Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Yueming Qian"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3925-3935 (2020)
The hinge region of immunoglobulin G1 (IgG1) is used as a common linker for Fc-fusion therapeutic proteins. With the advances of high-resolution mass spectrometry and sample treatment strategies, unexpected O-linked glycosylation has been observed in
Externí odkaz:
https://doaj.org/article/95f781049f7d4746ad6e3b0abc5a0ef6
Autor:
Qin He, Jianlin Xu, Erik Vandermark, Jun Tian, Yueming Qian, Cynthia Chelius, Jongchan Lee, Michael C. Borys, Zheng Jian Li, Girish Pendse
Publikováno v:
Data in Brief, Vol 39, Iss , Pp 107491- (2021)
In this article, we present four sets of data from high-throughput screening (HTS) studies of different chemically defined media using an industrially relevant Chinese hamster ovary (CHO) cell line. While complex hydrolysate media was used in the ear
Externí odkaz:
https://doaj.org/article/0d07d6fd26134ab696ee55df8a686e52
Autor:
Steven W. Sowa, Yueming Qian, Kathryn L. Aron, Ping Xu, Erik Langsdorf, Bethanne Warrack, Nelly Aranibar, Gabi Tremml, Jianlin Xu, Duncan McVey, Michael Reily, Anurag Khetan, Michael C. Borys, Zheng Jian Li
Publikováno v:
Data in Brief, Vol 33, Iss , Pp 106591- (2020)
In this article, we provide four data sets for an industrial Chinese Hamster Ovary (CHO) cell line producing antibodies during a 14-day bioreactor run. This cell line was selected for further evaluation because of its significant titer loss as the ce
Externí odkaz:
https://doaj.org/article/542fd1b1e063445a8be941eb848a5c5d
Autor:
Zhiqiang Chen, Yueming Qian, Yuanli Song, Xuankuo Xu, Li Tao, Nesredin Mussa, Sanchayita Ghose, Zheng Jian Li
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery. Despite the success of protein engineering in improving antibody bioph
Externí odkaz:
https://doaj.org/article/4681f5b0243b4abfb5f83706253a71ac
Autor:
Chunhua Lan, Yueming Qian, Yumin Wang, Yuemin Chen, Chensheng Lin, Yanding Zhang, Xiaojing Huang
Publikováno v:
Clinical Oral Investigations.
Autor:
Erik Langsdorf, Yueming Qian, Michael D. Reily, Jianlin Xu, Nan-xin Qian, Nelly Aranibar, Zheng Jian Li, Christopher Oliveira, Qin He, Susan Egan, Michael C. Borys, Jun Tian, Bethanne M. Warrack
Publikováno v:
Engineering in Life Sciences
Increasing cell culture productivity of recombinant proteins via process improvements is the primary focus for research groups within biologics manufacturing. Any recommendations to improve a manufacturing process obviously must be effective, but als
Autor:
Yueming Qian, Erik Vandermark, Qin He, Girish Pendse, Jongchan Lee, Cynthia Chelius, Michael C. Borys, Jun Tian, Zheng Jian Li, Jianlin Xu
Publikováno v:
Data in Brief
Data in Brief, Vol 39, Iss, Pp 107491-(2021)
Data in Brief, Vol 39, Iss, Pp 107491-(2021)
In this article, we present four sets of data from high-throughput screening (HTS) studies of different chemically defined media using an industrially relevant Chinese hamster ovary (CHO) cell line. While complex hydrolysate media was used in the ear
Autor:
Zhuangrong Huang, Jianlin Xu, Jun Tian, Kathryn L. Aron, Yueming Qian, Michael C. Borys, Zhengjian Li, Girish Pendse
Publikováno v:
Processes; Volume 10; Issue 3; Pages: 533
The use of antioxidants in Chinese hamster ovary (CHO) cell cultures to improve monoclonal antibody production has been a topic of great interest. Nevertheless, the antioxidants do not have consistent benefits of production improvement, which might b
Autor:
Sanchayita Ghose, Yueming Qian, Li Tao, Nesredin Mussa, Zhiqiang Chen, Zheng Jian Li, Yuanli Song, Xuankuo Xu
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Manufacturability of immunoglobulin G4 (IgG4) antibodies from the Chemistry, Manufacture, and Controls (CMC) perspective has received little attention during early drug discovery. Despite the success of protein engineering in improving antibody bioph
Autor:
Stefan Kirov, Nan-xin Qian, Zhiqiang Chen, Michael C. Borys, Yueming Qian, Xuankuo Xu, Richard Ludwig, Xin Huang, Li Tao, Xuning Wang, Zheng Jian Li, Kandasamy Ravi
Publikováno v:
Biotechnology and Bioengineering. 115:2377-2382
This study reports findings of an unusual cluster of mutations spanning 22 bp (base pairs) in a monoclonal antibody expression vector. It was identified by two orthogonal methods: mass spectrometry on expressed protein and next-generation sequencing