Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Yuhei Takado"'
Autor:
Kiwamu Matsuoka, Kosei Hirata, Naomi Kokubo, Takamasa Maeda, Kenji Tagai, Hironobu Endo, Keisuke Takahata, Hitoshi Shinotoh, Maiko Ono, Chie Seki, Harutsugu Tatebe, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado
Publikováno v:
NeuroImage: Clinical, Vol 41, Iss , Pp 103560- (2024)
In Alzheimer’s disease (AD), aggregated abnormal proteins induce neuronal dysfunction. Despite the evidence supporting the association between tau proteins and brain atrophy, further studies are needed to explore their link to neuronal dysfunction
Externí odkaz:
https://doaj.org/article/e8deeb2471ab4de6915f76e8acd8bb04
Autor:
Masaki Oya, Kiwamu Matsuoka, Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kenji Tagai, Yasuharu Yamamoto, Hitoshi Shimada, Chie Seki, Takashi Itahashi, Yuta Y. Aoki, Haruhisa Ohta, Ryu-ichiro Hashimoto, Genichi Sugihara, Takayuki Obata, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Nobumasa Kato, Yuhei Takado, Hidehiko Takahashi, Makoto Higuchi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Increased excitatory neuronal tones have been implicated in autism, but its mechanism remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppress
Externí odkaz:
https://doaj.org/article/135d6c00a6674ea9842a1e359c92982c
Autor:
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Naoto Watamura, Hiroki Sasaguri, Yuhei Takado, Yoshihiro Yoshihara, Takashi Saito, Takaomi C. Saido
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Accumulating evidence suggests that glutathione loss is closely associated with the progression of neurodegenerative disorders. Here, we found that the neuronal conditional-knockout (KO) of glutamyl-cysteine-ligase catalytic-subunit (GCLC),
Externí odkaz:
https://doaj.org/article/0e2d8155c464445c84a3c0e68311ab35
Autor:
Victor L. Villemagne, Antoine Leuzy, Sandra Sanabria Bohorquez, Santiago Bullich, Hitoshi Shimada, Christopher C. Rowe, Pierrick Bourgeat, Brian Lopresti, Kun Huang, Natasha Krishnadas, Jurgen Fripp, Yuhei Takado, Alexandra Gogola, Davneet Minhas, Robby Weimer, Makoto Higuchi, Andrew Stephens, Oskar Hansson, Vincent Doré, Alzheimer's Disease Neuroimaging Initiative and the AIBL research group
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023)
Abstract INTRODUCTION Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them
Externí odkaz:
https://doaj.org/article/e3a442eac9e64af3bc0f3fc0565a03c8
Autor:
Hikari Nunomura, Taketoshi Kasahara, Taku Hatano, Hitoshi Shimada, Yuhei Takado, Hironobu Endo, Ayako Inoshita, Atsuko Inomata, Toshihisa Murofushi, Shihoko Misawa, Yutaka Machida, Hisamasa Imai
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
We report a 63-year-old female patient with progressive supranuclear palsy (PSP). She presented predominant postural instability and “saccadic ping-pong gaze” (SPPG). She had unprovoked falls recurrently within a year from the onset of gait distu
Externí odkaz:
https://doaj.org/article/776ad5586a56409ca3751183f739c88b
Autor:
Kenji Tagai, Yoko Ikoma, Hironobu Endo, Oiendrila Bhowmik Debnath, Chie Seki, Kiwamu Matsuoka, Hideki Matsumoto, Masaki Oya, Kosei Hirata, Hitoshi Shinotoh, Keisuke Takahata, Shin Kurose, Yasunori Sano, Maiko Ono, Hitoshi Shimada, Kazunori Kawamura, Ming-Rong Zhang, Yuhei Takado, Makoto Higuchi
Publikováno v:
NeuroImage, Vol 264, Iss , Pp 119763- (2022)
Positron emission tomography (PET) with 18F-PM-PBB3 (18F-APN-1607, 18F-Florzolotau) enables high-contrast detection of tau depositions in various neurodegenerative dementias, including Alzheimer's disease (AD) and frontotemporal lobar degeneration (F
Externí odkaz:
https://doaj.org/article/35a5b66d8dcc4f59a4b9f23e33fa7ea0
Autor:
Hideaki Sato, Masako Tsukamoto-Yasui, Yuhei Takado, Noriko Kawasaki, Keiko Matsunaga, Satoko Ueno, Mayuka Kanda, Mai Nishimura, Sachise Karakawa, Muneki Isokawa, Katsuya Suzuki, Kenji Nagao, Makoto Higuchi, Akihiko Kitamura
Publikováno v:
Frontiers in Nutrition, Vol 7 (2020)
Nutritional epidemiology shows that insufficient protein intake is related to senile dementia. The levels of protein intake in aged people are positively associated with memory function, and elderly people with high protein intake have a low risk of
Externí odkaz:
https://doaj.org/article/9bc49d0c27af4a79ac878f951937a713
Autor:
Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Background α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We recently developed a
Externí odkaz:
https://doaj.org/article/ccda0efb0af84ee5ab13c5318aab6d87
Autor:
Manami Takahashi, Takuya Urushihata, Hiroyuki Takuwa, Kazumi Sakata, Yuhei Takado, Eiji Shimizu, Tetsuya Suhara, Makoto Higuchi, Hiroshi Ito
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2018)
Green fluorescence imaging (e.g., flavoprotein autofluorescence imaging, FAI) can be used to measure neuronal activity and oxygen metabolism in living brains without expressing fluorescence proteins. It is useful for understanding the mechanism of va
Externí odkaz:
https://doaj.org/article/609f603f73984bfab7b8e50652c88d68
Autor:
Yuhei Takado, Naoto Sato, Yuta Kanbe, Moyoko Tomiyasu, Lijing Xin, Jamie Near, Kohki Yoshikawa, Naruhiko Sahara, Tatsuya Higashi, Tetsuya Suhara, Makoto Higuchi, Takayuki Obata
Publikováno v:
Nutrients, Vol 11, Iss 7, p 1649 (2019)
Both glutamine (Gln) and glutamate (Glu) are known to exist in plasma and brain. However, despite the assumed relationship between brain and plasma, no studies have clarified the association between them. Proton magnetic resonance spectroscopy (MRS)
Externí odkaz:
https://doaj.org/article/bc564e4df147473e8442f2ce8dd4abf9