Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yui Hiraguri"'
Autor:
Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D. Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109247- (2024)
Summary: In normal intestines, a fetal/regenerative/revival cell state can be induced upon inflammation. This plasticity in cell fate is also one of the current topics in human colorectal cancer (CRC). To dissect the underlying mechanisms, we generat
Externí odkaz:
https://doaj.org/article/b7c4b22989424e7d86277299f9e37c54
Autor:
Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-18 (2022)
Abstract Background The emerging concepts of fetal-like reprogramming following tissue injury have been well recognized as an important cue for resolving regenerative mechanisms of intestinal epithelium during inflammation. We previously revealed tha
Externí odkaz:
https://doaj.org/article/0b1ef15512e247f5a2f38806a4814691
Autor:
Ryuichi Okamoto, Hiromichi Shimizu, Kohei Suzuki, Ami Kawamoto, Junichi Takahashi, Mao Kawai, Sayaka Nagata, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Mamoru Watanabe
Publikováno v:
Regenerative Therapy, Vol 13, Iss , Pp 1-6 (2020)
Inflammatory bowel disease (IBD) consists of two major idiopathic gastrointestinal diseases: ulcerative colitis and Crohn's disease. Although a significant advance has been achieved in the treatment of IBD, there remains a particular population of pa
Externí odkaz:
https://doaj.org/article/a19ae1be37fd4ce58f4407ae8f6b0bd4
Autor:
Reiko Kuno, Go Ito, Ami Kawamoto, Yui Hiraguri, Hady Yuki Sugihara, Sayaka Takeoka, Sayaka Nagata, Junichi Takahashi, Mao Tsuchiya, Sho Anzai, Tomohiro Mizutani, Hiromichi Shimizu, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto
Publikováno v:
Biochemistry and Biophysics Reports, Vol 25, Iss , Pp 100906- (2021)
Notch signaling is activated in the intestinal epithelial cells (IECs) of patients with inflammatory bowel disease (IBD), and contributes to mucosal regeneration. Our previous study indicated that TNF-α and Notch signaling may synergistically promot
Externí odkaz:
https://doaj.org/article/0a375b89ba1e4c71a4f4c238859107d9
Autor:
Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui
Publikováno v:
Journal of Gastroenterology. 58:379-393
Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis
Autor:
Akiko Tamura, Go Ito, Hiroki Matsuda, Yoichi Nibe-Shirakihara, Yuichi Hiraoka, Sayuki Kitagawa, Yui Hiraguri, Sayaka Nagata, Emi Aonuma, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima
Publikováno v:
Biochemical and Biophysical Research Communications. 628:147-154
Expression of mucin MUC2, a component of the colonic mucus layer, plays a crucial role in intestinal homeostasis. Here, we describe a new regulator of MUC2 expression, the deubiquitinase ZRANB1 (Trabid). A ZRANB1 mutation changing cysteine to serine
Autor:
Minami Hama, Sho Anzai, Junichi Takahashi, Hady Yuki Sugihara, Shigeru Oshima, Tomohiro Mizutani, M. Tsuchiya, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Mamoru Watanabe, Yui Hiraguri, Kiichiro Tsuchiya, Sayaka Takeoka, Ryuichi Okamoto, Shiro Yui, Reiko Kuno, Ami Kawamoto, Kohei Suzuki
Publikováno v:
Biochemical and Biophysical Research Communications. 542:40-47
Inflammatory bowel disease (IBD) comprises two major subtypes, ulcerative colitis (UC) and Crohn's disease, which are multifactorial diseases that may develop due to genetic susceptibility, dysbiosis, or environmental factors. Environmental triggers
Autor:
Junichi Takahashi, Tomohiro Mizutani, Hady Yuki Sugihara, Sayaka Nagata, Shu Kato, Yui Hiraguri, Sayaka Takeoka, Mao Tsuchiya, Reiko Kuno, Sei Kakinuma, Mamoru Watanabe, Ryuichi Okamoto
Publikováno v:
Cell reports methods. 2(11)
Human intestinal organoids (HIOs) derived from human pluripotent stem cells (hPSCs) hold great promise for translational medical applications. A common method to obtain HIOs has been to harvest floating hindgut spheroids arising from hPSCs. As this t
Autor:
Shiro Yui, Hiromichi Shimizu, Ami Kawamoto, Satoshi Watanabe, Mamoru Watanabe, Sayaka Nagata, Hady Yuki Sugihara, Junichi Takahashi, Shigeru Oshima, Sakurako Kobayashi, Yui Hiraguri, Sayaka Takeoka, Sho Anzai, Ryuichi Okamoto, Reiko Kuno, Kohei Suzuki, Mao Kawai
Publikováno v:
Biochemical and Biophysical Research Communications. 524:533-541
The early-phase wound repair response of the intestinal epithelium is characterized by rapid and organized cell migration. This response is regulated by several humoral factors, including TGF-β. However, due to a lack of appropriate models, the prec
Autor:
Hady Yuki Sugihara, Sayaka Nagata, Junichi Takahashi, Yui Hiraguri, Hiromichi Shimizu, Ryuichi Okamoto, Mamoru Watanabe, Sayaka Takeoka, Shiro Yui, Mao Kawai, Kohei Suzuki, Ami Kawamoto
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 13, Iss, Pp 1-6 (2020)
Regenerative Therapy, Vol 13, Iss, Pp 1-6 (2020)
Inflammatory bowel disease (IBD) consists of two major idiopathic gastrointestinal diseases: ulcerative colitis and Crohn's disease. Although a significant advance has been achieved in the treatment of IBD, there remains a particular population of pa