Výsledky vyhledávání

DNA modifications that do not cause gene mutations confer the potential for mutagenicity by combined treatment with food chemicals

Autor: Kumiko Ogawa, Aki Kijima, Takashi Umemura, Yuh Yokoo, Shinji Takasu, Yuji Ishii

Publikováno v: Food and Chemical Toxicology. 129:144-152

Cell proliferation plays a key role in fixing mutations induced by DNA damage. We clarified whether this phenomenon occurred after combined treatment with chemicals in food. The effects of antibiotic flumequine (FL), a residue of veterinary medicinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d09aaacccdccabd3040824f40071a03
https://doi.org/10.1016/j.fct.2019.04.011

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Molecular Pathological Differences in Global Gene Expression between Two Sustained Proliferative Lesions, Nodular Regenerative Hepatocellular Hyperplasia and Hepatocellular Adenoma, in Mice

Autor: Aki Kijima, Kumiko Ogawa, Shinji Takasu, Yuh Yokoo, Yuji Ishii, Takashi Umemura

Publikováno v: Toxicologic Pathology. 47:44-52

Long-term exposure to piperonyl butoxide (PBO) induces multiple nodular masses along with hepatocellular tumors in the liver of mice. The histopathological features of the nodules led to our diagnosis of nodular regenerative hepatocellular hyperplasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0f0f58b6debc6af9d9354e43663dd3
https://doi.org/10.1177/0192623318810200

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Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin

Autor: Akiyoshi Nishikawa, Yuji Ishii, Takashi Umemura, Yuh Yokoo, Shinji Takasu, Aki Kijima, Tokuma Yanai, Takuma Tsuchiya

Publikováno v: Journal of Toxicologic Pathology. 31:179-188

Oxidative stress is well known as a key factor of chemical carcinogenesis. However, the actual role of oxidative stress in carcinogenesis, such as oxidative stress-related in vivo mutagenicity, remains unclear. It has been reported that 8-hydroxydeox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41ce8bae15301a186e9990a7c717520b
https://doi.org/10.1293/tox.2018-0024

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Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2-deficient gpt delta mice

Autor: Takashi Umemura, Yuh Yokoo, Takuma Tsuchiya, Shinji Takasu, Yuji Ishii, Aki Kijima, Tokuma Yanai, Akiyoshi Nishikawa

Publikováno v: Journal of Toxicologic Pathology. 31:169-178

Despite its antimicrobial activity, nitrofurantoin (NFT) is a renal carcinogen in rats. Oxidative stress induced by reduction of the nitro group of NFT may contribute to its genotoxicity. This is supported by our recent results indicating that the st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbcb826649334d9770a546dced817d43
https://doi.org/10.1293/tox.2018-0014

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Phosphorylation of protein phosphatase 2A facilitated an early stage of chemical carcinogenesis

Autor: Takehiko Nohmi, Kumiko Ogawa, Aki Kijima, Ken Kuroda, Shinji Takasu, Yuh Yokoo, Takashi Umemura, Yuji Ishii, Kohei Matsushita

Publikováno v: Toxicology and Applied Pharmacology. 336:75-83

Protein phosphatase 2A (PP2A) is a serine-threonine phosphatase that regulates cell signaling pathways. Its inactivation is correlated with tumor malignancy, possibly due to the effects on cell differentiation and malignant cell transformation. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50080a48e084ccd3ca4eea83958c9572
https://doi.org/10.1016/j.taap.2017.10.009

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Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in

Autor: Takuma, Tsuchiya, Aki, Kijima, Yuji, Ishii, Shinji, Takasu, Yuh, Yokoo, Akiyoshi, Nishikawa, Tokuma, Yanai, Takashi, Umemura

Publikováno v: Journal of Toxicologic Pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96818d2cd6c89599b671669b06e3d0a5
https://pubmed.ncbi.nlm.nih.gov/30093786

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Role of p53 in the Progression from Ochratoxin A-Induced DNA Damage to Gene Mutations in the Kidneys of Mice

Autor: Aki Kijima, Tokuma Yanai, Kumiko Ogawa, Daisuke Hibi, Hiroki Sakai, Ken Kuroda, Yukio Kodama, Shinji Takasu, Kenichi Masumura, Takehiko Nohmi, Yuji Ishii, Yuh Yokoo, Kohei Matsushita, Takashi Umemura

Publikováno v: Toxicological Sciences. 144:65-76

Carcinogenic doses of ochratoxin A (OTA) cause increases of mutant frequencies (MFs) of the red/gam gene (Spi(-)) in the kidneys of p53-deficient gpt delta mice, but not in p53-proficient mice. Here, we investigated the role of p53 in the progression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3420fd836e8a74a5fb98bf1e9f1a790
https://doi.org/10.1093/toxsci/kfu267

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In vivo reporter gene mutation and micronucleus assays in gpt delta mice treated with a flame retardant decabromodiphenyl ether

Autor: Takashi Umemura, Shinji Takasu, Kumiko Ogawa, Yuh Yokoo, Takuma Tsuchiya, Yukio Kodama, Yuji Ishii, Aki Kijima

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis.

Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants, have been widely used as additive flame retardants. Recently, the use of brominated flame retardants has been restricted or prohibited under various legislative acts beca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cc652ebfb3f3a7afd1ab9fa451d6b6
https://pubmed.ncbi.nlm.nih.gov/28464995

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