Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Yuhji Hisamatsu"'
Autor:
Masunori Matsuzaki, Kaoru Ono, Masafumi Yano, Yuhji Hisamatsu, Yukio Saiki, Takayuki Hisaoka, Takeshi Yamamoto, Taketo Tanigawa, Michihiro Kohno, Tomoko Ohkusa
Publikováno v:
Cardiovascular Research. 44:146-155
Objective: In heart failure, little information is available as to the Ca2+ release function of sarcoplasmic reticulum (SR), which plays a major role in cardiac contractile function. Here, we assessed the rapid kinetics of drug-induced Ca2+ release f
Autor:
Shigeki Kobayashi, Masateru Kohno, Masae Suetsugu, Shinichi Okuda, Michihiro Kohno, Takahiro Tokuhisa, Masahiro Doi, Masunori Matsuzaki, Yuhji Hisamatsu, Tomoko Ohkusa, Masafumi Yano
Publikováno v:
Circulation. 105(11)
Background — In heart failure, protein kinase A-mediated hyperphosphorylation of ryanodine receptors (RyRs) in sarcoplasmic reticulum (SR) causes dissociation of FKBP12.6 from RyRs. This results in an abnormal Ca 2+ leak through RyRs, possibly lead