Výsledky vyhledávání

Cobalt-Catalyzed Z to E Isomerization of Alkenes: An Approach to (E)-β-Substituted Styrenes

Autor: Cai Cheng, Jianhui Chen, Yugui Gu, Man Xu, Yuanzhi Xia, Hongmei Liu

Publikováno v: Organic Letters. 22:1193-1198

An efficient cobalt-catalyzed Z to E isomerization of β-substituted styrenes using the amido-diphosphine ligand was developed, delivering the (E)-isomers with good functional tolerance and high stereoselectivity. The reaction could be scaled up to g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fc09c8f4450dcbc2bb650bcda7b20d5
https://doi.org/10.1021/acs.orglett.0c00072

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Design, synthesis and biological evaluation of novel 2-sulfonylindoles as potential anti-inflammatory therapeutic agents for treatment of acute lung injury

Autor: Xiaona Rong, Zhiguo Liu, Qinqin Xia, Di Wu, Guang Liang, Yugui Gu, Xiaodong Bao, Chuchu Sun, Jianmin Zhou

Publikováno v: European Journal of Medicinal Chemistry. 160:120-132

Acute lung injury (ALI) is primarily driven by inflammation that severely impacts lung function. Novel 2-sulfonylindoles were recently shown to exhibit anti-inflammatory activity through the inhibition of tumor necrosis factor-α (TNF-α) and interle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89540ed79c7bfb17a5bfc8b86e937f82
https://doi.org/10.1016/j.ejmech.2018.10.014

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Piezoelectric and photothermal dual functional film for enhanced dermal wound regeneration via upregulation of Hsp90 and HIF-1α

Autor: Ying An, Qianwen Zhang, Sha Luo, Liwan Song, Chen Yanxin, Junwen Zhang, Mengqi Ye, Yao Yang, Jiang Wu, Anqi Chen, Xiaokun Li, Yugui Gu, Wen Huang, Shengyu Li, Tengxiao Xuan, Yajiao Zhou, Minjie Lin, Huacheng He

Publikováno v: Applied Materials Today. 20:100756

Skin wounds, especially chronic wounds such as pressure and diabetic ulcers, are posing a huge threat to healthcare systems worldwide. Thus, novel strategies to realize effective wound therapy are nowadays extremely needed. Herein, we are the first t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f0ee0f1c24987714aa6c94a365e5def
https://doi.org/10.1016/j.apmt.2020.100756

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Akademický článek

Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives.

Autor: Xiaona Rong, Jingwen Guo, Zheqi Hu, Lehao Huang, Yugui Gu, Yuepiao Cai, Guang Liang, Qinqin Xia

Publikováno v: European Journal of Organic Chemistry; 1/26/2021, Vol. 2021 Issue 4, p701-708, 8p

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Design, Synthesis, and Structure-Activity Relationship Analysis of Thiazolo[3,2-a]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury

Autor: Yugui Gu, Siyang Xiao, Chen Feng, Zhiguo Liu, Chenglong Li, Yiyi Jin, Weitao Fu, Bo Fang, Guang Liang, Yunjie Zhao, Lingfeng Chen

Publikováno v: ChemMedChem. 12(13)

Acute lung injury (ALI) has a high lethality rate, and interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) contribute most to tissue deterioration in cases of ALI. In this study, we designed and synthesized a new series of thiazolo[3,2-a]pyrim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b468caf1d597d5fd27ef672b68dc1c1
https://pubmed.ncbi.nlm.nih.gov/28503918

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