Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yuhong, She"'
Autor:
Yuhong She, Susanna Cunningham-Rundles, Elisa de Stanchina, Sandy Cheung, Danthanh Hoang, Hong Lin, Xi Kathy Zhou, Barrie R. Cassileth
Publikováno v:
Experimental Biology and Medicine. 234:342-353
Beta glucans are cell wall constituents of yeast, fungi and bacteria, as well as mushrooms and barley. Glucans are not expressed on mammalian cells and are recognized as pathogen-associated molecular patterns (PAMPS) by pattern recognition receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a379b073f3482ea2fd462f00008c4325
https://doi.org/10.3181/0807-rm-226
https://doi.org/10.3181/0807-rm-226
Autor:
Laura Llauger, Julia Aguirre, Nian Wu, Gabriela Chiosis, Joungnam Kim, Huazhong He, R.M. Immormino, Danuta Zatorska, Daniel T. Gewirth, Yuhong She
Publikováno v:
Journal of Medicinal Chemistry. 49:381-390
Hsp90 is a chaperone protein that allows cancer cells to tolerate the many components of dysregulated pathways. Its inactivation may result in targeting multiple molecular alterations and, thus, in reverting the transformed phenotype. The PU-class, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932f12110b7887f26efc72261834d560
https://doi.org/10.1021/jm0508078
https://doi.org/10.1021/jm0508078
Autor:
Frank M. Sirotnak, Neal Rosen, Jose Lobo, Howard I. Scher, Mark G. Kris, Yuhong She, David B. Solit
Publikováno v:
Clinical Cancer Research. 11:1983-1989
Purpose: Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. Continuous inhibition of EGFR signaling is thought necessary for optimal inhibition of tumor cell proliferation. We hypothesized that continuous gefiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a7e0f042dd206d3d7fdb26b921bd2d
https://doi.org/10.1158/1078-0432.ccr-04-1347
https://doi.org/10.1158/1078-0432.ccr-04-1347
Autor:
Mona D, Lee, Yuhong, She, Michael J, Soskis, Christopher P, Borella, Jeffrey R, Gardner, Paula A, Hayes, Benzon M, Dy, Mark L, Heaney, Mark R, Philips, William G, Bornmann, Francis M, Sirotnak, David A, Scheinberg
Publikováno v:
Journal of Clinical Investigation. 114:1107-1116
Peptide deformylase activity was thought to be limited to ribosomal protein synthesis in prokaryotes, where new peptides are initiated with an N-formylated methionine. We describe here a new human peptide deformylase (Homo sapiens PDF, or HsPDF) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77c76b43dcec8b14a141daef1b99dba
https://doi.org/10.1172/jci200422269
https://doi.org/10.1172/jci200422269
Publikováno v:
Molecular Carcinogenesis. 41:150-163
Three unique variants of the CWR22 human prostate cancer xenograft model (CWR22LD1, LD2, and LD3) with a decrease in dependence on androgens were selected under noncastrate conditions, i.e., by outgrowth after transplantation into male NCR (AT) nu mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa8e2b7249db47f817ece67e95fb76b
https://doi.org/10.1002/mc.20051
https://doi.org/10.1002/mc.20051
Autor:
Owen A. O'Connor, Andrew D. Zelenetz, Eunice S. Wang, Frank Sirotnak, Malcolm A.S. Moore, Yuhong She
Publikováno v:
Leukemia & Lymphoma. 44:1027-1035
PDX (10-propargyl-10-deazaaminopterin) is a novel anti-folate with improved membrane transport and polyglutamylation in tumor cells. In prior studies, PDX exhibited enhanced efficacy over methotrexate (MTX) in lung and breast carcinoma xenografts. Be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55b557ac2d576139cd3dd8dd22d4d5c
https://doi.org/10.1080/1042819031000077124
https://doi.org/10.1080/1042819031000077124
Autor:
Xuejun Jiang, Gabriela Chiosis, Cristina C. Clement, Yanlong Kang, Anna Rodina, Jeffrey L. Brodsky, Nian Wu, Joan Massagué, Peter Wipf, Maria Vilenchik, Yuhong She, Kamalika Moulick, Geoffrey W. Krystal, Anne C. Chiang, Joungnam Kim, Sara J. Felts, Julia Aguirre, Julie Litz
Publikováno v:
Nature chemical biology. 3(8)
The heat shock protein 90 (Hsp90) has a critical role in malignant transformation. Whereas its ability to maintain the functional conformations of mutant and aberrant oncoproteins is established, a transformation-specific regulation of the antiapopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588c877fec838540e54cf9bc2beb4374
https://pubmed.ncbi.nlm.nih.gov/17637775
https://pubmed.ncbi.nlm.nih.gov/17637775
Autor:
Jose Lobo, William R. Sellers, Gad Getz, David B. Solit, Neal Rosen, Qing Ye, Iman Osman, Ayana Sawai, Christine A. Pratilas, Judith Sebolt-Leopold, Todd R. Golub, Andrea D. Basso, Levi A. Garraway, Yuhong She
The kinase pathway comprising RAS, RAF, mitogen-activated protein kinase kinase (MEK) and extracellular signal regulated kinase (ERK) is activated in most human tumours, often through gain-of-function mutations of RAS and RAF family members. Using sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ef6e066dccd7c0a2562f5c9027cfb4
https://europepmc.org/articles/PMC3306236/
https://europepmc.org/articles/PMC3306236/
Autor:
Christoph, Jung, Monica, Motwani, Jeremy, Kortmansky, Francis M, Sirotnak, Yuhong, She, Mithat, Gonen, Adriana, Haimovitz-Friedman, Gary K, Schwartz
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(16 Pt 1)
Flavopiridol is a cyclin-dependent kinase inhibitor currently under development by the National Cancer Institute both as a single agent and in combination with chemotherapy. There have been numerous reports that flavopiridol potently enhances the ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abce39dfc2b29c69120735fdc4744c2f
https://pubmed.ncbi.nlm.nih.gov/14676132
https://pubmed.ncbi.nlm.nih.gov/14676132
Autor:
Yuhong, She, Fei, Lee, Jing, Chen, Adriana, Haimovitz-Friedman, Vincent A, Miller, Valerie R, Rusch, Mark G, Kris, F M, Sirotnak
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(10 Pt 1)
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) markedly potentiates the efficacy of many cytotoxic agents against several human cancer xenografts, irrespective of tumor EGFR expression levels. We subsequently investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::605b9ffacdd7261dbdbb8160fc48e70d
https://pubmed.ncbi.nlm.nih.gov/14506170
https://pubmed.ncbi.nlm.nih.gov/14506170