Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Yuhki Saito"'
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112050- (2023)
Summary: We describe a patient haploinsufficient for the neuronal RNA binding protein NOVA1 who developed a behavioral motor hyperactivity disorder, suggesting a role of NOVA1 in postnatal motor inhibition. To investigate Nova1’s action in adult Ga
Externí odkaz:
https://doaj.org/article/1eb49e5d7a4b46a2915023fcaf033c37
Autor:
Yuan Yuan, Shirley Xie, Jennifer C. Darnell, Andrew J. Darnell, Yuhki Saito, Hemali Phatnani, Elisabeth A. Murphy, Chaolin Zhang, Tom Maniatis, Robert B. Darnell
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-19 (2018)
Abstract Background Alternative RNA processing plays an essential role in shaping cell identity and connectivity in the central nervous system. This is believed to involve differential regulation of RNA processing in various cell types. However, in v
Externí odkaz:
https://doaj.org/article/cb685f73162747c5a46387f6f24edeab
Autor:
Hun-Way Hwang, Christopher Y. Park, Hani Goodarzi, John J. Fak, Aldo Mele, Michael J. Moore, Yuhki Saito, Robert B. Darnell
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 423-435 (2016)
Accurate and precise annotation of 3′ UTRs is critical for understanding how mRNAs are regulated by microRNAs (miRNAs) and RNA-binding proteins (RBPs). Here, we describe a method, poly(A) binding protein-mediated mRNA 3′ end retrieval by crosslin
Externí odkaz:
https://doaj.org/article/66d95c501fab4a868808f7ec2fad7949
Autor:
Yuhki Saito, Soledad Miranda-Rottmann, Matteo Ruggiu, Christopher Y Park, John J Fak, Ru Zhong, Jeremy S Duncan, Brian A Fabella, Harald J Junge, Zhe Chen, Roberto Araya, Bernd Fritzsch, A J Hudspeth, Robert B Darnell
Publikováno v:
eLife, Vol 5 (2016)
The neuron specific RNA-binding proteins NOVA1 and NOVA2 are highly homologous alternative splicing regulators. NOVA proteins regulate at least 700 alternative splicing events in vivo, yet relatively little is known about the biologic consequences of
Externí odkaz:
https://doaj.org/article/53a008d0115a4c659aae01c373fb5e9f
Autor:
Janelle C Leggere, Yuhki Saito, Robert B Darnell, Marc Tessier-Lavigne, Harald J Junge, Zhe Chen
Publikováno v:
eLife, Vol 5 (2016)
RNA-binding proteins (RBPs) control multiple aspects of post-transcriptional gene regulation and function during various biological processes in the nervous system. To further reveal the functional significance of RBPs during neural development, we c
Externí odkaz:
https://doaj.org/article/1672d5b911334145abbe91cbcee807b2
Autor:
Yi Piao, Ayano Kimura, Satomi Urano, Yuhki Saito, Hidenori Taru, Tohru Yamamoto, Saori Hata, Toshiharu Suzuki
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62431 (2013)
BackgroundAlcadein proteins (Alcs; Alcα, Alcβand Alcγ) are predominantly expressed in neurons, as is Alzheimer's β-amyloid (Aβ) precursor protein (APP). Both Alcs and APP are cleaved by primary α- or β-secretase to generate membrane-associated
Externí odkaz:
https://doaj.org/article/d837907de24f4ed784ec9c3f5f58eae3
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43058 (2012)
Various membrane proteins are shed by proteinases, constitutively and/or when stimulated by external signals. While the physiological significance of external signal-induced cleavages has been intensely investigated, relatively little is known about
Externí odkaz:
https://doaj.org/article/969b21b403a341fc966a4dff79a569c2
Autor:
Yuhki Saito, Mayu Akiyama, Yoichi Araki, Akio Sumioka, Maki Shiono, Hidenori Taru, Tadashi Nakaya, Tohru Yamamoto, Toshiharu Suzuki
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22108 (2011)
BACKGROUND: Amyloid β (Aβ), a causative peptide of Alzheimer's disease, is generated by intracellular metabolism of amyloid β-protein precursor (APP). In general, mature APP (mAPP, N- and O-glycosylated form) is subject to successive cleavages by
Externí odkaz:
https://doaj.org/article/4df11f7d51a142b28f09b4fef359dc48
Autor:
Yuhki Saito, Yanhong Yang, Misa Saito, Park, Christopher Y., Kosuke Funato, Tabar, Viviane, Darnell, Robert B.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/5/2024, Vol. 121 Issue 10, p1-7, 11p
Autor:
Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C. Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
Publikováno v:
Neurobiology of Aging. 123:63-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::874979664c20ded1c9009ca31d15167f
https://doi.org/10.1016/j.neurobiolaging.2022.12.003
https://doi.org/10.1016/j.neurobiolaging.2022.12.003