Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Yuhki Yokoyama"'
Autor:
Yuhki Yokoyama, Kazuki Kanayama, Kento Iida, Masako Onishi, Tadasuke Nagatomo, Mayu Ito, Sachiko Nagumo, Kunimitsu Kawahara, Eiichi Morii, Kazuaki Nakane, Hirofumi Yamamoto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Homology is a mathematical tool to quantify "the contact degree", which can be expressed in terms of Betti numbers. The Betti numbers used in this study consisted of two numbers, b0 (a zero-dimensional Betti number) and b1 (a one-dimensional
Externí odkaz:
https://doaj.org/article/445c8984003d4240aa4761542462fecc
Autor:
Momoko Ichihara, Hidekazu Takahashi, Naohiro Nishida, Cristina Ivan, Daisuke Okuzaki, Yuhki Yokoyama, Masahisa Ohtsuka, Norikatsu Miyoshi, Mamoru Uemura, Shinji Tanaka, George Adrian Calin, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto
Publikováno v:
Annals of Gastroenterological Surgery, Vol 7, Iss 3, Pp 458-470 (2023)
Abstract Background Studies have shown that cancer stemness and the endoplasmic reticulum (ER) stress response are inversely regulated in colorectal cancer (CRC), but the mechanism has not been fully clarified. Long noncoding RNAs (lncRNAs) play key
Externí odkaz:
https://doaj.org/article/79d8ece42a13455ab04f084fc73ff162
Autor:
Hiroaki Itakura, Tsuyoshi Hata, Daisuke Okuzaki, Koki Takeda, Kenji Iso, Yamin Qian, Yoshihiro Morimoto, Tomohiro Adachi, Haruka Hirose, Yuhki Yokoyama, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Takao Hinoi, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106478- (2023)
Summary: Somatic cell reprogramming using the microRNAs miR-200c, miR-302s, and miR-369s leads to increased expression of cyclin-dependent kinase inhibitors in human colorectal cancer (CRC) cells and suppressed tumor growth. Here, we investigated whe
Externí odkaz:
https://doaj.org/article/9a45a3748f274a3eba11f287c9aa056a
Publikováno v:
Japanese Dental Science Review, Vol 57, Iss , Pp 174-181 (2021)
Wound healing in the oral and maxillofacial region is a complicated and interactive process. Severe mucosal or skeletal muscle injury by trauma or surgery induces worse healing conditions, including delayed wound closure and repair with excessive sca
Externí odkaz:
https://doaj.org/article/6701f485a2914dca8ae1eae083d8bae8
Autor:
Naoto Tsujimura, Takayuki Ogino, Masayuki Hiraki, Taisei Kai, Hiroyuki Yamamoto, Haruka Hirose, Yuhki Yokoyama, Yuki Sekido, Tsuyoshi Hata, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 618 (2023)
The incidence of inflammatory bowel disease (IBD) is increasing worldwide. It is reported that TGF-β/Smad signal pathway is inactivated in patients with Crohn’s disease by overexpression of Smad 7. With expectation of multiple molecular targeting
Externí odkaz:
https://doaj.org/article/b7086f3b7dce4215a60749c7e4094c66
Autor:
Akemi Shishido, Masaaki Miyo, Kazuki Oishi, Natsumi Nishiyama, Meiqiao Wu, Hiroyuki Yamamoto, Shihori Kouda, Xin Wu, Satoshi Shibata, Yuhki Yokoyama, Hirofumi Yamamoto
Publikováno v:
Life, Vol 13, Iss 3, p 615 (2023)
High expression of low-density lipoprotein receptor-related protein 6 (LRP6), a key component of the Wnt/β-catenin signaling pathway, is reported to be associated with malignant potential in some solid tumors including breast cancer and hepatocellul
Externí odkaz:
https://doaj.org/article/3985c2aa75cf4405be731e9b46d840d8
Autor:
Masatoshi Nomura, Yuichiro Miyake, Akira Inoue, Yuhki Yokoyama, Nanaka Noda, Shihori Kouda, Tsuyoshi Hata, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 203 (2023)
This study aimed to analyze circulating tumor cells (CTCs) from patients with colorectal cancer (CRC). We designed a dielectrophoresis-based micropore system and tested its cell capture with HT29 colon cancer cells. Then, blood samples were drawn fro
Externí odkaz:
https://doaj.org/article/17024ce6921d4ced987589337195ea32
Autor:
Tadafumi Fukata, Tsunekazu Mizushima, Junichi Nishimura, Daisuke Okuzaki, Xin Wu, Haruka Hirose, Yuhki Yokoyama, Yui Kubota, Kazuya Nagata, Naoto Tsujimura, Akira Inoue, Norikatsu Miyoshi, Naotsugu Haraguchi, Hidekazu Takahashi, Taishi Hata, Chu Matsuda, Hisako Kayama, Kiyoshi Takeda, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 658-671 (2018)
The incidence of inflammatory bowel disease (IBD) is increasing. Nucleic acid-based medicine has potential as a next-generation treatment, but it is rarely successful with IBD. The aim of this study was to establish a microRNA-based therapy in an IBD
Externí odkaz:
https://doaj.org/article/a357d8bcac204df6adfa5d2c188773cb
Autor:
Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog, Rugang Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tum
Externí odkaz:
https://doaj.org/article/d5feab71b5d34b35b80ea5240b6980bc
Autor:
Sergey Karakashev, Hengrui Zhu, Yuhki Yokoyama, Bo Zhao, Nail Fatkhutdinov, Andrew V. Kossenkov, Andrew J. Wilson, Fiona Simpkins, David Speicher, Dineo Khabele, Benjamin G. Bitler, Rugang Zhang
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3398-3405 (2017)
Summary: PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors. Here, we show the synergy of BET bromodomain inhibition with PARP inhibition in BRCA-pr
Externí odkaz:
https://doaj.org/article/8f781436fa4e4979a645ce5bfdc70225