Zobrazeno 1 - 10
of 634
pro vyhledávání: '"Yuh Nung Jan"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract To facilitate our understanding of proteome dynamics during signaling events, robust workflows affording fast time resolution without confounding factors are essential. We present Surface-exposed protein Labeling using PeroxidaSe, H 2 O 2, a
Externí odkaz:
https://doaj.org/article/918b0e5477d746d6b0a6ca04f9904b29
Autor:
Shengjie Feng, Cristina Puchades, Juyeon Ko, Hao Wu, Yifei Chen, Eric E. Figueroa, Shuo Gu, Tina W. Han, Brandon Ho, Tong Cheng, Junrui Li, Brian Shoichet, Yuh Nung Jan, Yifan Cheng, Lily Yeh Jan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA-approved drug niclosamide to inhibit TMEM16F-dependent syncytia
Externí odkaz:
https://doaj.org/article/a4fddbb981434a378a8b8da76a4df0a8
Publikováno v:
eLife, Vol 11 (2022)
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development. Drosophila melanogaster larvae undergo a behavioral transition by
Externí odkaz:
https://doaj.org/article/bb6fa6b9b23b49e18e9b5d2d3d5be7b6
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal so
Externí odkaz:
https://doaj.org/article/e026443ef1f54cb589f59433ef9e4058
Autor:
Shu-Min Chou, Ke-Xin Li, Ming-Yueh Huang, Chao Chen, Yuan-Hung Lin King, Grant Guangnan Li, Wei Zhou, Chin Fen Teo, Yuh Nung Jan, Lily Yeh Jan, Shi-Bing Yang
Publikováno v:
eLife, Vol 10 (2021)
In the postnatal brain, neurogenesis occurs only within a few regions, such as the hippocampal sub-granular zone (SGZ). Postnatal neurogenesis is tightly regulated by factors that balance stem cell renewal with differentiation, and it gives rise to n
Externí odkaz:
https://doaj.org/article/3eaf2011b3be4389b2f1021b0f57db67
Autor:
Mu He, Bing Wu, Wenlei Ye, Daniel D Le, Adriane W Sinclair, Valeria Padovano, Yuzhang Chen, Ke-Xin Li, Rene Sit, Michelle Tan, Michael J Caplan, Norma Neff, Yuh Nung Jan, Spyros Darmanis, Lily Yeh Jan
Publikováno v:
eLife, Vol 9 (2020)
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction
Externí odkaz:
https://doaj.org/article/3a06ea545a1440859b05a65eab370713
Autor:
Ke-Xin Li, Mu He, Wenlei Ye, Jeffrey Simms, Michael Gill, Xuaner Xiang, Yuh Nung Jan, Lily Yeh Jan
Publikováno v:
eLife, Vol 8 (2019)
TMEM16B (ANO2) is the Ca2+-activated chloride channel expressed in multiple brain regions, including the amygdala. Here we report that Ano2 knockout mice exhibit impaired anxiety-related behaviors and context-independent fear memory, thus implicating
Externí odkaz:
https://doaj.org/article/d3acbc4e646f4d7a8b43350142ba315c
Autor:
Shengjie Feng, Shangyu Dang, Tina Wei Han, Wenlei Ye, Peng Jin, Tong Cheng, Junrui Li, Yuh Nung Jan, Lily Yeh Jan, Yifan Cheng
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 567-579.e4 (2019)
Summary: As a Ca2+-activated lipid scramblase and ion channel that mediates Ca2+ influx, TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood coagulation, and bone formation. How a bona fide ion channel scrambles lip
Externí odkaz:
https://doaj.org/article/6686448e492142678c042251216769d5
Publikováno v:
eLife, Vol 8 (2019)
TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as
Externí odkaz:
https://doaj.org/article/46e398b2d1634407bc15e1cffcb0e2be
Autor:
David A. Gorczyca, Susan Younger, Shan Meltzer, Sung Eun Kim, Li Cheng, Wei Song, Hye Young Lee, Lily Yeh Jan, Yuh Nung Jan
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1446-1458 (2014)
A major gap in our understanding of sensation is how a single sensory neuron can differentially respond to a multitude of different stimuli (polymodality), such as propio- or nocisensation. The prevailing hypothesis is that different stimuli are tran
Externí odkaz:
https://doaj.org/article/72503fc52ae841159fcb726e6e3c7108