Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection caseResearch in context

Autor: Takeo Kuwata, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Yoko Kawanami, Ryuta Uraki, Kyo Okazaki, Rumi Minami, Yoji Nagasaki, Mami Nagashima, Isao Yoshida, Kenji Sadamasu, Kazuhisa Yoshimura, Mutsumi Ito, Maki Kiso, Seiya Yamayoshi, Masaki Imai, Terumasa Ikeda, Kei Sato, Mako Toyoda, Takamasa Ueno, Takako Inoue, Yasuhito Tanaka, Kanako Tarakado Kimura, Takao Hashiguchi, Yukihiko Sugita, Takeshi Noda, Hiroshi Morioka, Yoshihiro Kawaoka, Shuzo Matsushita, Jumpei Ito, Naoko Misawa, Arnon Plianchaisuk, Ziyi Guo, Alfredo Hina, Jr., Keiya Uriu, Kaoru Usui, Wilaiporn Saikruang, Spyridon Lytras, Ryo Yoshimura, Shusuke Kawakubo, Luca Nishimura, Yusuke Kosugi, Shigeru Fujita, Luo Chen, Jarel Elgin M. Tolentino, Lin Pan, Wenye Li, Maximilian Stanley Yo, Kio Horinaka, Mai Suganami, Adam P. Strange, Mika Chiba, Keiko Iida, Naomi Ohsumi, Kaho Okumura, Shiho Tanaka, Eiko Ogawa, Kyoko Yasuda, Tsuki Fukuda, Rina Osujo, Takasuke Fukuhara, Tomokazu Tamura, Rigel Suzuki, Saori Suzuki, Hayato Ito, Keita Matsuno, Hirofumi Sawa, Naganori Nao, Shinya Tanaka, Masumi Tsuda, Lei Wang, Yoshikata Oda, Zannatul Ferdous, Kenji Shishido, Keita Mizuma, Isshu Kojima, Jingshu Li, Tomoya Tsubo, Shuhei Tsujino, So Nakagawa, Kotaro Shirakawa, Akifumi Takaori-Kondo, Kayoko Nagata, Ryosuke Nomura, Yoshihito Horisawa, Yusuke Tashiro, Yugo Kawai, Kazuo Takayama, Rina Hashimoto, Sayaka Deguchi, Yukio Watanabe, Ayaka Sakamoto, Naoko Yasuhara, Tateki Suzuki, Kanako Kimura, Jiei Sasaki, Yukari Nakajima, Hisano Yajima, Yoshitaka Nakata, Hiroki Futatsusako, Takashi Irie, Ryoko Kawabata, Kaori Tabata, Hesham Nasser, Ryo Shimizu, MST Monira Begum, Michael Jonathan, Yuka Mugita, Otowa Takahashi, Kimiko Ichihara, Chihiro Motozono, Sharee Leong, Akatsuki Saito, Maya Shofa, Yuki Shibatani, Tomoko Nishiuchi, Hiroyuki Asakura, Jiri Zahradnik, Prokopios Andrikopoulos, Miguel Padilla-Blanco, Aditi Konar

Publikováno v: EBioMedicine, Vol 110, Iss , Pp 105439- (2024)

Summary: Background: Emergence of SARS-CoV-2 variants that escape neutralising antibodies hampers the development of vaccines and therapeutic antibodies against SARS-CoV-2. IGHV3-53/3-66-derived public antibodies, which are generally specific to the

Externí odkaz: https://doaj.org/article/e91f95c836a440f4825df3e5b712b6d7

Gliese 12 b: A Temperate Earth-sized Planet at 12 pc Ideal for Atmospheric Transmission Spectroscopy

Autor: Masayuki Kuzuhara, Akihiko Fukui, John H. Livingston, José A. Caballero, Jerome P. de Leon, Teruyuki Hirano, Yui Kasagi, Felipe Murgas, Norio Narita, Masashi Omiya, Jaume Orell-Miquel, Enric Palle, Quentin Changeat, Emma Esparza-Borges, Hiroki Harakawa, Coel Hellier, Yasunori Hori, Kai Ikuta, Hiroyuki Tako Ishikawa, Takanori Kodama, Takayuki Kotani, Tomoyuki Kudo, Juan C. Morales, Mayuko Mori, Evangelos Nagel, Hannu Parviainen, Volker Perdelwitz, Ansgar Reiners, Ignasi Ribas, Jorge Sanz-Forcada, Bun’ei Sato, Andreas Schweitzer, Hugo M. Tabernero, Takuya Takarada, Taichi Uyama, Noriharu Watanabe, Mathias Zechmeister, Néstor Abreu García, Wako Aoki, Charles Beichman, Víctor J. S. Béjar, Timothy D. Brandt, Yéssica Calatayud-Borras, Ilaria Carleo, David Charbonneau, Karen A. Collins, Thayne Currie, John P. Doty, Stefan Dreizler, Gareb Fernández-Rodríguez, Izuru Fukuda, Daniel Galán, Samuel Geraldía-González, Josafat González-Rodríguez, Yuya Hayashi, Christina Hedges, Thomas Henning, Klaus Hodapp, Masahiro Ikoma, Keisuke Isogai, Shane Jacobson, Markus Janson, Jon M. Jenkins, Taiki Kagetani, Eiji Kambe, Yugo Kawai, Kiyoe Kawauchi, Eiichiro Kokubo, Mihoko Konishi, Judith Korth, Vigneshwaran Krishnamurthy, Takashi Kurokawa, Nobuhiko Kusakabe, Jungmi Kwon, Andrés Laza-Ramos, Florence Libotte, Rafael Luque, Alberto Madrigal-Aguado, Yuji Matsumoto, Dimitri Mawet, Michael W. McElwain, Pedro Pablo Meni Gallardo, Giuseppe Morello, Sara Muñoz Torres, Jun Nishikawa, Stevanus K. Nugroho, Masahiro Ogihara, Alberto Peláez-Torres, David Rapetti, Manuel Sánchez-Benavente, Martin Schlecker, Sara Seager, Eugene Serabyn, Takuma Serizawa, Monika Stangret, Aoi Takahashi, Huan-Yu Teng, Motohide Tamura, Yuka Terada, Akitoshi Ueda, Tomonori Usuda, Roland Vanderspek, Sébastien Vievard, David Watanabe, Joshua N. Winn, Maria Rosa Zapatero Osorio

