Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Yufang Deng"'
1
Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor
Autor: Yufang Deng, Claudia V. Perez Almeria, Lieke van Gijzel, Kay Schaller, Line Vedel, David E. Gloriam, Trond Ulven, Hans Bräuner‐Osborne
Publikováno v: Deng, Y, Perez Almeria, C V, van Gijzel, L, Schaller, K, Vedel, L, Gloriam, D E, Ulven, T & Bräuner-Osborne, H 2023, ' Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor ', Basic and Clinical Pharmacology and Toxicology, vol. 132, no. 6, pp. 459-471 . https://doi.org/10.1111/bcpt.13861
The 57-mer full-length GPR15L(25-81) peptide has been identified as the principal endogenous agonist of the G protein-coupled receptor GPR15. Its main activity resides in the C-terminal 11-mer GPR15L(71-81), which has full efficacy but ~40-fold lower
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b91c76ca197ed7b9e619c25171a9b5
https://doi.org/10.1111/bcpt.13861
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2
Delineation of the GPR15 receptor-mediated Gα protein signalling profile in recombinant mammalian cells
Autor: Yufang Deng, Ee Von Moo, Claudia Victoria Pérez Almería, Patrick R. Gentry, Line Vedel, Jesper M. Mathiesen, Hans Bräuner‐Osborne
Publikováno v: Basic and Clinical Pharmacology and Toxicology, 131(2), 104-113. Wiley-Blackwell
Deng, Y, Moo, E V, Pérez Almería, C V, Gentry, P R, Vedel, L, Mathiesen, J M & Bräuner-Osborne, H 2022, ' Delineation of the GPR15 receptor-mediated Gα protein signalling profile in recombinant mammalian cells ', Basic and Clinical Pharmacology and Toxicology, vol. 131, no. 2, pp. 104-113 . https://doi.org/10.1111/bcpt.13738
Deng, Y, Moo, E V, Almería, C V P, Gentry, P R, Vedel, L, Mathiesen, J M & Bräuner-Osborne, H 2022, ' Delineation of the GPR15 receptor-mediated Gα protein signalling profile in recombinant mammalian cells ', Basic and Clinical Pharmacology and Toxicology, vol. 131, no. 2, pp. 104-113 . https://doi.org/10.1111/bcpt.13738
The GPR15 receptor is a G protein-coupled receptor (GPCR), which is activated by an endogenous peptide GPR15L(25–81) and a C-terminal peptide fragment GPR15L(71–81). GPR15 signals through the Gi/o pathway to decrease intracellular cyclic adenosin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34653d98d74e3978578f3737bf61e97b
https://hdl.handle.net/1871.1/123ae551-44fd-47ff-8167-d15bad897b87
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3
Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms
Autor: Yufang Deng, Ee Von Moo, Asuka Inoue, Hans Bräuner‐Osborne
Publikováno v: Deng, Y, Von Moo, E, Inoue, A & Braeuner-Osborne, H 2023, ' Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms ', FEBS Letters, vol. 597, no. 11, pp. 1528-1540 . https://doi.org/10.1002/1873-3468.14622
GPR15 is a G protein-coupled receptor involved in immune disorders such as human immunodeficiency virus-induced enteropathy, multiple sclerosis, and colitis. Yet, the important endocytosis mechanism of GPR15 remained unclear. This study determined th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250e66898784d48118ebe2ec5639e9d0
https://doi.org/10.1002/1873-3468.14622
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4
Transcriptome analysis reveals molecular strategies of Bactrocera dorsalis (Hendel) larvae in response to anoxia
Autor: Yuejin Wang, Liang Liang, Fan Hu, Fan Jiang, Yufang Deng
Publikováno v: Journal of Asia-Pacific Entomology. 24:975-982
Bactrocera dorsalis and its larvae have evolved to cope with the hypoxic environment during their lifetime. In this study, we sequenced the transcriptomes of B. dorsalis under and post anoxia stress. Our data revealed the different biological mechani
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f245fd8686524df8707445cd9a6ae640
https://doi.org/10.1016/j.aspen.2021.09.004
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8
Conceptual design and evaluation of a novel bilateral pretension seatbelt: a computational study
Autor: Feng Zhu, Yufang Deng, Guanjun Zhang, Xianping Du, Libo Cao
Publikováno v: International Journal of Crashworthiness. 25:391-400
The aim of this study is to design a novel, high-efficiency and low-cost Bilateral Pretensioner (BLP) and evaluate it using a computational approach, i.e. coupling of FEA and multibody dynamics. Th...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25ff1c770c782ceb492f35d2881eede8
https://doi.org/10.1080/13588265.2019.1602972
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9
Design, synthesis and biological evaluation of deuterated Vismodegib for improving pharmacokinetic properties
Autor: Fangying, Wang, Hongxia, Jiang, Yufang, Deng, Jiang, Yu, Miao, Zhan, Lifeng, Zhao, Yuanwei, Chen
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:2399-2402
Vismodegib is an oral and high selective hedgehog (Hh) inhibitor used for the treatment of basal cell carcinoma (BCC). In this work, analogs of Vismodegib with deuterium-for-hydrogen replacement at certain metabolically active sites were prepared and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19794513fcb7d2556b51bfb122a549b2
https://doi.org/10.1016/j.bmcl.2018.06.025
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10
Effects of anoxia on survival and gene expression in Bactrocera dorsalis
Autor: Yuejin Wang, Lili Ren, Yufang Deng, Xiwu Gao, Fan Hu
Publikováno v: Journal of Insect Physiology. 107:186-196
The oriental fruit fly (Bactrocera dorsalis) larvae may commonly experience a hypoxia microenvironment and have evolved the ability to survive in the low oxygen condition with some physiological and biochemical mechanisms. However, little is known ab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b1b42071872f5837d6a7be5c808ecf
https://doi.org/10.1016/j.jinsphys.2018.04.004
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