Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Yuhsin Kuo"'
Autor:
Karsten Menzel, Yuhsin Kuo, Dapeng Chen, Georgy Hartmann, Ying‐Hong Wang, Carolyn R. Cho, Jacqueline B. McCrea, Kazuhiko Asari
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 6, Pp 1039-1048 (2023)
Abstract Letermovir is approved for use in cytomegalovirus‐seropositive hematopoietic stem cell transplant recipients and is investigated in other transplant settings. Nonlinear pharmacokinetics (PKs) were observed in clinical studies after intrave
Externí odkaz:
https://doaj.org/article/32cc1e5539cc48faa74100d6c7ab7fdf
Autor:
Anthony J. Roecker, Kathy M. Schirripa, H. Marie Loughran, Ling Tong, Tao Liang, Kerry L. Fillgrove, Yuhsin Kuo, Kelly Bleasby, Hannah Collier, Michael D. Altman, Melissa C. Ford, Robert E. Drolet, Mali Cosden, Sarah Jinn, Nathan G. Hatcher, Lihang Yao, Monika Kandebo, Joshua D. Vardigan, Rosemarie B. Flick, Xiaomei Liu, Christina Minnick, Laura A. Price, Marla L. Watt, Wei Lemaire, Christine Burlein, Gregory C. Adam, Lauren A. Austin, Jacob N. Marcus, Sean M. Smith, Mark E. Fraley
Publikováno v:
ACS Medicinal Chemistry Letters. 14:146-155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a75f2713f77a436a3c71e753c7d659
https://doi.org/10.1021/acsmedchemlett.2c00441
https://doi.org/10.1021/acsmedchemlett.2c00441
Autor:
Sauzanne Khalilieh, Tamara D. Cabalu, Yuhsin Kuo, Sasha McClain, Larissa Wenning, Ilias Triantafyllou, Yang Liu, Daniel P. Dreyer, Rosa I. Sanchez, S. Aubrey Stoch, Marian Iwamoto, Ka Lai Yee, Kerry L. Fillgrove
Publikováno v:
The Journal of Clinical Pharmacology. 61:394-405
Doravirine, a novel nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus 1 (HIV-1), is predominantly cleared by cytochrome P450 (CYP) 3A4 and metabolized to an oxidative metabolite (M9). Coadministration wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13cbad346534b7d65b034927b3115c5
https://doi.org/10.1002/jcph.1747
https://doi.org/10.1002/jcph.1747
Autor:
Bennett Ma, Peter J. Manley, Ying Li, Yuhsin Kuo, Karsten Menzel, Roy Eisenhandler, Paul Rearden, Sheri Smith
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 42:319-326
Prediction of metabolic clearance has been a challenge for compounds exhibiting minimal turnover in typical in vitro stability experiments. The aim of the current study is to evaluate the utilization of plated human hepatocytes to predict intrinsic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e9f978584a9c902605600ef71962d7
https://doi.org/10.1007/s13318-016-0336-3
https://doi.org/10.1007/s13318-016-0336-3
Autor:
Michael J. Kelly, Marlene A. Jacobson, Kerry L. Fillgrove, Alexander J. Reif, Ken Arrington, Robert M. Garbaccio, Kevin J. Rodzinak, Cheng Wang, Timothy J. Hartingh, Brian C. Magliaro, Sarah L. Huszar, Yuhsin Kuo, Cuyue Tang, Jason M. Uslaner, Vadim Y. Dudkin, Julie A. O'Brien, Mark E. Layton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1260-1264
Optimization of a benzimidazolone template for potency and physical properties revealed 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as a key template on which to develop a new series of mGlu2 positive allosteric modulators (PAMs). Systematic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8abce83ed7482841fbf9df1f25b2368
https://doi.org/10.1016/j.bmcl.2016.01.021
https://doi.org/10.1016/j.bmcl.2016.01.021
Autor:
Edward C. Sherer, Hannah D. G. F. Lehman, Kerry L. Fillgrove, Robert M. Garbaccio, Jason M. Uslaner, Brian C. Magliaro, Marlene A. Jacobson, Cuyue Tang, Yuhsin Kuo, Rossi Michael A, Michael J. Kelly, Joseph E. Pero, Julie A. O'Brien, Leo A. Joyce, Mark E. Layton, Sarah L. Huszar
Publikováno v:
ACS Medicinal Chemistry Letters. 7:312-317
Investigation of a novel amino-aza-benzimidazolone structural class of positive allosteric modulators (PAMs) of metabotropic glutamate receptor 2 (mGluR2) identified [2.2.2]-bicyclic amine 12 as an intriguing lead structure due to its promising physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8561493c7955f8220ec8a593da69c2ed
https://doi.org/10.1021/acsmedchemlett.5b00459
https://doi.org/10.1021/acsmedchemlett.5b00459
Autor:
Natasa Pajkovic, Randy R. Miller, Amrith Bennet, Laïla Bernard, Raymond Gonzalez, Frédéric Poignant, Yuhsin Kuo
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fff92771cea4b254d3c57cb8f1142ca9
https://doi.org/10.1016/j.dmpk.2020.04.224
https://doi.org/10.1016/j.dmpk.2020.04.224
Autor:
Kerry L. Fillgrove, Rosa I. Sanchez, Tamara D. Cabalu, Yuhsin Kuo, Ka Lai Yee, Larissa Wenning
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7019c45c52cb079f9c9c3a0de8f02480
https://doi.org/10.1016/j.dmpk.2020.04.211
https://doi.org/10.1016/j.dmpk.2020.04.211
Autor:
Rowena V. Cube, Cindy E. Nuss, Thomayant Prueksaritanont, Scott M. Doran, Jim Small, Wei Zeng, Julie Ann Luk, Cynthia Chavez-Eng, William O. Cook, T Laethem, Victor N. Uebele, Susan L. Garson, Thomas S. Reger, Richard L. Kraus, Yuhsin Kuo, Christa Mattern, Wei Fang, Cuyue Tang, John J. Renger, Paul J. Coleman, Kelly Ann S. Schlegel, Adekemi B. Taylor, Yuxing Li, Zhi Qiang Yang, James C. Barrow, Shu Youheng, Jeanine E. Ballard, Matthew D. Troyer, George D. Hartman, Steven V. Fox
Publikováno v:
ACS Medicinal Chemistry Letters. 1:504-509
A novel phenyl acetamide series of short-acting T-type calcium channel antagonists has been identified and evaluated using in vitro and in vivo assays. Heterocycle substitutions of the 4-position of the phenyl acetamides afforded potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58657ea13446ca13430d01628baeb7b3
https://doi.org/10.1021/ml100170e
https://doi.org/10.1021/ml100170e
Autor:
Julie A. O'Brien, George D. Hartman, Brian C. Magliaro, James H. Small, Mark E. Fraley, Sarah L. Huszar, Pete H. Hutson, Marlene A. Jacobson, Kerry L. Fillgrove, Cuyue Tang, Jason M. Uslaner, Robert M. Garbaccio, Edward J. Brnardic, Yuhsin Kuo
Publikováno v:
ACS Medicinal Chemistry Letters. 1:406-410
Novel oxazolobenzimidazoles are described as potent and selective positive allosteric modulators of the metabotropic glutamate receptor 2. The discovery of this class and optimization of its physical and pharmacokinetic properties led to the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935a845b29d203b71ab7864dd1215ed0
https://doi.org/10.1021/ml100115a
https://doi.org/10.1021/ml100115a