Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Yuen Yi Hon"'
Autor:
Yuen Yi Hon, Jie Wang, Henrietta Abodakpi, Anand Balakrishnan, Michael Pacanowski, Sushanta Chakder, Patroula Smpokou, Kathleen Donohue, Yow‐Ming C. Wang
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2438-2457 (2023)
Abstract This paper summarizes key features of the dose‐finding strategies used in the development of 11 approved new molecular entities that are first‐in‐class enzyme replacement therapy (ERT), with a goal to gain insight into the dose explora
Externí odkaz:
https://doaj.org/article/1de7a515a1ad422dad1cb6819654c91f
Autor:
Elimika Pfuma Fletcher, Martina Sahre, Yuen Yi Hon, Anand Balakrishnan, Lin Zhou, Qin Sun, Jie Wang, Kimberly Maxfield, Raajan Naik, Shiew Mei Huang, Yow-Ming C. Wang
Publikováno v:
The AAPS Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ddefe72406f76bd2b8ef0c3408a036
https://doi.org/10.1208/s12248-023-00819-0
https://doi.org/10.1208/s12248-023-00819-0
Physiologically Based Pharmacokinetic Modeling of Metformin in Children and Adolescents With Obesity
Autor:
Jennifer Lynn Ford, Jacqueline G. Gerhart, Andrea N. Edginton, Jack A. Yanovski, Yuen Yi Hon, Daniel Gonzalez
Publikováno v:
Journal of clinical pharmacology. 62(8)
Childhood obesity continues to rise in the United States and, with it, the off-label use of metformin for weight loss. The influence of age and obesity on the drug's disposition and exposure has not previously been studied using a mechanistic framewo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237a0f391ec4efc631dda54662fa66e9
https://pubmed.ncbi.nlm.nih.gov/35119103
https://pubmed.ncbi.nlm.nih.gov/35119103
Publikováno v:
The AAPS Journal. 18:395-403
Immunogenicity assessment is important for biological products due to potential impacts of immunogenicity on safety and efficacy. We reviewed the prescribing information and the FDA's clinical pharmacology review of 121 approved biological products f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33dd59723cd995f2f0aaa764c11a6ea
https://doi.org/10.1208/s12248-015-9857-y
https://doi.org/10.1208/s12248-015-9857-y
Autor:
Yuen Yi Hon, Dihua Xu, Gregory J. Kato, Caterina P. Minniti, James S. Nichols, Marlene Peters-Lawrence, Anna Conrey, George Grimes, Nitin Malik, Kara Marie H. Delaney, Carly Cantilena, Alexander M. Gorbach, Miles Seidel, Laurel Mendelsohn
Publikováno v:
The Lancet Haematology. 1:e95-e103
Summary Background Well-tolerated and effective treatments are needed for chronic leg ulcers in sickle cell anaemia. Topical sodium nitrite, a known nitric oxide donor, enhances blood flow in ulcers and has known bacteriostatic effects. We aimed to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8317b28415f24955ae29c7a4f17f106
https://doi.org/10.1016/s2352-3026(14)00019-2
https://doi.org/10.1016/s2352-3026(14)00019-2
Autor:
Yuen Yi Hon1 chon@cc.nih.gov, Chamberlain, Christine E.1, Kleiner, David E.2, Ring, Michael S.3, Hale, Douglas A.3, Kirk, Allan D.3, Mannon, Roslyn B.3
Publikováno v:
Clinical Transplantation. Jul/Aug2010, Vol. 24 Issue 4, p557-563. 7p. 4 Charts, 2 Graphs.
Publikováno v:
Journal of Chromatography A. 1271:207-216
The enantioseparation of warfarin (WAR) along with the five positional and optical isomers is challenging because of the difficulty to simultaneously separate and quantitate these chiral compounds. Currently, no effective chiral CE-MS methods exist f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7515b4cb6a838f2ab017a6fe1056bb1f
https://doi.org/10.1016/j.chroma.2012.11.046
https://doi.org/10.1016/j.chroma.2012.11.046
Autor:
Raul M. Alfaro, Orsolya Roza, Jack A. Yanovski, James C. Reynolds, Yuen Yi Hon, Wai Johnn Sam, Karim A. Calis
Steady-state population pharmacokinetics of a noncommercial immediate-release metformin (hydrochloride) drug product were characterized in 28 severely obese children with insulin resistance. The concentration-time profiles with double peaks were well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28824e552b1acc2f4336b3e3f7c37806
https://europepmc.org/articles/PMC5233569/
https://europepmc.org/articles/PMC5233569/
Autor:
He Sun, Angelo M. Taveira-DaSilva, Erik R. Swenson, Yang Yang, Yuen Yi Hon, Xin Tian, Mark T. Gladwin, Roberto F. Machado, Elaina E. Lin
This study investigated the effects of aerobic-to-anaerobic exercise on nitrite stores in the human circulation and evaluated the effects of systemic nitrite infusion on aerobic and anaerobic exercise capacity and hemodynamics. Six healthy volunteers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29916944416dadb8561438f135f1e4b7
https://europepmc.org/articles/PMC4754905/
https://europepmc.org/articles/PMC4754905/
Autor:
Christine E. Chamberlain, Yuen Yi Hon, Allan D. Kirk, Su-Jun Lee, Douglas A. Hale, Joyce A. Goldstein, Roslyn B. Mannon, Wai-Johnn Sam
Publikováno v:
Transplantation. 92:1342-1347
Sirolimus (SRL) absorption and metabolism are affected by p-glycoprotein-mediated transport and CYP3A enzyme activity, which are further under the influences of cytokine concentrations. This retrospective study determined the associations of adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172a85f9f9985a2dad251ff07ef8bf40
https://doi.org/10.1097/tp.0b013e3182384ae2
https://doi.org/10.1097/tp.0b013e3182384ae2