory neurons and gene expression changes associated with stress resilience in the medial prefrontal cortex

Autor: Ryota Shinohara, Akira Sawa, Atsubumi Ogawa, Aliza T. Ehrlich, Masayuki Taniguchi, Yuichi Deguchi, Kentarou Yokogawa, Tomoyuki Furuyashiki, Shiho Kitaoka, Shuh Narumiya

Publikováno v: Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18d066ee23d62b31cfcbf172d2b1fcbd
https://doi.org/10.1254/jpssuppl.wcp2018.0_po1-1-133

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Wnt Signaling Mediates Experience-Related Regulation of Synapse Numbers and Mossy Fiber Connectivities in the Adult Hippocampus

Autor: Ivan Galimberti, Nadine Gogolla, Yuichi Deguchi, Pico Caroni

Publikováno v: Neuron. 62:510-525

Summary We investigated how experience regulates the structure of a defined neuronal circuit in adult mice. Enriched environment (EE) produced a robust and reversible increase in hippocampal stratum lucidum synapse numbers, mossy fiber terminal (LMT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd0cc426898716b402d29aee5418ec9
https://doi.org/10.1016/j.neuron.2009.04.022

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