Publikováno v: The Astrophysical Journal Letters, Vol 967, Iss 2, p L21 (2024)

Recent discoveries of Earth-sized planets transiting nearby M dwarfs have made it possible to characterize the atmospheres of terrestrial planets via follow-up spectroscopic observations. However, the number of such planets receiving low insolation i

Externí odkaz: https://doaj.org/article/135ed81aa2bf4c638b0d61cbb2f6cc8b

The Discovery and Follow-up of Four Transiting Short-period Sub-Neptunes Orbiting M Dwarfs

Autor: Yasunori Hori, Akihiko Fukui, Teruyuki Hirano, Norio Narita, Jerome P. de Leon, Hiroyuki Tako Ishikawa, Joel D. Hartman, Giuseppe Morello, Nestor Abreu García, Leticia Álvarez Hernández, Víctor J. S. Béjar, Yéssica Calatayud-Borras, Ilaria Carleo, Gareb Enoc, Emma Esparza-Borges, Izuru Fukuda, Daniel Galán, Samuel Geraldía-González, Yuya Hayashi, Masahiro Ikoma, Kai Ikuta, Keisuke Isogai, Taiki Kagetani, Yugo Kawai, Kiyoe Kawauchi, Tadahiro Kimura, Takanori Kodama, Judith Korth, Nobuhiko Kusakabe, Andrés Laza-Ramos, John H. Livingston, Rafael Luque, Kohei Miyakawa, Mayuko Mori, Felipe Murgas, Jaume Orell-Miquel, Enric Palle, Hannu Parviainen, Alberto Peláez-Torres, Marta Puig-Subirà, Manuel Sánchez-Benavente, Paula Sosa-Guillén, Monika Stangret, Yuka Terada, Sara Muñoz Torres, Noriharu Watanabe, Gaspar Á. Bakos, Khalid Barkaoui, Charles Beichman, Zouhair Benkhaldoun, Andrew W. Boyle, David R. Ciardi, Catherine A. Clark, Karen A. Collins, Kevin I. Collins, Dennis M. Conti, Ian J.M. Crossfield, Mark E. Everett, Elise Furlan, Mourad Ghachoui, Michaël Gillon, Erica J. Gonzales, Jesus Higuera, Keith Horne, Steve B. Howell, Emmanuël Jehin, Kathryn V. Lester, Michael B. Lund, Rachel Matson, Elisabeth C. Matthews, Francisco J. Pozuelos, Boris S. Safonov, Joshua E. Schlieder, Richard P. Schwarz, Ramotholo Sefako, Gregor Srdoc, Ivan A. Strakhov, Mathilde Timmermans, William C. Waalkes, Carl Ziegler, David Charbonneau, Zahra Essack, Natalia M. Guerrero, Hiroki Harakawa, Christina Hedges, Masato Ishizuka, Jon M. Jenkins, Mihoko Konishi, Takayuki Kotani, Tomoyuki Kudo, Takashi Kurokawa, Masayuki Kuzuhara, Jun Nishikawa, Masashi Omiya, George R. Ricker, Sara Seager, Takuma Serizawa, Stephanie Striegel, Motohide Tamura, Akitoshi Ueda, Roland Vanderspek, Sébastien Vievard, Joshua N. Winn

Publikováno v: The Astronomical Journal, Vol 167, Iss 6, p 289 (2024)

Sub-Neptunes with radii of 2–3 R _⊕ are intermediate in size between rocky planets and Neptune-sized planets. The orbital properties and bulk compositions of transiting sub-Neptunes provide clues to the formation and evolution of close-in small p

Externí odkaz: https://doaj.org/article/e90e706d0f7942389d0887e8f3b38aa6

Intratracheal trimerized nanobody cocktail protects against SARS-CoV-2 Omicron in mice

Autor: Kayoko Nagata, Daichi Utsumi, Masamitsu Asaka, Ryota Maeda, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Yohei Yanagida, Yugo Kawai, Kei Sato, Yutaro Yamaoka, Kei Miyakawa, Akihide Ryo, Yasuhiro Yasutomi, Akihiro Imura, Akifumi Takaori-Kondo

SARS-CoV-2 Omicron variants are highly resistant to vaccine-induced immunity and human monoclonal antibodies. Here, we demonstrate that a novel nanobody TP86 potently neutralized both BA.1 and BA.2 Omicron variants, and that the TP17 and TP86 nanobod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d6f37a342ce9a5a1a2c346681a89b96
https://doi.org/10.21203/rs.3.rs-1579128/v1